Correlations between patient-specific parameters and dosimetric indices for personalized breast cancer radiotherapy.
Humans
Female
Precision Medicine
/ methods
Radiotherapy Planning, Computer-Assisted
/ methods
Breast Neoplasms
/ radiotherapy
Radiotherapy Dosage
Organs at Risk
/ radiation effects
Radiotherapy, Intensity-Modulated
/ methods
Middle Aged
Radiometry
/ methods
Heart
/ radiation effects
Aged
Adult
Lung
/ radiation effects
Tumor Burden
Conformal radiotherapy
Dosimetric parameters
Intensity modulated techniques
Organs at risk
Treatment planning
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
30 10 2024
30 10 2024
Historique:
received:
26
02
2024
accepted:
08
10
2024
medline:
31
10
2024
pubmed:
31
10
2024
entrez:
31
10
2024
Statut:
epublish
Résumé
Treatment planning parameters in radiotherapy are key elements that dictate the success of treatment outcome. While some parameters are commonly evaluated irrespective of cancer type, others are site-dependent and strongly patient specific. Given the critical influence of planning parameters on personalized therapy, the aim of this study was to evaluate the correlations between the dosimetric indices (conformity, homogeneity and mismatch indices) related to tumor coverage and the patient-specific parameters which encompass parameters pertaining to organs at risk (widths and lengths of heart and ipsilateral lung included in treatment fields, mean/maximum doses to heart, ipsilateral lung, left anterior descending aorta and contralateral breast) and tumor volume. Forty breast cancer patients were divided into two groups according to tumor location: twenty with left-sided (group A) and twenty with right-sided breast cancer (group B). Conformal (3DCRT), intensity modulated (IMRT) and volumetric arc modulated (VMAT) radiotherapy techniques were used for plan creation. Moderate to strong correlations were found for ipsilateral lung parameters for both groups of patients regardless of the treatment technique. Moderate to strong correlations were found for heart parameters in group A patients, while no correlations were observed in group B. The mismatch index presented moderate to strong correlations with tumor volume for all treatment techniques (r = -0.861 3DCRT, r = -0.556 IMRT, r = -0.533 VMAT) particularly in group A. The evaluated correlations indicate the role of dosimetric indices in personalized treatment planning.
Identifiants
pubmed: 39478060
doi: 10.1038/s41598-024-75858-4
pii: 10.1038/s41598-024-75858-4
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
26141Informations de copyright
© 2024. The Author(s).
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