Improving the kinetic parameters of nicotine oxidizing enzymes by homologous structure comparison and rational design.

Bacterial Proteins / chemistry Kinetics Nicotine / metabolism Oxidation-Reduction Pseudomonas
3D structure 6-Hydroxynicotine Flavin Flavoprotein Nicotine Nicotine binding Nicotine oxidase Protein engineering

Journal

Archives of biochemistry and biophysics
ISSN: 1096-0384
Titre abrégé: Arch Biochem Biophys
Pays: United States
ID NLM: 0372430

Informations de publication

Date de publication:
30 03 2022
Historique:
received: 08 09 2021
revised: 17 12 2021
accepted: 14 01 2022
pubmed: 23 1 2022
medline: 4 5 2022
entrez: 22 1 2022
Statut: ppublish

Résumé

Demand exists for a nicotine oxidase enzyme with high catalytic efficiency for a variety of applications including the in vivo detection of nicotine, therapeutic enzymatic blockade of nicotine from the CNS, and inactivation of toxic industrial wastes generated in the manufacture of tobacco products. Nicotine oxidase enzymes identified to date suffer from low efficiency, exhibiting either a high k

Identifiants

DOI: 10.1016/j.abb.2022.109122 PMID: 35063417
pubmed: 35063417
pii: S0003-9861(22)00007-8
doi: 10.1016/j.abb.2022.109122
pii:
doi:

Substances chimiques

Bacterial Proteins 0
Nicotine 6M3C89ZY6R

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

109122

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

Auteurs

Dwight O Deay (DO)

Department of Molecular Biosciences, University of Kansas, Lawrence, KS, 66045, USA.

Steve Seibold (S)

Department of Molecular Biosciences, University of Kansas, Lawrence, KS, 66045, USA.

Kevin P Battaile (KP)

NYX, New York Structural Biology Center, Upton, NY, 11973, USA.

Scott Lovell (S)

Protein Structure Laboratory, University of Kansas, Lawrence, KS, 66044, USA.

Mark L Richter (ML)

Department of Molecular Biosciences, University of Kansas, Lawrence, KS, 66045, USA.

Peter A Petillo (PA)

Design-Zyme LLC, Lawrence, KS, 66045, USA. Electronic address: alchmist@design-zyme.com.

Articles similaires

Atomic view of photosynthetic metabolite permeability pathways and confinement in synthetic carboxysome shells.

Daipayan Sarkar, Christopher Maffeo, Markus Sutter et al.
1.00
Photosynthesis Ribulose-Bisphosphate Carboxylase Carbon Dioxide Molecular Dynamics Simulation Cyanobacteria

A molecular mechanism for bright color variation in parrots.

Roberto Arbore, Soraia Barbosa, Jindich Brejcha et al.
1.00
Animals Feathers Pigmentation Parrots Aldehyde Dehydrogenase

Two codependent routes lead to high-level MRSA.

Abimbola Feyisara Adedeji-Olulana, Katarzyna Wacnik, Lucia Lafage et al.
1.00
Methicillin-Resistant Staphylococcus aureus Penicillin-Binding Proteins Peptidoglycan Bacterial Proteins Anti-Bacterial Agents

Tumor-targeted glutathione oxidation catalysis with ruthenium nanoreactors against hypoxic osteosarcoma.

Hanchen Zhang, Nicolás Montesdeoca, Dongsheng Tang et al.
1.00
Osteosarcoma Animals Glutathione Oxidation-Reduction Mice

Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes › Improving the kinetic parameters of nicotine...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Cinétique › Improving the kinetic parameters of nicotine...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyridines › Nicotine › Improving the kinetic parameters of nicotine...
questionsmedicales.fr › Métabolisme › Métabolisme énergétique › Oxydoréduction › Improving the kinetic parameters of nicotine...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Pseudomonadaceae › Pseudomonas › Improving the kinetic parameters of nicotine...