Eosinophils and eosinophilic immune dysfunction in health and disease.
Journal
European respiratory review : an official journal of the European Respiratory Society
ISSN: 1600-0617
Titre abrégé: Eur Respir Rev
Pays: England
ID NLM: 9111391
Informations de publication
Date de publication:
31 Mar 2022
31 Mar 2022
Historique:
received:
30
06
2021
accepted:
22
10
2021
entrez:
27
1
2022
pubmed:
28
1
2022
medline:
29
1
2022
Statut:
epublish
Résumé
The functions ascribed to eosinophils have classically been limited to host defence against certain parasitic infections and potentially deleterious effects in the setting of specific diseases that are associated with elevated eosinophil counts in blood and/or tissue. The ability to induce eosinophil depletion either experimentally in animal models or through targeted therapies in humans has extended our understanding of the roles played by eosinophils in health and homeostasis as well as in disease pathogenesis. When associated with human disease aetiology, the eosinophil takes on a pathogenic rather than a protective role. This maladaptive response, called "eosinophilic immune dysfunction" herein, appears central to exacerbation pathogenesis and disease control in severe asthma and may be involved in the aetiology of other eosinophil-related conditions ranging from organ-system-limited diseases such as phenotypic subsets of chronic obstructive pulmonary disease and chronic rhinosinusitis with nasal polyposis to more broadly systemic diseases such as eosinophilic granulomatosis with polyangiitis and hypereosinophilic syndrome. In this review, we describe the evidence supporting eosinophilic functions related to health and homeostasis and explore the contribution of eosinophilic immune dysfunction to human disease.
Identifiants
pubmed: 35082127
pii: 31/163/210150
doi: 10.1183/16000617.0150-2021
pmc: PMC9489126
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright ©The authors 2022.
Déclaration de conflit d'intérêts
Conflict of interest: D.J. Jackson has received consulting, speaker fees, and support to attend international congresses from AstraZeneca, GSK, Sanofi, Teva, BI, Novartis, Chiesi, and Napp. Conflict of interest: P. Akuthota has received consulting fees and research support from AstraZeneca, GlaxoSmithKline, and Regeneron; consulting fees from Advance Medical; grant support from the National Institutes of Health (US); royalties from UpToDate; and honoraria from Medscape/WebMD, AKH, Prime CME, Rockpointe, and Vindico. Conflict of interest: F. Roufosse has received consulting fees from AstraZeneca, GlaxoSmithKline, and Knopp Biosciences for drug development in hypereosinophilic syndromes and royalties from UpToDate.
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