The importance of accessory protein variants in the pathogenicity of SARS-CoV-2.

COVID-19 / pathology Genetic Variation Humans Phylogeny SARS-CoV-2 / genetics Viral Proteins / genetics Viroporin Proteins / genetics
ORF10 ORF3a ORF6 ORF7a ORF7b ORF8 Pathogenicity SARS-CoV-2

Journal

Archives of biochemistry and biophysics
ISSN: 1096-0384
Titre abrégé: Arch Biochem Biophys
Pays: United States
ID NLM: 0372430

Informations de publication

Date de publication:
15 03 2022
Historique:
received: 02 11 2021
revised: 15 01 2022
accepted: 17 01 2022
pubmed: 28 1 2022
medline: 15 2 2022
entrez: 27 1 2022
Statut: ppublish

Résumé

The coronavirus disease 2019 (COVID-19) is caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS- CoV-2) with an estimated fatality rate of less than 1%. The SARS-CoV-2 accessory proteins ORF3a, ORF6, ORF7a, ORF7b, ORF8, and ORF10 possess putative functions to manipulate host immune mechanisms. These involve interferons, which appear as a consensus function, immune signaling receptor NLRP3 (NLR family pyrin domain-containing 3) inflammasome, and inflammatory cytokines such as interleukin 1β (IL-1β) and are critical in COVID-19 pathology. Outspread variations of each of the six accessory proteins were observed across six continents of all complete SARS-CoV-2 proteomes based on the data reported before November 2020. A decreasing order of percentage of unique variations in the accessory proteins was determined as ORF3a > ORF8 > ORF7a > ORF6 > ORF10 > ORF7b across all continents. The highest and lowest unique variations of ORF3a were observed in South America and Oceania, respectively. These findings suggest that the wide variations in accessory proteins seem to affect the pathogenicity of SARS-CoV-2.

Identifiants

DOI: 10.1016/j.abb.2022.109124 PMID: 35085577 PMC: PMC8785432
pubmed: 35085577
pii: S0003-9861(22)00009-1
doi: 10.1016/j.abb.2022.109124
pmc: PMC8785432
pii:
doi:

Substances chimiques

ORF3a protein, SARS-CoV-2 0
ORF6 protein, SARS-CoV-2 0
ORF7a protein, SARS-CoV-2 0
ORF7b protein, SARS-CoV-2 0
ORF8 protein, SARS-CoV-2 0
Viral Proteins 0
Viroporin Proteins 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

109124

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

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Auteurs

Sk Sarif Hassan (SS)

Department of Mathematics, Pingla Thana Mahavidyalaya, Maligram, 721140, India. Electronic address: sarimif@gmail.com.

Pabitra Pal Choudhury (PP)

Applied Statistics Unit, Indian Statistical Institute, Kolkata, 700108, West Bengal, India.

Guy W Dayhoff (GW)

Department of Chemistry, College of Art and Sciences, University of South Florida, Tampa, FL, 33620, USA.

Alaa A A Aljabali (AAA)

Department of Pharmaceutics and Pharmaceutical Technology, Yarmouk University-Faculty of Pharmacy, Irbid, 566, Jordan.

Bruce D Uhal (BD)

Department of Physiology, Michigan State University, East Lansing, MI, 48824, USA.

Kenneth Lundstrom (K)

PanTherapeutics, Rte de Lavaux 49, CH1095, Lutry, Switzerland. Electronic address: lundstromkenneth@gmail.com.

Nima Rezaei (N)

Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran; Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Stockholm, Sweden.

Damiano Pizzol (D)

Italian Agency for Development Cooperation - Khartoum, Sudan Street 33, Al Amarat, Sudan.

Parise Adadi (P)

Department of Food Science, University of Otago, Dunedin, 9054, New Zealand.

Amos Lal (A)

Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, USA.

Antonio Soares (A)

Department of Cellular and Integrative Physiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX, 78229-3900, USA.

