Cerium oxide nanoparticles administration during machine perfusion of discarded human livers: A pilot study.
Journal
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
ISSN: 1527-6473
Titre abrégé: Liver Transpl
Pays: United States
ID NLM: 100909185
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
revised:
10
01
2022
received:
07
10
2021
accepted:
20
01
2022
pubmed:
1
2
2022
medline:
22
6
2022
entrez:
31
1
2022
Statut:
ppublish
Résumé
The combined approach of ex situ normothermic machine perfusion (NMP) and nanotechnology represents a strategy to mitigate ischemia/reperfusion injury in liver transplantation (LT). We evaluated the uptake, distribution, and efficacy of antioxidant cerium oxide nanoparticles (nanoceria) during normothermic perfusion of discarded human livers. A total of 9 discarded human liver grafts were randomized in 2 groups and underwent 4 h of NMP: 5 grafts were treated with nanoceria conjugated with albumin (Alb-NC; 50 µg/ml) and compared with 4 untreated grafts. The intracellular uptake of nanoceria was analyzed by electron microscopy (EM) and inductively coupled plasma-mass spectrometry (ICP-MS). The antioxidant activity of Alb-NC was assayed in liver biopsies by glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT) assay, telomere length, and 4977-bp common mitochondrial DNA deletion (mtDNA
Identifiants
pubmed: 35100468
doi: 10.1002/lt.26421
pii: 01445473-202207000-00010
doi:
Substances chimiques
Antioxidants
0
Cytokines
0
DNA, Mitochondrial
0
Cerium
30K4522N6T
ceric oxide
619G5K328Y
Superoxide Dismutase
EC 1.15.1.1
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1173-1185Informations de copyright
© 2022 American Association for the Study of Liver Diseases.
Références
Guichelaar MMJ, Benson JT, Malinchoc M, Krom RAF, Wiesner RH, Charlton MR. Risk factors for and clinical course of non‐anastomotic biliary strictures after liver transplantation. Am J Transplant. 2003;3:885–90.
Zhai Y, Petrowsky H, Hong JC, Busuttil RW, Kupiec‐Weglinski JW. Ischaemia‐reperfusion injury in liver transplantation—from bench to bedside. Nat Rev Gastroenterol Hepatol. 2013;10:79–89.
Busquets J, Xiol X, Figueras J, Jaurrieta E, Torras J, Ramos E, et al. The impact of donor age on liver transplantation: influence of donor age on early liver function and on subsequent patient and graft survival. Transplantation. 2001;71:1765–71.
Dasari BV, Mergental H, Isaac JR, Muiesan P, Mirza DF, Perera T. Systematic review and meta‐analysis of liver transplantation using grafts from deceased donors aged over 70 years. Clin Transplant. 2017;31:e1319.
Ghinolfi D, Rreka E, De Tata V, Franzini M, Pezzati D, Fierabracci V, et al. Pilot, open, randomized, prospective trial for normothermic machine perfusion evaluation in liver transplantation from older donors. Liver Transpl. 2019;25:436–49.
Yao W, Tai LW, Liu Y, Hei Z, Li H. Oxidative stress and inflammation interaction in ischemia reperfusion injury: role of programmed cell death. Oxid Med Cell Longev. 2019;2019:6780816.
Ravikumar R, Jassem W, Mergental H, Heaton N, Mirza D, Perera MTPR, et al. Liver transplantation after ex vivo normothermic machine preservation: a phase 1 (first‐in‐man) clinical trial. Am J Transplant. 2016;16:1779–87.
Nasralla D, Coussios CC, Mergental H, Akhtar MZ, Butler AJ, Ceresa CDL, et al. A randomized trial of normothermic preservation in liver transplantation. Nature. 2018;557:50–6.
Yetisgin AA, Cetinel S, Zuvin M, Kosar A, Kutlu O. Therapeutic nanoparticles and their targeted delivery applications. Molecules. 2020;25:2193.
Ghinolfi D, Melandro F, Torri F, Martinelli C, Cappello V, Babboni S, et al. Extended criteria grafts and emerging therapeutics strategy in liver transplantation. The unstable balance between damage and repair. Transplant Rev. 2021;35:100639.
Heckert EG, Karakoti AS, Seal S, Self WT. The role of cerium redox state in the SOD mimetic activity of nanoceria. Biomaterials. 2008;29:2705–9.
