Ingestion of miso regulates immunological robustness in mice.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2022
2022
Historique:
received:
03
08
2021
accepted:
07
12
2021
entrez:
21
1
2022
pubmed:
22
1
2022
medline:
17
2
2022
Statut:
epublish
Résumé
In Japan, there is a long history of consumption of miso, a fermented soybean paste, which possesses beneficial effects on human health. However, the mechanism behind these effects is not fully understood. To clarify the effects of miso on immune cells, we evaluated its immunomodulatory activity in mice. Miso did not alter the percentage of B and T cells in the spleen; however, it increased CD69+ B cells, germinal center B cells and regulatory T cells. Anti-DNA immunoglobulin M antibodies, which prevent autoimmune disease, were increased following ingestion of miso. Transcriptome analysis of mouse spleen cells cultured with miso and its raw material revealed that the expression of genes, including interleukin (IL)-10, IL-22 and CD86, was upregulated. Furthermore, intravital imaging of the small intestinal epithelium using a calcium biosensor mouse line indicated that miso induced Ca2+ signaling in a manner similar to that of probiotics. Thus, ingestion of miso strengthened the immune response and tolerance in mice. These results appear to account, at least in part, to the salubrious effects of miso.
Identifiants
pubmed: 35061718
doi: 10.1371/journal.pone.0261680
pii: PONE-D-21-23058
pmc: PMC8782471
doi:
Substances chimiques
Antigens, CD
0
Antigens, Differentiation, T-Lymphocyte
0
B7-2 Antigen
0
CD69 antigen
0
Cd86 protein, mouse
0
IL10 protein, mouse
0
Interleukins
0
Lectins, C-Type
0
Interleukin-10
130068-27-8
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0261680Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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