Epithelial miR-215 negatively modulates Th17-dominant inflammation by inhibiting CXCL12 production in the small intestine.
CXCL12
Ileitis
Th17
miR-215
microRNA
Journal
Genes to cells : devoted to molecular & cellular mechanisms
ISSN: 1365-2443
Titre abrégé: Genes Cells
Pays: England
ID NLM: 9607379
Informations de publication
Date de publication:
Apr 2022
Apr 2022
Historique:
revised:
17
01
2022
received:
16
12
2021
accepted:
20
01
2022
pubmed:
26
1
2022
medline:
13
4
2022
entrez:
25
1
2022
Statut:
ppublish
Résumé
MicroRNAs are a class of non-coding short-chained RNAs that control cellular functions by downregulating their target genes. Recent research indicates that microRNAs play a role in the maintenance of gut homeostasis. miR-215 was found to be highly expressed in epithelial cells of the small intestine; however, the involvement of miR-215 in gut immunity remains unknown. Here, we show that miR-215 negatively regulates inflammation in the small intestine by inhibiting CXCL12 production. Mice lacking miR-215 showed high susceptibility to inflammation induced by indomethacin, accompanied by an increased number of Th17 cells in the lamina propria of the small intestine. Our findings provide a rationale for targeting miR-215 as a therapeutic intervention for inflammatory conditions in the small intestine.
Substances chimiques
MicroRNAs
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
243-253Subventions
Organisme : Ministry of Education, Culture, Sports, Science, and Technology of Japan
Organisme : Japan Agency for Medical Research and Development
Informations de copyright
© 2022 Molecular Biology Society of Japan and John Wiley & Sons Australia, Ltd.
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