ACTN3 (R577X) Genotype Is Associated With Australian Football League Players.
Journal
Journal of strength and conditioning research
ISSN: 1533-4287
Titre abrégé: J Strength Cond Res
Pays: United States
ID NLM: 9415084
Informations de publication
Date de publication:
01 Feb 2022
01 Feb 2022
Historique:
entrez:
26
1
2022
pubmed:
27
1
2022
medline:
28
1
2022
Statut:
ppublish
Résumé
Jacob, Y, Hart, NH, Cochrane, JL, Spiteri, T, Laws, SM, Jones, A, Rogalski, B, Kenna, J, and Anderton, RS. ACTN3 (R577X) genotype is associated with Australian Football League players. J Strength Cond Res 36(2): 573-576, 2022-Genetic variants in the angiotensin-converting enzyme (ACE) and alpha actinin-3 (ACTN3) genes have been associated with elite sport athletic performance. This study aimed to investigate the frequency of each polymorphism in a cohort of elite Australian football (AF) players. To achieve this, 47 players from an Australian Football League (AFL) club and 59 healthy age matched controls with no history of elite sporting competition were recruited for this study. Each subject provided saliva samples through buccal swab for DNA extraction and genotyping, with group comparisons made using χ2 and odds ratio analysis. There was no significant difference in ACE I/D genotype between healthy control and elite AF players. The ACTN3 XX genotype was significantly underrepresented in AFL players (4.3%) compared with healthy controls (28.8%, p = 0.003). In addition, there was a greater representation of the R allele in elite AF players (70.2%) when compared with healthy controls (50%; χ2 = 8.834, p = 0.002). This is the first study to investigate genetic variants in elite AF players, with results suggesting that the ACTN3 gene may play a significant role explaining aspects of athletic performance in AF.
Identifiants
pubmed: 35080207
doi: 10.1519/JSC.0000000000003458
pii: 00124278-202202000-00042
doi:
Substances chimiques
Actinin
11003-00-2
ACTN3 protein, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
573-576Informations de copyright
Copyright © 2020 National Strength and Conditioning Association.
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