Immunopathology caused by impaired CD8

CD8+ T cells T-cell exhaustion chronic viral hepatitis immunopathology primary hemophagocytic lymphohistiocytosis

Journal

European journal of immunology
ISSN: 1521-4141
Titre abrégé: Eur J Immunol
Pays: Germany
ID NLM: 1273201

Informations de publication

Date de publication:
09 2022
Historique:
revised: 16 11 2021
received: 16 11 2021
accepted: 24 01 2022
pubmed: 1 2 2022
medline: 9 9 2022
entrez: 31 1 2022
Statut: ppublish

Résumé

Recent findings indicate that many immunopathologies are at their roots a consequence of impaired immune responses ("too little" immunity) and not the result of primarily exaggerated immune responses ("too much" immunity). We have summarized this conceptional view as "IMPATH paradox." In this review, we will focus on impaired immune reactions in the context of CD8

Identifiants

pubmed: 35099807
doi: 10.1002/eji.202149528
doi:

Types de publication

Journal Article Review Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1390-1395

Informations de copyright

© 2022 The Authors. European Journal of Immunology published by Wiley-VCH GmbH.

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Auteurs

Peter Aichele (P)

Institute for Immunodeficiency, Faculty of Medicine, Medical Center-University of Freiburg, Freiburg, Germany.
Center for Chronic Immunodeficiency (CCI), Faculty of Medicine, Medical Center-University of Freiburg, Freiburg, Germany.

Christoph Neumann-Haefelin (C)

Department of Medicine II (Gastroenterology, Hepatology, Endocrinology and Infectious Diseases), Faculty of Medicine, Medical Center-University of Freiburg, Freiburg, Germany.

Stephan Ehl (S)

Institute for Immunodeficiency, Faculty of Medicine, Medical Center-University of Freiburg, Freiburg, Germany.
Center for Chronic Immunodeficiency (CCI), Faculty of Medicine, Medical Center-University of Freiburg, Freiburg, Germany.

Robert Thimme (R)

Department of Medicine II (Gastroenterology, Hepatology, Endocrinology and Infectious Diseases), Faculty of Medicine, Medical Center-University of Freiburg, Freiburg, Germany.

Toni Cathomen (T)

Center for Chronic Immunodeficiency (CCI), Faculty of Medicine, Medical Center-University of Freiburg, Freiburg, Germany.
Institute for Transfusion Medicine and Gene Therapy, Medical Center-University of Freiburg, Freiburg, Germany.

Melanie Boerries (M)

Institute of Medical Bioinformatics and Systems Medicine, Faculty of Medicine, Medical Center-University of Freiburg, Freiburg, Germany.
German Cancer Consortium (DKTK), Partner Site Freiburg, and German Cancer Research Center (DKFZ), Heidelberg, Germany.

Maike Hofmann (M)

Department of Medicine II (Gastroenterology, Hepatology, Endocrinology and Infectious Diseases), Faculty of Medicine, Medical Center-University of Freiburg, Freiburg, Germany.

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