Pirmohamed T, Dowding JM, Singh S, Wasserman B, Heckert E, Karakoti AS, et al. Nanoceria exhibit redox state‐dependent catalase mimetic activity. Chem Commun (Camb). 2010;46:2736–8.
Dowding JM, Dosani T, Kumar A, Seal S, Self WT. Cerium oxide nanoparticles scavenge nitric oxide radical (˙NO). Chem Commun. 2012;48:4896–8.
Oró D, Yudina T, Fernández‐Varo G, Casals E, Reichenbach V, Casals G, et al. Cerium oxide nanoparticles reduce steatosis, portal hypertension and display anti‐inflammatory properties in rats with liver fibrosis. J Hepatol. 2016;64:691–8.
Carvajal S, Perramón M, Oró D, Casals E, Fernández‐Varo G, Casals G, et al. Cerium oxide nanoparticles display antilipogenic effect in rats with non‐alcoholic fatty liver disease. Sci Rep. 2019;9:12848.
Córdoba‐Jover B, Arce‐Cerezo A, Ribera J, Pauta M, Oró D, Casals G, et al. Cerium oxide nanoparticles improve liver regeneration after acetaminophen‐induced liver injury and partial hepatectomy in rats. J Nanobiotechnology. 2019;17:112.
Ni D, Wei H, Chen W, Bao Q, Rosenkrans ZT, Barnhart TE, et al. Ceria nanoparticles meet hepatic ischemia‐reperfusion injury: the perfect imperfection. Adv Mater. 2019;31:e1902956.
Adebayo OA, Akinloye O, Adaramoye OA. Cerium oxide nanoparticles attenuate oxidative stress and inflammation in the liver of diethylnitrosamine‐treated mice. Biol Trace Elem Res. 2020;193:214–25.
Fernández‐Varo G, Perramón M, Carvajal S, Oró D, Casals E, Boix L, et al. Bespoken nanoceria: an effective treatment in experimental hepatocellular carcinoma. Hepatology. 2020;72:1267–82.
Ghinolfi D, Tincani G, Rreka E, Roffi N, Coletti L, Balzano E, et al. Dual aortic and portal perfusion at procurement prevents ischaemic‐type biliary lesions in liver transplantation when using octogenarian donors: a retrospective cohort study. Transpl Int. 2019;32:193–205.
Watson CJE, Kosmoliaptsis V, Pley C, Randle L, Fear C, Crick K, et al. Observations on the ex situ perfusion of livers for transplantation. Am J Transplant. 2018;18:2005–20.
Detelich DJF, Markmann JF. The dawn of liver perfusion machines. Curr Opin Organ Transplant. 2018;23:151–61.
Xu J, Buchwald JE, Martins PN. Review of current machine perfusion therapeutics for organ preservation. Transplantation. 2020;104:1792–803.
DiRito JR, Hosgood SA, Tietjen GT, Nicholson ML. The future of marginal kidney repair in the context of normothermic machine perfusion. Am J Transplant. 2018;18:2400–8.
Tietjen GT, Hosgood SA, DiRito J, Cui J, Deep D, Song E, et al. Nanoparticle targeting to the endothelium during normothermic machine perfusion of human kidneys. Sci Transl Med. 2017;9:eaam6764.
Weigand MA, Plachky J, Thies JC, Spies‐Martin D, Otto G, Martin E, et al. N‐acetylcysteine attenuates the increase in alpha‐glutathione S‐transferase and circulating ICAM‐1 and VCAM‐1 after reperfusion in humans undergoing liver transplantation. Transplantation. 2001;72:694–8.
Casals E, Zeng M, Parra‐Robert M, Fernández‐Varo G, Morales‐Ruiz M, Jiménez W, et al. Cerium oxide nanoparticles: advances in biodistribution, toxicity, and preclinical exploration. Small. 2020;16:1907322.
Predescu SA, Predescu DN, Malik AB. Molecular determinants of endothelial transcytosis and their role in endothelial permeability. Am J Physiol Lung Cell Mol Physiol. 2007;293:L823–42.
Gillooly AR, Perry J, Martins PN. First report of siRNA uptake (for RNA interference) during ex vivo hypothermic and normothermic liver machine perfusion. Transplantation. 2019;103(3):e56–7.
Suzuki M, Shinohara Y, Ohsaki Y, Fujimoto T. Lipid droplets: size matters. J Electron Microsc (Tokyo). 2011;60(Suppl 1):S101–16.
