A case of convergent evolution: Several viral and bacterial pathogens hijack RSK kinases through a common linear motif.
Bacteria
/ pathogenicity
Bacterial Infections
/ genetics
Biological Evolution
Cell Line
Gene Expression Regulation, Viral
/ genetics
Host Microbial Interactions
/ genetics
Humans
Immediate-Early Proteins
/ genetics
MAP Kinase Signaling System
/ physiology
Mitogen-Activated Protein Kinase Kinases
/ metabolism
Ribosomal Protein S6 Kinases, 90-kDa
/ genetics
Virus Diseases
/ genetics
Virus Replication
/ physiology
Viruses
/ pathogenicity
host–pathogen interaction
innate immunity
picornavirus
short linear motif
type-3 secretion
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
01 02 2022
01 02 2022
Historique:
accepted:
29
11
2021
entrez:
29
1
2022
pubmed:
30
1
2022
medline:
26
2
2022
Statut:
ppublish
Résumé
Microbes have been coevolving with their host for millions of years, exploiting host resources to their own benefit. We show that viral and bacterial pathogens convergently evolved to hijack cellular mitogen-activated protein kinase (MAPK) p90-ribosomal S6-kinases (RSKs). Theiler's virus leader (L) protein binds RSKs and prevents their dephosphorylation, thus maintaining the kinases active. Recruitment of RSKs enables L-protein-mediated inhibition of eukaryotic translation initiation factor 2 alpha kinase 2 (EIF2AK2 or PKR) and stress granule formation. Strikingly, ORF45 protein of Kaposi's sarcoma-associated herpesvirus (KSHV) and YopM protein of
Identifiants
pubmed: 35091472
pii: 2114647119
doi: 10.1073/pnas.2114647119
pmc: PMC8812568
pii:
doi:
Substances chimiques
Immediate-Early Proteins
0
Ribosomal Protein S6 Kinases, 90-kDa
EC 2.7.11.1
Mitogen-Activated Protein Kinase Kinases
EC 2.7.12.2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2022 the Author(s). Published by PNAS.
Déclaration de conflit d'intérêts
Competing interest statement: Y.H. received a salary from Otsuka Pharmaceutical Co., Ltd., Tokushima, Japan, while working as guest scientist at the Université Catholique de Louvain. The company had no influence on the research project.
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