Gammaherpesvirus Alters Alveolar Macrophages According to the Host Genetic Background and Promotes Beneficial Inflammatory Control over Pneumovirus Infection.
Animals
CD8-Positive T-Lymphocytes
/ immunology
Cytokines
/ metabolism
Female
Genetic Background
Herpesviridae Infections
/ genetics
Immunity, Innate
Inflammation
/ immunology
Lung
/ immunology
Macrophages, Alveolar
/ immunology
Male
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Monocytes
/ immunology
Pneumococcal Infections
/ immunology
Pneumovirus
/ immunology
Pneumovirus Infections
/ genetics
Rhadinovirus
/ immunology
alveolar macrophages
animal models
gammaherpesvirus
immunopathogenesis
inflammation
innate and adaptive immunity
pneumoviridae
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
06 01 2022
06 01 2022
Historique:
received:
06
12
2021
revised:
03
01
2022
accepted:
04
01
2022
entrez:
22
1
2022
pubmed:
23
1
2022
medline:
22
2
2022
Statut:
epublish
Résumé
Human respiratory syncytial virus (hRSV) infection brings a wide spectrum of clinical outcomes, from a mild cold to severe bronchiolitis or even acute interstitial pneumonia. Among the known factors influencing this clinical diversity, genetic background has often been mentioned. In parallel, recent evidence has also pointed out that an early infectious experience affects heterologous infections severity. Here, we analyzed the importance of these two host-related factors in shaping the immune response in pneumoviral disease. We show that a prior gammaherpesvirus infection improves, in a genetic background-dependent manner, the immune system response against a subsequent lethal dose of pneumovirus primary infection notably by inducing a systematic expansion of the CD8
Identifiants
pubmed: 35062301
pii: v14010098
doi: 10.3390/v14010098
pmc: PMC8777918
pii:
doi:
Substances chimiques
Cytokines
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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