Foodborne fluoxetine impacts the immune response in rainbow trout (Oncorhynchus mykkis).
Aquatic pollutants
Fish hematological profile
Fish immune response
Oxidative stress
SSRI
Journal
Environmental toxicology and pharmacology
ISSN: 1872-7077
Titre abrégé: Environ Toxicol Pharmacol
Pays: Netherlands
ID NLM: 9612020
Informations de publication
Date de publication:
Feb 2022
Feb 2022
Historique:
received:
07
07
2021
revised:
18
01
2022
accepted:
19
01
2022
pubmed:
26
1
2022
medline:
24
2
2022
entrez:
25
1
2022
Statut:
ppublish
Résumé
The aim of this study was to reveal the effects of foodborne fluoxetine on morphological and condition profile, hematological profile, biochemical and oxidative stress indices on juvenile rainbow trout. The study was performed according to OECD Guideline No. 215. Fluoxetine was incorporated into Biomar 921 pellets at a dose of 0.047 mg/kg (environmental concentration), 0.577 mg/kg and 6.7 mg/kg. There was statistically significant change in hematological profile, including an increasing trend in neutrophil/lymphocyte ratio and a decreasing trend in the number of lymphocytes. Measurements of oxidative stress indicated decreased activity of the detoxifying enzyme glutathione-S-transferase in the liver and kidney. However, the measurement of GR, GPx, CAT, SOD activity, and TBARS showed no changes. Histopathological examination revealed damage to the proximal tubules of caudal kidney in exposed groups. This study confirms that fluoxetine has a significant effect on immune response.
Identifiants
pubmed: 35074562
pii: S1382-6689(22)00011-4
doi: 10.1016/j.etap.2022.103818
pii:
doi:
Substances chimiques
Antidepressive Agents, Second-Generation
0
Water Pollutants, Chemical
0
Fluoxetine
01K63SUP8D
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
103818Informations de copyright
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