Optimism is associated with respiratory symptoms and functional status in chronic obstructive pulmonary disease.
Aged
Aged, 80 and over
Comorbidity
Cross-Sectional Studies
Disease Progression
Female
Follow-Up Studies
Forced Expiratory Volume
/ physiology
Forecasting
Functional Status
Humans
Lung
/ physiopathology
Male
Middle Aged
Pulmonary Disease, Chronic Obstructive
/ diagnosis
Quality of Life
Retrospective Studies
Severity of Illness Index
Smoking
/ adverse effects
Spirometry
Surveys and Questionnaires
COPD
Dyspnea
Exacerbation
Optimism
Quality of life
Journal
Respiratory research
ISSN: 1465-993X
Titre abrégé: Respir Res
Pays: England
ID NLM: 101090633
Informations de publication
Date de publication:
29 Jan 2022
29 Jan 2022
Historique:
received:
01
05
2021
accepted:
28
12
2021
entrez:
30
1
2022
pubmed:
31
1
2022
medline:
22
3
2022
Statut:
epublish
Résumé
Optimism is the general belief that good things will occur in the future; optimism is modifiable by cognitive behavioral therapy (CBT). Previous studies have associated higher optimism with improved health outcomes and lower all-cause mortality. Investigate association between optimism and disease-related characteristics in chronic obstructive pulmonary disease (COPD). Current and former smokers with/without COPD and Preserved Ratio Impaired Spirometry (PRISm) from the 10-year follow-up visit for the Genetic Epidemiology of COPD (COPDGene) study were included. Optimism was assessed at the 10-year visit using the Life Orientation Test-Revised. Models of optimism as a predictor of lung function, COPD-associated phenotypes including exacerbations, and functional assessments, were adjusted for demographic confounders, smoking status, and comorbidities. Among 1967 subjects, higher optimism was significantly associated with older age, non-Hispanic white race, marital status, quitting smoking status, absence of COPD, and absence of depression. In multivariable analysis, higher optimism was independently associated with fewer prior exacerbations of COPD (coef = - 0.037, P < 0.001). Higher optimism was also related to better MMRC scores (coef = - 0.041, P < 0.001), CAT scores (coef = - 0.391, P < 0.001), SGRQ scores (coef = - 0.958, P < 0.001), BODE index (coef = - 0.059, P < 0.001), and longer 6-min walk distance (coef = 10.227, P < 0.001). After stratification by severity of COPD, these associations with optimism were still significant in all groups. No significant association was observed for cross-sectional FEV Fewer exacerbations and less severe respiratory symptoms and higher functional capacity were associated with higher optimism, which may impact health outcomes in current and former smokers with and without COPD. Optimism is a modifiable trait and these results may further support a role for CBT to improve outcomes in COPD.
Sections du résumé
BACKGROUND
BACKGROUND
Optimism is the general belief that good things will occur in the future; optimism is modifiable by cognitive behavioral therapy (CBT). Previous studies have associated higher optimism with improved health outcomes and lower all-cause mortality.
RESEARCH QUESTION
OBJECTIVE
Investigate association between optimism and disease-related characteristics in chronic obstructive pulmonary disease (COPD).
STUDY DESIGN AND METHODS
METHODS
Current and former smokers with/without COPD and Preserved Ratio Impaired Spirometry (PRISm) from the 10-year follow-up visit for the Genetic Epidemiology of COPD (COPDGene) study were included. Optimism was assessed at the 10-year visit using the Life Orientation Test-Revised. Models of optimism as a predictor of lung function, COPD-associated phenotypes including exacerbations, and functional assessments, were adjusted for demographic confounders, smoking status, and comorbidities.
RESULTS
RESULTS
Among 1967 subjects, higher optimism was significantly associated with older age, non-Hispanic white race, marital status, quitting smoking status, absence of COPD, and absence of depression. In multivariable analysis, higher optimism was independently associated with fewer prior exacerbations of COPD (coef = - 0.037, P < 0.001). Higher optimism was also related to better MMRC scores (coef = - 0.041, P < 0.001), CAT scores (coef = - 0.391, P < 0.001), SGRQ scores (coef = - 0.958, P < 0.001), BODE index (coef = - 0.059, P < 0.001), and longer 6-min walk distance (coef = 10.227, P < 0.001). After stratification by severity of COPD, these associations with optimism were still significant in all groups. No significant association was observed for cross-sectional FEV
INTERPRETATION
CONCLUSIONS
Fewer exacerbations and less severe respiratory symptoms and higher functional capacity were associated with higher optimism, which may impact health outcomes in current and former smokers with and without COPD. Optimism is a modifiable trait and these results may further support a role for CBT to improve outcomes in COPD.
Identifiants
pubmed: 35093071
doi: 10.1186/s12931-021-01922-6
pii: 10.1186/s12931-021-01922-6
pmc: PMC8800351
doi:
Types de publication
Journal Article
Multicenter Study
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
19Subventions
Organisme : NHLBI NIH HHS
ID : U01 HL089897
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL089856
Pays : United States
Informations de copyright
© 2022. The Author(s).
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