Tarek Mohamed Abd El-Aziz (T)

Department of Cellular and Integrative Physiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX, 78229-3900, USA; Zoology Department, Faculty of Science, Minia University, El-Minia, 61519, Egypt.

Adam M Brufsky (AM)

University of Pittsburgh School of Medicine, Department of Medicine, Division of Hematology/Oncology, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.

Gajendra Kumar Azad (GK)

Department of Zoology, Patna University, Patna, 800005, Bihar, India.

Samendra P Sherchan (SP)

Department of Environmental Health Sciences, Tulane University, New Orleans, LA, 70112, USA.

Wagner Baetas-da-Cruz (W)

Translational Laboratory in Molecular Physiology, Centre for Experimental Surgery, College of Medicine, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.

Kazuo Takayama (K)

Center for iPS Cell Research and Application, Kyoto University, Japan.

Ãngel Serrano-Aroca (Ã)

Biomaterial and Bioengineering Lab, Translational Research Centre San Alberto Magno, Catholic University of Valencia San Vicente M'artir, c/Guillem de Castro 94, 46001, Valencia, Spain.

Gaurav Chauhan (G)

School of Engineering and Sciences, Tecnologico de Monterrey, Av. Eugenio Garza Sada 2501 Sur, 64849, Monterrey, Nuevo León, Mexico.

Giorgio Palu (G)

Department of Molecular Medicine, University of Padova, Via Gabelli 63, 35121, Padova, Italy.

Yogendra Kumar Mishra (YK)

University of Southern Denmark, Mads Clausen Institute, NanoSYD, Alsion 2, 6400, Sønderborg, Denmark.

Debmalya Barh (D)

Centre for Genomics and Applied Gene Technology, Institute of Integrative Omics and Applied Biotechnology (IIOAB), Nonakuri, Purba Medinipur, WB, India; Departamento de Genética, Ecologia e Evolucao, Instituto de Cîencias Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.

Raner Jośe Santana Silva (RJ)

Departamento de Ciencias Biologicas (DCB), Programa de Pos-Graduacao em Genetica e Biologia Molecular (PPGGBM), Universidade Estadual de Santa Cruz (UESC), Rodovia Ilheus-Itabuna, km 16, 45662-900, Ilheus, BA, Brazil.

Bruno Silva Andrade (BS)

Laboratório de Bioinformática e Química Computacional, Departamento de Ciências Biológicas, Universidade Estadual do Sudoeste da Bahia (UESB), Jequié, 45206-190, Brazil.

Vasco Azevedo (V)

Departamento de Genética, Ecologia e Evolucao, Instituto de Cîencias Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.

Aristóteles Góes-Neto (A)

Laboratório de Biologia Molecular e Computacional de Fungos, Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.

Nicolas G Bazan (NG)

Neuroscience Center of Excellence, School of Medicine, LSU Health New Orleans, New Orleans, LA, 70112, USA.

Elrashdy M Redwan (EM)

King Abdulaz University, Faculty of Science, Department of Biological Science, Saudi Arabia.

Murtaza Tambuwala (M)

School of Pharmacy and Pharmaceutical Science, Ulster University, Coleraine, BT52 1SA, Northern Ireland, UK.

Vladimir N Uversky (VN)

Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, 33612, USA; Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Institutskiy pereulok, 9, Dolgoprudny, 141700, Moscow region, Russia. Electronic address: vuversky@usf.edu.

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Classifications MeSH

questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › The importance of accessory protein variants...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › The importance of accessory protein variants...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The importance of accessory protein variants...
questionsmedicales.fr › Sciences de l'information › Phylogenèse › The importance of accessory protein variants...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › The importance of accessory protein variants...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines virales › The importance of accessory protein variants...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines virales › Protéines virales structurales › Protéines de l'enveloppe virale › Protéines viroporines › The importance of accessory protein variants...