Henne WM, Reese ML, Goodman JM. The assembly of lipid droplets and their roles in challenged cells. EMBO J. 2018;37:e98947.
Horváth T, Jász DK, Baráth B, Poles MZ, Boros M, Hartmann P. Mitochondrial consequences of organ preservation techniques during liver transplantation. Int J Mol Sci. 2021;22:2816.
Chouchani E, Pell V, James A, Work LM, Saeb‐Parsy K, Frezza C, et al. A unifying mechanism for mitochondrial superoxide production during ischemia‐reperfusion injury. Cell Metab. 2016;23:254–63.
Mailloux RJ. An update on mitochondrial reactive oxygen species production. Antioxidants (Basel). 2020;9:472.
Shami GJ, Cheng D, Verhaegh P, Koek G, Wisse E, Braet F. Three‐dimensional ultrastructure of giant mitochondria in human non‐alcoholic fatty liver disease. Sci Rep. 2021;11:3319.
Cogliati S, Frezza C, Soriano M, Varanita T, Quintana‐Cabrera R, Corrado M, et al. Mitochondrial cristae shape determines respiratory chain supercomplexes assembly and respiratory efficiency. Cell. 2013;155:160–71.
Quintana‐Cabrera R, Mehrotra A, Rigoni G, Soriano ME. Who and how in the regulation of mitochondrial cristae shape and function. Biochem Biophys Res Commun. 2018;500:94–101.
Pezzini I, Marino A, Del Turco S, Nesti C, Doccini S, Cappello V, et al. Cerium oxide nanoparticles: the regenerative redox machine in bioenergetic imbalance. Nanomedicine (Lond). 2017;12:403–16.
Li S, Tan H‐Y, Wang N, Zhang Z‐J, Lao L, Wong C‐W, et al. The role of oxidative stress and antioxidants in liver diseases. Int J Mol Sci. 2015;16:26087–124.
Akhtar MZ, Henderson T, Sutherland A, Vogel T, Friend PJ. Novel approaches to preventing ischemia‐reperfusion injury during liver transplantation. Transplant Proc. 2013;45:2083–92.
Xue Y, Luan Q, Yang D, Yao X, Zhou K. Direct evidence for hydroxyl radical scavenging activity of cerium oxide nanoparticles. J Phys Chem C. 2011;115:4433–8.
Marí M, de Gregorio E, de Dios C, Roca‐Agujetas V, Cucarull B, Tutusaus A, et al. Mitochondrial glutathione: recent insights and role in disease. Antioxidants (Basel). 2020;9(10):909.
Ghinolfi D, Dondossola D, Rreka E, Lonati C, Pezzati D, Cacciatoinsilla A, et al. Sequential use of normothermic regional and ex situ machine perfusion in donation after circulatory death liver transplant. Liver Transpl. 2021;27:385–402.
Yoshidome H, Kato A, Edwards MJ, Lentsch AB. Interleukin‐10 suppresses hepatic ischemia/reperfusion injury in mice: implications of a central role for nuclear factor kappaB. Hepatology. 1999;30:203–8.
Checa J, Aran JM. Reactive oxygen species: drivers of physiological and pathological processes. J Inflamm Res. 2020;13:1057–73.
Barnard A, Moch A, Saab S. Relationship between telomere maintenance and liver disease. Gut Liv. 2019;13:11–5.
Guo ZS, Jin CL, Yao ZJ, Wang YM, Xu BT. Analysis of the mitochondrial 4977 bp deletion in patients with hepatocellular carcinoma. Balkan J Med Genet. 2017;20:81–6.
Del Turco S, Ciofani G, Cappello V, Parlanti P, Gemmi M, Caselli C, et al. Effects of cerium oxide nanoparticles on hemostasis: coagulation, platelets, and vascular endothelial cells. J Biomed Mater Res A. 2019;107:1551–62.
Schlegel A, Muller X, Mueller M, Stepanova A, Kron P, de Rougemont O, et al. Hypothermic oxygenated perfusion protects from mitochondrial injury before liver transplantation. EBioMedicine. 2020;60:103014.
Bral M, Gala‐Lopez B, Thiesen A, Hatami S, Bigam DL, Freed DM, et al. Determination of minimal hemoglobin level necessary for normothermic porcine ex situ liver perfusion. Transplantation. 2018;102:1284–92.