Stabilization of glucose-6-phosphate dehydrogenase oligomers enhances catalytic activity and stability of clinical variants.

Glucosephosphate Dehydrogenase / genetics Glucosephosphate Dehydrogenase Deficiency / genetics Humans Mutation NADP / metabolism Scattering, Small Angle X-Ray Diffraction
G6PD deficiency enzymopathy erythrocytes oligomer stabilization therapeutic strategy

Journal

The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R

Informations de publication

Date de publication:
03 2022
Historique:
received: 06 10 2021
revised: 13 01 2022
accepted: 16 01 2022
pubmed: 23 1 2022
medline: 16 4 2022
entrez: 22 1 2022
Statut: ppublish

Résumé

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a genetic trait that can cause hemolytic anemia. To date, over 150 nonsynonymous mutations have been identified in G6PD, with pathogenic mutations clustering near the dimer and/or tetramer interface and the allosteric NADP

Identifiants

DOI: 10.1016/j.jbc.2022.101610 PMID: 35065072 PMC: PMC8861134
pubmed: 35065072
pii: S0021-9258(22)00050-3
doi: 10.1016/j.jbc.2022.101610
pmc: PMC8861134
pii:
doi:

Substances chimiques

NADP 53-59-8
Glucosephosphate Dehydrogenase EC 1.1.1.49

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

101610

Subventions

Organisme : NICHD NIH HHS
ID : R01 HD084422
Pays : United States

Informations de copyright

Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Conflict of interest The authors declare that they have no conflicts of interest with the contents of this article.

Auteurs

Adriana Ann Garcia (AA)

Department of Chemical and Systems Biology, School of Medicine, Stanford University, Stanford, California, USA.

Irimpan I Mathews (II)

Stanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, California, USA.

Naoki Horikoshi (N)

Life Science Center for Survival Dynamics, University of Tsukuba, Tsukuba, Ibaraki, Japan; Biological Sciences Division, SLAC National Accelerator Laboratory, Menlo Park, California, USA; Department of Structural Biology, School of Medicine, Stanford University, Stanford, California, USA.

Tsutomu Matsui (T)

Stanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, California, USA.

Manat Kaur (M)

Department of Structural Biology, School of Medicine, Stanford University, Stanford, California, USA.

Soichi Wakatsuki (S)

Biological Sciences Division, SLAC National Accelerator Laboratory, Menlo Park, California, USA; Department of Structural Biology, School of Medicine, Stanford University, Stanford, California, USA. Electronic address: soichi.wakatsuki@stanford.edu.

Daria Mochly-Rosen (D)

Department of Chemical and Systems Biology, School of Medicine, Stanford University, Stanford, California, USA. Electronic address: mochly@stanford.edu.

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Alcohol oxidoreductases › Carbohydrate dehydrogenases › Glucose 6-phosphate dehydrogenase › Stabilization of glucose-6-phosphate...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Erreurs innées du métabolisme › Erreurs innées du métabolisme glucidique › Déficit en glucose-6-phosphate-déshydrogénase › Stabilization of glucose-6-phosphate...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Stabilization of glucose-6-phosphate...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Stabilization of glucose-6-phosphate...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides adényliques › NADP › Stabilization of glucose-6-phosphate...
questionsmedicales.fr › Phénomènes physiques › Diffusion de rayonnements › Diffusion aux petits angles › Stabilization of glucose-6-phosphate...
questionsmedicales.fr › Phénomènes chimiques › Diffraction des rayons X › Stabilization of glucose-6-phosphate...