Immune mechanisms in oral lichen planus.
T cell
antigen presenting cell
keratinocyte
mast cell
oral disease
oral lichen planus
Journal
Oral diseases
ISSN: 1601-0825
Titre abrégé: Oral Dis
Pays: Denmark
ID NLM: 9508565
Informations de publication
Date de publication:
May 2023
May 2023
Historique:
revised:
12
01
2022
received:
17
10
2021
accepted:
17
01
2022
medline:
21
4
2023
pubmed:
30
1
2022
entrez:
29
1
2022
Statut:
ppublish
Résumé
Oral lichen planus (OLP) is a T cell-mediated inflammatory disease of the oral mucosa that has been extensively researched over many years but as yet the mechanisms of pathogenesis are still not fully understood. Whilst the specific aetiological factors driving OLP remain ambiguous, evidence points to the development of a chronic, dysregulated immune response to OLP-mediating antigens presented by innate immune cells and oral keratinocytes leading to increased cytokine, chemokine and adhesion molecule expression. These molecules recruit T cells and mast cells to the diseased site and orchestrate a complex interplay between cells that culminates in keratinocyte cell death, mucosal basement membrane destruction and long-term chronicity of the disease. The main lymphocytes involved are thought to be CD8+ cytotoxic and CD4+ Th1 polarised T cells although recent evidence indicates the involvement of other Th subsets such as Th9, Th17 and Tregs, suggesting that a more complex immune cell relationship exists during the disease process. This review provides an overview of the immune mechanisms at play in OLP pathogenesis with particular emphasis on the role of the different Th subsets and how these recent discoveries may guide research towards identifying potential therapeutic targets.
Substances chimiques
Cytokines
0
Types de publication
Journal Article
Review
Langues
eng
Pagination
1400-1415Informations de copyright
© 2022 Wiley Periodicals LLC.
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