Technical note: Validation of an ultrahigh dose rate pulsed electron beam monitoring system using a current transformer for FLASH preclinical studies.
FLASH
beam current transformer
charge
dosimetry
monitoring
ultrahigh dose rate
Journal
Medical physics
ISSN: 2473-4209
Titre abrégé: Med Phys
Pays: United States
ID NLM: 0425746
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
revised:
20
12
2021
received:
30
08
2021
accepted:
07
01
2021
pubmed:
24
1
2022
medline:
11
3
2022
entrez:
23
1
2022
Statut:
ppublish
Résumé
The Oriatron eRT6 is a linear accelerator (linac) used in FLASH preclinical studies able to reach dose rates ranging from conventional (CONV) up to ultrahigh (UHDR). This work describes the implementation of commercially available beam current transformers (BCTs) as online monitoring tools compatible with CONV and UHDR irradiations for preclinical FLASH studies. Two BCTs were used to measure the output of the Oriatron eRT6 linac. First, the correspondence between the set nominal beam parameters and those measured by the BCTs was checked. Then, we established the relationship between the total exit charge (measured by BCTs) and the absorbed dose to water. The influence of the pulse width (PW) and the pulse repetition frequency (PRF) at UHDR was characterized, as well as the short- and long-term stabilities of the relationship between the exit charge and the dose at CONV and UHDR. The BCTs were able to determine consistently the number of pulses, PW, and PRF. For fixed PW and pulse height, the exit charge measured from BCTs was correlated with the dose, and linear relationships were found with uncertainties of 0.5 % and 3 % in CONV and UHDR mode, respectively. Short- and long-term stabilities of the dose-to-charge ratio were below 1.6 %. We implemented commercially available BCTs and demonstrated their ability to act as online beam monitoring systems to support FLASH preclinical studies with CONV and UHDR irradiations. The implemented BCTs support dosimetric measurements, highlight variations among multiple measurements in a row, enable monitoring of the physics parameters used for irradiation, and are an important step for the safety of the clinical translation of FLASH radiation therapy.
Identifiants
pubmed: 35066878
doi: 10.1002/mp.15474
pmc: PMC9303205
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1831-1838Subventions
Organisme : NCI NIH HHS
ID : P01 CA244091
Pays : United States
Organisme : EMPIR program of the European Union Horizon 2020
Organisme : ISREC Foundation
Organisme : NIH HHS
ID : PO1CA244091
Pays : United States
Organisme : Synergia
ID : CRS II5_186369
Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2022 The Authors. Medical Physics published by Wiley Periodicals LLC on behalf of American Association of Physicists in Medicine.
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