Proteomic profiling in cerebral amyloid angiopathy reveals an overlap with CADASIL highlighting accumulation of HTRA1 and its substrates.
CADASIL
Cerebral amyloid angiopathy
Cerebral small vessel disease
HTRA1
Proteomics
Proteostasis
Journal
Acta neuropathologica communications
ISSN: 2051-5960
Titre abrégé: Acta Neuropathol Commun
Pays: England
ID NLM: 101610673
Informations de publication
Date de publication:
24 01 2022
24 01 2022
Historique:
received:
03
12
2021
accepted:
06
12
2021
entrez:
25
1
2022
pubmed:
26
1
2022
medline:
24
3
2022
Statut:
epublish
Résumé
Cerebral amyloid angiopathy (CAA) is an age-related condition and a major cause of intracerebral hemorrhage and cognitive decline that shows close links with Alzheimer's disease (AD). CAA is characterized by the aggregation of amyloid-β (Aβ) peptides and formation of Aβ deposits in the brain vasculature resulting in a disruption of the angioarchitecture. Capillaries are a critical site of Aβ pathology in CAA type 1 and become dysfunctional during disease progression. Here, applying an advanced protocol for the isolation of parenchymal microvessels from post-mortem brain tissue combined with liquid chromatography tandem mass spectrometry (LC-MS/MS), we determined the proteomes of CAA type 1 cases (n = 12) including a patient with hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D), and of AD cases without microvascular amyloid pathology (n = 13) in comparison to neurologically healthy controls (n = 12). ELISA measurements revealed microvascular Aβ
Identifiants
pubmed: 35074002
doi: 10.1186/s40478-021-01303-6
pii: 10.1186/s40478-021-01303-6
pmc: PMC8785498
doi:
Substances chimiques
Proteome
0
High-Temperature Requirement A Serine Peptidase 1
EC 3.4.21.-
HTRA1 protein, human
EC 3.4.21.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
6Informations de copyright
© 2022. The Author(s).
Références
Acta Neuropathol. 2015 Feb;129(2):167-82
pubmed: 25534025
J Neuropathol Exp Neurol. 2002 Mar;61(3):282-93
pubmed: 11895043
Nat Neurosci. 2015 Dec;18(12):1819-31
pubmed: 26523646
Neurobiol Aging. 2018 Oct;70:70-77
pubmed: 30007166
Acta Neuropathol Commun. 2018 Jun 4;6(1):46
pubmed: 29860944
Neurobiol Aging. 1995 May-Jun;16(3):271-8; discussion 278-84
pubmed: 7566337
Neurochem Int. 2001 Nov-Dec;39(5-6):393-400
pubmed: 11578774
Neuropathol Appl Neurobiol. 2013 Oct;39(6):593-611
pubmed: 23489283
Nat Rev Neurol. 2020 Jan;16(1):30-42
pubmed: 31827267
J Biol Chem. 2018 Mar 16;293(11):4071-4084
pubmed: 29414786
Rev Neurosci. 2014;25(5):641-51
pubmed: 24870607
Neuropathology. 2008 Apr;28(2):132-42
pubmed: 18021191
Neurology. 1991 Apr;41(4):479-86
pubmed: 2011243
Sci Rep. 2015 Nov 25;5:16923
pubmed: 26603754
Acta Neuropathol. 2010 Mar;119(3):277-90
pubmed: 20155424
Acta Neuropathol. 1991;82(4):239-59
pubmed: 1759558
Ann Neurol. 1991 Nov;30(5):637-49
pubmed: 1763890
Ann Neurol. 2016 Mar;79(3):387-403
pubmed: 26648042
Invest Ophthalmol Vis Sci. 2010 Jul;51(7):3379-86
pubmed: 20207970
Biochim Biophys Acta. 2016 May;1862(5):887-900
