Genetics in aphasia recovery.

Aphasia / genetics Genome-Wide Association Study Humans Language Recovery of Function / genetics Stroke / genetics
Aphasia BDNF GWAS Genetics Recovery Stroke

Journal

Handbook of clinical neurology
ISSN: 0072-9752
Titre abrégé: Handb Clin Neurol
Pays: Netherlands
ID NLM: 0166161

Informations de publication

Date de publication:
2022
Historique:
entrez: 26 1 2022
pubmed: 27 1 2022
medline: 28 1 2022
Statut: ppublish

Résumé

Considerable research efforts have been exerted toward understanding the mechanisms underlying recovery in aphasia. However, predictive models of spontaneous and treatment-induced recovery remain imprecise. Some of the hitherto unexplained variability in recovery may be accounted for with genetic data. A few studies have examined the effects of the BDNF val66met polymorphism on aphasia recovery, yielding mixed results. Advances in the study of stroke genetics and genetics of stroke recovery, including identification of several susceptibility genes through candidate-gene or genome-wide association studies, may have implications for the recovery of language function. The current chapter discusses both the direct and indirect evidence for a genetic basis of aphasia recovery, the implications of recent findings within the field, and potential future directions to advance understanding of the genetics-recovery associations.

Identifiants

DOI: 10.1016/B978-0-12-823384-9.00015-3 PMID: 35078606
pubmed: 35078606
pii: B978-0-12-823384-9.00015-3
doi: 10.1016/B978-0-12-823384-9.00015-3
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

283-296

Informations de copyright

Copyright © 2022 Elsevier B.V. All rights reserved.

Auteurs

Sigfus Kristinsson (S)

Department of Communication Sciences and Disorders, University of South Carolina, Columbia, SC, United States.

Julius Fridriksson (J)

Department of Communication Sciences and Disorders, University of South Carolina, Columbia, SC, United States. Electronic address: fridriks@mailbox.sc.edu.

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Classifications MeSH

questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Troubles du langage › Troubles de la parole › Aphasie › Genetics in aphasia recovery.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › Genetics in aphasia recovery.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Genetics in aphasia recovery.
questionsmedicales.fr › Sciences de l'information › Langage › Genetics in aphasia recovery.
questionsmedicales.fr › Phénomènes biologiques › Récupération fonctionnelle › Genetics in aphasia recovery.
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Angiopathies intracrâniennes › Accident vasculaire cérébral › Genetics in aphasia recovery.