Effect of Photodynamic Therapy on Halitosis: A Systematic Review of Randomized Controlled Trials.
halitosis
laser
photodynamic therapy
systematic review
Journal
Sensors (Basel, Switzerland)
ISSN: 1424-8220
Titre abrégé: Sensors (Basel)
Pays: Switzerland
ID NLM: 101204366
Informations de publication
Date de publication:
08 Jan 2022
08 Jan 2022
Historique:
received:
11
12
2021
revised:
03
01
2022
accepted:
06
01
2022
entrez:
22
1
2022
pubmed:
23
1
2022
medline:
27
1
2022
Statut:
epublish
Résumé
This systematic review aimed to assess the effectiveness and safety of aPDT for the treatment of halitosis. Search strategies were conducted in October 2021 without language or data restrictions, on the following databases: MEDLINE, EMBASE, CENTRAL, LILACS and BBO, as well as a manual search. Randomized clinical trials (RCTs) with parallel design were considered for inclusion, assessing individuals (adolescents and adults) with a clinical diagnosis of halitosis treated with photodynamic therapy (aPDT). Primary outcomes assessed were halitosis measurements, adverse events and quality of life. The risk of bias for each included study was evaluated with the Cochrane Risk of Bias tool and the certainty of the body of the evidence was assessed with the GRADe approach. Six RCTs (total of 225 participants) were included and due to clinical diversities it was not possible to group the outcome data in meta-analyses. Based on very low-certainty evidence (GRADE) the results showed that, when compared to tongue scraper, aPDT seems to promote a little to no difference in reducing halitosis and in the microbiological analysis. No adverse events were reported. Considering aPDT combined with tongue scraper, better outcome results were observed when compared to tongue scraper alone. Based on very low-certainty evidence, the findings of this review are uncertain about the effects of aPDT for halitosis control. Further RCTs with higher number of participants and long term assessments need to be conducted to support the use of this intervention. The protocol was registered in the PROSPERO database (number: CRD42020215319) on 19 November 2020-retrospectively registered.
Sections du résumé
BACKGROUND
BACKGROUND
This systematic review aimed to assess the effectiveness and safety of aPDT for the treatment of halitosis.
METHODS
METHODS
Search strategies were conducted in October 2021 without language or data restrictions, on the following databases: MEDLINE, EMBASE, CENTRAL, LILACS and BBO, as well as a manual search. Randomized clinical trials (RCTs) with parallel design were considered for inclusion, assessing individuals (adolescents and adults) with a clinical diagnosis of halitosis treated with photodynamic therapy (aPDT). Primary outcomes assessed were halitosis measurements, adverse events and quality of life. The risk of bias for each included study was evaluated with the Cochrane Risk of Bias tool and the certainty of the body of the evidence was assessed with the GRADe approach.
RESULTS
RESULTS
Six RCTs (total of 225 participants) were included and due to clinical diversities it was not possible to group the outcome data in meta-analyses. Based on very low-certainty evidence (GRADE) the results showed that, when compared to tongue scraper, aPDT seems to promote a little to no difference in reducing halitosis and in the microbiological analysis. No adverse events were reported. Considering aPDT combined with tongue scraper, better outcome results were observed when compared to tongue scraper alone.
CONCLUSIONS
CONCLUSIONS
Based on very low-certainty evidence, the findings of this review are uncertain about the effects of aPDT for halitosis control. Further RCTs with higher number of participants and long term assessments need to be conducted to support the use of this intervention. The protocol was registered in the PROSPERO database (number: CRD42020215319) on 19 November 2020-retrospectively registered.
Identifiants
pubmed: 35062433
pii: s22020469
doi: 10.3390/s22020469
pmc: PMC8780921
pii:
doi:
Types de publication
Journal Article
Review
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : São Paulo Research Foundation (FAPESP)
ID : 2019/14229-6
Organisme : Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
ID : 306577/2020-8
Organisme : Coordenação de Aperfeicoamento de Pessoal de Nível Superior (CAPES)
ID : 88887.646066/2021-00
Références
J Appl Oral Sci. 2011 Apr;19(2):90-4
pubmed: 21552707
J Breath Res. 2008 Mar;2(1):017010
pubmed: 21386154
Ann Stomatol (Roma). 2015 Jul 28;6(2):35-42
pubmed: 26330902
Photodiagnosis Photodyn Ther. 2021 Mar;33:102057
pubmed: 33238198
Medicine (Baltimore). 2019 Jan;98(1):e13939
pubmed: 30608426
Photodiagnosis Photodyn Ther. 2020 Dec;32:102059
pubmed: 33065302
Lasers Med Sci. 2016 Jan;31(1):41-7
pubmed: 26510574
BMC Oral Health. 2019 Mar 13;19(1):45
pubmed: 30866896
Trials. 2014 Nov 14;15:443
pubmed: 25394474
Phys Ther. 2009 Sep;89(9):873-80
pubmed: 19723669
J Antimicrob Chemother. 2006 Jun;57(6):1227-30
pubmed: 16549510
Photodiagnosis Photodyn Ther. 2020 Dec;32:102006
pubmed: 32950729
Lasers Med Sci. 2020 Feb;35(1):233-293
pubmed: 31845040
J Am Dent Assoc. 1957 Jul;55(1):37-46
pubmed: 13438639
Lasers Med Sci. 2022 Mar;37(2):877-886
pubmed: 33987732
J Periodontal Res. 2008 Apr;43(2):186-93
pubmed: 18302621
BMJ. 2008 Apr 26;336(7650):924-6
pubmed: 18436948
BMJ. 2021 Mar 29;372:n71
pubmed: 33782057
Clinics (Sao Paulo). 2020 Sep 11;75:e1764
pubmed: 32935823
Quintessence Int. 2017;48(7):575-583
pubmed: 28512650
Photodiagnosis Photodyn Ther. 2021 Mar;33:102128
pubmed: 33276115
Life Sci. 2006 Jul 10;79(7):660-4
pubmed: 16564550
Evid Based Nurs. 2001 Oct;4(4):100-4
pubmed: 11762092
Int J Paediatr Dent. 2006 Nov;16(6):399-404
pubmed: 17014537
Mol Oral Microbiol. 2019 Jun;34(3):85-96
pubmed: 30927516
J Clin Periodontol. 2009 Nov;36(11):970-5
pubmed: 19811581
Medicine (Baltimore). 2019 Sep;98(39):e16976
pubmed: 31574796
Int Dent J. 2008 Jun;58(3):151-8
pubmed: 18630111
Medicine (Baltimore). 2019 Jul;98(27):e16275
pubmed: 31277154
J Biophotonics. 2016 Dec;9(11-12):1337-1343
pubmed: 27248838
Rev Lat Am Enfermagem. 2006 Sep-Oct;14(5):821-3
pubmed: 17117270
Ther Adv Drug Saf. 2019 Sep 23;10:2042098619854881
pubmed: 31579502
J Dent Hyg. 2010 Spring;84(2):65-74
pubmed: 20359417
Syst Rev. 2016 Dec 5;5(1):210
pubmed: 27919275
BMJ. 2006 Sep 23;333(7569):632-5
pubmed: 16990322
J Dent Res. 2001 May;80(5):1441-4
pubmed: 11437216
Open Dent J. 2018 Apr 30;12:322-330
pubmed: 29760825
Photodiagnosis Photodyn Ther. 2020 Dec;32:102019
pubmed: 32950726
Cochrane Database Syst Rev. 2019 Dec 11;12:CD012213
pubmed: 31825092