The pH-Dependence of the Hydration of 5-Formylcytosine: an Experimental and Theoretical Study.
DNA methylation
TET enzymes
aldehyde hydrates
computational chemistry
epigenetics
modified nucleic acids
Journal
Chembiochem : a European journal of chemical biology
ISSN: 1439-7633
Titre abrégé: Chembiochem
Pays: Germany
ID NLM: 100937360
Informations de publication
Date de publication:
05 04 2022
05 04 2022
Historique:
revised:
24
01
2022
received:
25
11
2021
pubmed:
28
1
2022
medline:
8
4
2022
entrez:
27
1
2022
Statut:
ppublish
Résumé
5-Formylcytosine is an important nucleobase in epigenetic regulation, whose hydrate form has been implicated in the formation of 5-carboxycytosine as well as oligonucleotide binding events. The hydrate content of 5-formylcytosine and its uracil derivative has now been quantified using a combination of NMR and mass spectroscopic measurements as well as theoretical studies. Small amounts of hydrate can be identified for the protonated form of 5-formylcytosine and for neutral 5-formyluracil. For neutral 5-formylcytosine, however, direct detection of the hydrate was not possible due to its very low abundance. This is in full agreement with theoretical estimates.
Identifiants
pubmed: 35084086
doi: 10.1002/cbic.202100651
pmc: PMC9304204
doi:
Substances chimiques
5-formylcytosine
0
Cytosine
8J337D1HZY
DNA
9007-49-2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e202100651Informations de copyright
© 2022 The Authors. ChemBioChem published by Wiley-VCH GmbH.
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