Effect of liraglutide on markers of insulin production in persons with type 2 diabetes treated with multiple daily insulin injections.

Blood Glucose Diabetes Mellitus, Type 2 / drug therapy Glycated Hemoglobin / analysis Humans Hypoglycemic Agents / therapeutic use Insulin / therapeutic use Liraglutide / adverse effects
GLP-1 analogues Insulin secretion Multiple daily insulin injections Type 2 diabetes mellitus

Journal

Journal of diabetes and its complications
ISSN: 1873-460X
Titre abrégé: J Diabetes Complications
Pays: United States
ID NLM: 9204583

Informations de publication

Date de publication:
03 2022
Historique:
received: 17 09 2021
revised: 06 12 2021
accepted: 17 12 2021
pubmed: 2 2 2022
medline: 15 3 2022
entrez: 1 2 2022
Statut: ppublish

Résumé

In this post-hoc analysis of data from a randomised clinical trial, we compared the effect of liraglutide to placebo on markers of insulin secretion in persons with type 2 diabetes treated with multiple daily insulin injections. Liraglutide increased insulin secretion, measured by C-peptide, by 19% after 24 weeks of treatment. CLINICAL TRIAL REGISTRATION: EudraCT 2012-001941-42.

Identifiants

DOI: 10.1016/j.jdiacomp.2021.108110 PMID: 35101325
pubmed: 35101325
pii: S1056-8727(21)00334-2
doi: 10.1016/j.jdiacomp.2021.108110
pii:
doi:

Substances chimiques

Blood Glucose 0
Glycated Hemoglobin A 0
Hypoglycemic Agents 0
Insulin 0
Liraglutide 839I73S42A

Banques de données

EudraCT
['2012-001941-42']

Types de publication

Journal Article Randomized Controlled Trial Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

108110

Informations de copyright

Copyright © 2021. Published by Elsevier Inc.

Auteurs

Klara Westman (K)

Department of Medicine, NU-Hospital Group, Trollhättan, Uddevalla, Sweden; Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden. Electronic address: klara.westman@regionostergotland.se.

Henrik Imberg (H)

Statistiska Konsultgruppen, Gothenburg, Sweden; Department of Mathematical Sciences, Chalmers University of Technology and University of Gothenburg, Gothenburg, Sweden.

Magnus O Wijkman (MO)

Department of Internal Medicine, Department of Health, Medicine and Caring Sciences, Linköping University, Norrköping, Sweden.

Irl B Hirsch (IB)

University of Washington School of Medicine, UW Medicine Diabetes Institute, Seattle, WA 98109, USA.

Jaakko Tuomilehto (J)

Public Health Promotion Unit, Finnish Institute for Health and Welfare, P.O. Box 30, 00271 Helsinki, Finland; Department of Public Health, University of Helsinki, 00014 Helsinki, Finland; Saudi Diabetes Research Group, King Abdulaziz University, 21589 Jeddah, Saudi Arabia.

Sofia Dahlqvist (S)

Department of Medicine, NU-Hospital Group, Trollhättan, Uddevalla, Sweden; Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden.

Marcus Lind (M)

Department of Medicine, NU-Hospital Group, Trollhättan, Uddevalla, Sweden; Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden.

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Classifications MeSH

questionsmedicales.fr › Glucides › Sucres › Oses › Hexose › Glucose › Glycémie › Effect of liraglutide on markers of insulin...
questionsmedicales.fr › Maladies endocriniennes › Diabète › Diabète de type 2 › Effect of liraglutide on markers of insulin...
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Produits terminaux de glycation avancée › Protéines glyquées › Protéine glycosylée sérique › Hémoglobine glycosylée › Effect of liraglutide on markers of insulin...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Effect of liraglutide on markers of insulin...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hypoglycémiants › Effect of liraglutide on markers of insulin...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Hormones peptidiques › Hormones pancréatiques › Insulines › Insuline › Effect of liraglutide on markers of insulin...
questionsmedicales.fr › Hormones gastrointestinales › Peptides glucagon-like › Glucagon-like peptide 1 › Liraglutide › Effect of liraglutide on markers of insulin...