pubmed: 26705676
Nat Cell Biol. 2009 Nov;11(11):1325-31
pubmed: 19855388
Acta Neuropathol. 2019 May;137(5):801-823
pubmed: 30729296
Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16496-501
pubmed: 25369932
Front Aging Neurosci. 2014 Sep 19;6:251
pubmed: 25285078
PLoS One. 2011;6(8):e22959
pubmed: 21829675
J Clin Invest. 2021 Nov 15;131(22):
pubmed: 34779414
Nat Neurosci. 2019 Jul;22(7):1089-1098
pubmed: 31235908
Nat Rev Mol Cell Biol. 2011 Mar;12(3):152-62
pubmed: 21326199
Acta Neuropathol Commun. 2019 Jan 28;7(1):12
pubmed: 30691533
Sci Rep. 2017 Nov 1;7(1):14804
pubmed: 29093542
J Neuropathol Exp Neurol. 2016 Sep;75(9):868-76
pubmed: 27444354
Elife. 2016 Aug 01;5:
pubmed: 27476853
J Neurochem. 2021 Oct;159(2):273-291
pubmed: 34218440
Brain. 2017 Jul 1;140(7):1829-1850
pubmed: 28334869
Brain Pathol. 2015 Jan;25(1):63-78
pubmed: 25521178
Acta Neuropathol. 2018 Jul;136(1):111-125
pubmed: 29725820
Nat Commun. 2020 Jan 9;11(1):157
pubmed: 31919466
Lancet Neurol. 2018 Nov;17(11):1016-1024
pubmed: 30353860
J Cereb Blood Flow Metab. 2016 Jan;36(1):158-71
pubmed: 25899296
Neuropathol Appl Neurobiol. 2018 Apr;44(3):247-266
pubmed: 29380913
J Clin Invest. 2000 Mar;105(5):597-605
pubmed: 10712431
Acta Neuropathol. 2016 May;131(5):659-85
pubmed: 27062261
Biochem Soc Trans. 2019 Dec 20;47(6):1651-1660
pubmed: 31845742
Lancet Neurol. 2010 Jul;9(7):689-701
pubmed: 20610345
Neuropathol Appl Neurobiol. 2011 Feb;37(1):75-93
pubmed: 20946241
Am J Pathol. 2021 Nov;191(11):1871-1887
pubmed: 33387456
J Am Chem Soc. 2016 Aug 3;138(30):9473-8
pubmed: 27379525
Neurobiol Aging. 2009 Dec;30(12):1936-48
pubmed: 18359131
J Neuropathol Exp Neurol. 2016 Nov 1;75(11):1020-1030
pubmed: 27634960
Acta Neuropathol. 1998 Dec;96(6):628-36
pubmed: 9845293
Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):6021-6
pubmed: 15855271
Brain. 2021 Oct 22;144(9):2670-2682
pubmed: 34626176
Lancet Neurol. 2019 Jun;18(6):587-599
pubmed: 30975520
Mol Cell Proteomics. 2014 Sep;13(9):2513-26
pubmed: 24942700
Acta Neuropathol. 2017 Oct;134(4):605-617
pubmed: 28478503
Neuropathol Appl Neurobiol. 2017 Oct;43(6):492-504
pubmed: 27543695
Mol Cell Proteomics. 2015 May;14(5):1265-74
pubmed: 25713122
Brain. 2015 Aug;138(Pt 8):2347-58
pubmed: 26063658
Nat Chem Biol. 2015 Nov;11(11):862-9
pubmed: 26436840
Lancet Neurol. 2019 Jul;18(7):684-696
pubmed: 31097385
J Alzheimers Dis. 2015;43(2):535-48
pubmed: 25114073
J Biol Chem. 2012 Jun 15;287(25):20931-41
pubmed: 22535953
Exp Gerontol. 2012 Nov;47(11):816-24
pubmed: 22705146
PLoS One. 2014 Feb 26;9(2):e89970
pubmed: 24587158
Acta Neuropathol. 2018 May;135(5):681-694
pubmed: 29574591
Methods Mol Biol. 2019;1959:65-87
pubmed: 30852816
N Engl J Med. 2009 Apr 23;360(17):1729-39
pubmed: 19387015
Brain. 2013 Jun;136(Pt 6):1830-45
pubmed: 23649698
J Am Coll Cardiol. 2019 Jul 2;73(25):3326-3344
pubmed: 31248555
Acta Neuropathol. 2004 Feb;107(2):83-90
pubmed: 14655019
EMBO J. 2020 Oct 15;39(20):e105693
pubmed: 32954517
Hum Mol Genet. 2011 May 1;20(9):1800-10
pubmed: 21320870