Comparison between genetic and pharmaceutical disruption of Ldlr expression for the development of atherosclerosis.

Animals Atherosclerosis / metabolism Cholesterol Disease Models, Animal Female Hypercholesterolemia / genetics Male Mice Mice, Inbred C57BL Mice, Knockout Pharmaceutical Preparations Receptors, LDL / genetics
animal models antisense oligonucleotides fast-phase liquid chromatography hepatic inflammation hyperlipidemia inflammation liver receptors/lipoprotein serum amyloid A

Journal

Journal of lipid research
ISSN: 1539-7262
Titre abrégé: J Lipid Res
Pays: United States
ID NLM: 0376606

Informations de publication

Date de publication:
03 2022
Historique:
received: 30 08 2021
revised: 22 01 2022
accepted: 24 01 2022
pubmed: 2 2 2022
medline: 5 4 2022
entrez: 1 2 2022
Statut: ppublish

Résumé

Antisense oligonucleotides (ASOs) against Ldl receptor (Ldlr-ASO) represent a promising strategy to promote hypercholesterolemic atherosclerosis in animal models without the need for complex breeding strategies. Here, we sought to characterize and contrast atherosclerosis in mice given Ldlr-ASO with those bearing genetic Ldlr deficiency. To promote atherosclerosis, male and female C57Bl6/J mice were either given weekly injections of Ldlr-ASO (5 mg/kg once per week) or genetically deficient in Ldlr (Ldlr

Identifiants

DOI: 10.1016/j.jlr.2022.100174 PMID: 35101425 PMC: PMC8953673
pubmed: 35101425
pii: S0022-2275(22)00007-4
doi: 10.1016/j.jlr.2022.100174
pmc: PMC8953673
pii:
doi:

Substances chimiques

Pharmaceutical Preparations 0
Receptors, LDL 0
Cholesterol 97C5T2UQ7J

Types de publication

Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

100174

Subventions

Organisme : NHLBI NIH HHS
ID : R35 HL150754
Pays : United States
Organisme : NCCIH NIH HHS
ID : K01 AT007177
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL092969
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL151328
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK017047
Pays : United States

Informations de copyright

Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Conflict of interest The authors declare that they have no conflicts of interest with the contents of this article.

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Auteurs

Diego Gomes (D)

Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA; Diabetes Institute, University of Washington, Seattle, WA, USA.

Shari Wang (S)

Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA; Diabetes Institute, University of Washington, Seattle, WA, USA.

Leela Goodspeed (L)

Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA; Diabetes Institute, University of Washington, Seattle, WA, USA.

Katherine E Turk (KE)

Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA; Diabetes Institute, University of Washington, Seattle, WA, USA.

Tomasz Wietecha (T)

Diabetes Institute, University of Washington, Seattle, WA, USA; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.

Yongjun Liu (Y)

Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, WI, USA.

Karin E Bornfeldt (KE)

Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA; Diabetes Institute, University of Washington, Seattle, WA, USA; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.

Kevin D O'Brien (KD)

Diabetes Institute, University of Washington, Seattle, WA, USA; Division of Cardiology, Department of Medicine, University of Washington, Seattle, WA, USA.

Alan Chait (A)

Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA; Diabetes Institute, University of Washington, Seattle, WA, USA.

Laura J den Hartigh (LJ)

Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA; Diabetes Institute, University of Washington, Seattle, WA, USA. Electronic address: lauradh@u.washington.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Comparison between genetic and pharmaceutical...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Artériopathies oblitérantes › Artériosclérose › Athérosclérose › Comparison between genetic and pharmaceutical...
questionsmedicales.fr › Lipides › Lipides membranaires › Stérols › Cholestérol › Comparison between genetic and pharmaceutical...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Comparison between genetic and pharmaceutical...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Troubles du métabolisme lipidique › Dyslipidémies › Hyperlipidémies › Hypercholestérolémie › Comparison between genetic and pharmaceutical...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Comparison between genetic and pharmaceutical...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Comparison between genetic and pharmaceutical...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Comparison between genetic and pharmaceutical...
questionsmedicales.fr › Préparations pharmaceutiques › Comparison between genetic and pharmaceutical...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux lipoprotéines › Récepteurs aux lipoprotéines LDL › Comparison between genetic and pharmaceutical...