Evaluation of Hyperandrogenism in Children with Autism Spectrum Disorder.
Autism
Children
Hyperandrogenism
Journal
Indian journal of pediatrics
ISSN: 0973-7693
Titre abrégé: Indian J Pediatr
Pays: India
ID NLM: 0417442
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
received:
23
07
2021
accepted:
12
11
2021
pubmed:
29
1
2022
medline:
22
6
2022
entrez:
28
1
2022
Statut:
ppublish
Résumé
This study evaluated 32 children (mean age: 8.5 y) with autism spectrum disorder (ASD) and 23 healthy controls (similar age, sex, and Tanner stage) for hyperandrogenism. These children underwent sexual maturity rating (Tanner staging), ASD severity assessment (Childhood Autism Rating Scale), and quantitative estimation for plasma testosterone, dehydroepiandrosterone sulfate (DHEAS), and androstenedione. There was no significant difference in androgen levels in the two groups. Elevated (> 95 centiles) testosterone, DHEAS, and androstenedione levels were seen in 12.3%, 6.2%, and 9% children with ASD, and 7/9 of these children (78%) with hyperandrogenism had severe ASD. However, there was no significant correlation between ASD severity and androgen levels.
Identifiants
pubmed: 35089488
doi: 10.1007/s12098-022-04080-9
pii: 10.1007/s12098-022-04080-9
doi:
Substances chimiques
Androgens
0
Testosterone
3XMK78S47O
Androstenedione
409J2J96VR
Dehydroepiandrosterone
459AG36T1B
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
717-719Informations de copyright
© 2022. Dr. K C Chaudhuri Foundation.
Références
Chauhan A, Sahu JK, Jaiswal N, et al. Prevalence of autism spectrum disorder in Indian children: a systematic review and meta-analysis. Neurol India. 2019;67:100–4.
pubmed: 30860104
Gulati S, Kaushik JS, Saini L, et al. Development and validation of DSM-5 based diagnostic tool for children with autism spectrum disorder. PLoS One. 2019;14:e0213242.
Patra S, Kar SK. Autism spectrum disorder in India: a scoping review. Int Rev Psychiatry. 2021;33:81–112.
doi: 10.1080/09540261.2020.1761136
Ferri SL, Abel T, Brodkin ES. Sex differences in autism spectrum disorder: a review. Curr Psychiatry Rep. 2018;20:9.
doi: 10.1007/s11920-018-0874-2
Baron-Cohen S, Auyeung B, Nørgaard-Pedersen B, et al. Elevated fetal steroidogenic activity in autism. Mol Psychiatry. 2015;20:369–76.
doi: 10.1038/mp.2014.48
Janšáková K, Hill M, Čelárová D, et al. Alteration of the steroidogenesis in boys with autism spectrum disorders. Transl Psychiatry. 2020;10:340.
doi: 10.1038/s41398-020-01017-8
Geier DA, Geier MR. A prospective assessment of androgen levels in patients with autistic spectrum disorders: biochemical underpinnings and suggested therapies. Neuro Endocrinol Lett. 2007;28:565–73.
pubmed: 17984958
Croonenberghs J, Van Grieken S, Wauters A, et al. Serum testosterone concentration in male autistic youngsters. Neuro Endocrinol Lett. 2010;31:483–8.
pubmed: 20802443
El-Baz F, Hamza RT, Ayad MS, Mahmoud NH. Hyperandrogenemia in male autistic children and adolescents: relation to disease severity. Int J Adolesc Med Health. 2014;26:79–84.
doi: 10.1515/ijamh-2012-0116
American Psychiatric Association. Diagnostic and statistical manual of mental disorders: DSM-5. Arlington, VA. 2013. Available at: http://repository.poltekkes-kaltim.ac.id. Accessed on 22 July 2021.