Potential interactions among myricetin and dietary flavonols through the inhibition of human UDP-glucuronosyltransferase in vitro.

Flavonoids Flavonols Glucuronosyltransferase / metabolism Humans Microsomes, Liver Uridine Diphosphate / metabolism
Enzyme inhibition Flavonols Food–drug interactions In Silico docking Myricetin UGTs

Journal

Toxicology letters
ISSN: 1879-3169
Titre abrégé: Toxicol Lett
Pays: Netherlands
ID NLM: 7709027

Informations de publication

Date de publication:
01 Apr 2022
Historique:
received: 14 07 2021
revised: 04 01 2022
accepted: 17 01 2022
pubmed: 23 1 2022
medline: 4 5 2022
entrez: 22 1 2022
Statut: ppublish

Résumé

Myricetin is a dietary flavonol and possesses multiple bioactivities, which making it an excellent nutritional supplement and a new drug candidate. However, whether myricetin and other homologous dietary flavonols affect the activities of UDP-glucuronosyltransferases (UGT) enzymes and facilitated food-drug interactions remains unclear. Our results demonstrated that myricetin displayed broad-spectrum inhibition against human UGTs. Myricetin exhibited strong inhibitory effects against UGT1A1, 1A3, 1A6, 1A7, 1A10 (IC

Identifiants

DOI: 10.1016/j.toxlet.2022.01.007 PMID: 35063619
pubmed: 35063619
pii: S0378-4274(22)00018-2
doi: 10.1016/j.toxlet.2022.01.007
pii:
doi:

Substances chimiques

Flavonoids 0
Flavonols 0
Uridine Diphosphate 58-98-0
myricetin 76XC01FTOJ
Glucuronosyltransferase EC 2.4.1.17

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

40-47

Informations de copyright

Copyright © 2022 Elsevier B.V. All rights reserved.

Auteurs

Xichuan Li (X)

Tianjin Key Laboratory of Animal and Plant Resistance, College of Life Sciences, Tianjin Normal University, Tianjin, 300387, PR China. Electronic address: xichuanli@tjnu.edu.cn.

Ce Wang (C)

Department of Colorectal Surgery, Tianjin Union Medical Center, Tianjin, 300121, PR China.

Jinqian Chen (J)

Departments of Pharmacy, NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Tianjin Medical University Chu Hsien-I Memorial Hospital, Tianjin, 300134, PR China; School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, PR China.

Xia Hu (X)

Department of Agriculture Insect, Institute of Plant Protection, Tianjin Academy of Agricultural Sciences, Tianjin, 300381, PR China.

Hao Zhang (H)

Tianjin Key Laboratory of Animal and Plant Resistance, College of Life Sciences, Tianjin Normal University, Tianjin, 300387, PR China.

Zhiying Li (Z)

Tianjin Key Laboratory of Animal and Plant Resistance, College of Life Sciences, Tianjin Normal University, Tianjin, 300387, PR China.

Bei Lan (B)

School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, PR China.

Wei Zhang (W)

School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, PR China.

Yanjun Su (Y)

Department of Lung Cancer, Tianjin Lung Cancer Center, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China.

Chunze Zhang (C)

Department of Colorectal Surgery, Tianjin Union Medical Center, Tianjin, 300121, PR China. Electronic address: chunze.zhang@nankai.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzopyranes › 4H-1-Benzopyran-4-ones › Flavonoïdes › Potential interactions among myricetin and...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzopyranes › 4H-1-Benzopyran-4-ones › Flavonoïdes › Flavonols › Potential interactions among myricetin and...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Glycosyltransferase › Hexosyltransferases › Glucuronosyltransferase › Potential interactions among myricetin and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Potential interactions among myricetin and...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Microsomes › Microsomes du foie › Potential interactions among myricetin and...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides uridyliques › Uridine diphosphate › Potential interactions among myricetin and...