Adaptive differentiation for fast barrier restoration.

Cell Differentiation Intestinal Mucosa Stem Cells

Journal

Developmental cell
ISSN: 1878-1551
Titre abrégé: Dev Cell
Pays: United States
ID NLM: 101120028

Informations de publication

Date de publication:
24 01 2022
Historique:
entrez: 25 1 2022
pubmed: 26 1 2022
medline: 10 2 2022
Statut: ppublish

Résumé

Epithelial regeneration can be mediated through activation of stem cells or de-differentiation of post-mitotic cells. In this issue of Developmental Cell, Ohara et al. report that regeneration of damaged intestinal villi occurs via a yes-associated protein 1 (YAP)-dependent adaptive differentiation of transit-amplifying progenitors to a fetal-like state that restores intestinal barrier function.

Identifiants

DOI: 10.1016/j.devcel.2021.12.024 PMID: 35077677
pubmed: 35077677
pii: S1534-5807(21)01060-1
doi: 10.1016/j.devcel.2021.12.024
pii:
doi:

Types de publication

Journal Article Comment

Langues

eng

Sous-ensembles de citation

IM

Pagination

147-148

Commentaires et corrections

Type : CommentOn

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

Auteurs

Qiutan Yang (Q)

Friedrich Miescher Institute for Biomedical Research (FMI), Maulbeerstrasse 66, 4058 Basel, Switzerland.

Prisca Liberali (P)

Friedrich Miescher Institute for Biomedical Research (FMI), Maulbeerstrasse 66, 4058 Basel, Switzerland. Electronic address: prisca.liberali@fmi.ch.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Adaptive differentiation for fast barrier restoration.
questionsmedicales.fr › Tissus › Membranes › Muqueuse › Muqueuse intestinale › Adaptive differentiation for fast barrier restoration.
questionsmedicales.fr › Cellules › Cellules souches › Adaptive differentiation for fast barrier restoration.