Planar polarity in primate cone photoreceptors: a potential role in Stiles Crawford effect phototropism.
Journal
Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179
Informations de publication
Date de publication:
24 01 2022
24 01 2022
Historique:
received:
08
02
2021
accepted:
15
12
2021
entrez:
25
1
2022
pubmed:
26
1
2022
medline:
25
3
2022
Statut:
epublish
Résumé
Human cone phototropism is a key mechanism underlying the Stiles-Crawford effect, a psychophysiological phenomenon according to which photoreceptor outer/inner segments are aligned along with the direction of incoming light. However, such photomechanical movements of photoreceptors remain elusive in mammals. We first show here that primate cone photoreceptors have a planar polarity organized radially around the optical center of the eye. This planar polarity, based on the structure of the cilium and calyceal processes, is highly reminiscent of the planar polarity of the hair cells and their kinocilium and stereocilia. Secondly, we observe under super-high resolution expansion microscopy the cytoskeleton and Usher proteins architecture in the photoreceptors, which appears to establish a mechanical continuity between the outer and inner segments. Taken together, these results suggest a comprehensive cellular mechanism consistent with an active phototropism of cones toward the optical center of the eye, and thus with the Stiles-Crawford effect.
Identifiants
pubmed: 35075261
doi: 10.1038/s42003-021-02998-y
pii: 10.1038/s42003-021-02998-y
pmc: PMC8786850
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
89Subventions
Organisme : Agence Nationale de la Recherche (French National Research Agency)
ID : ANR-15-RHU-0001
Organisme : Agence Nationale de la Recherche (French National Research Agency)
ID : ANR-10-LABX-65
Organisme : Agence Nationale de la Recherche (French National Research Agency)
ID : ANR-18-IAHU-0001
Informations de copyright
© 2022. The Author(s).
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