Endosomal TLR3 signaling in stromal osteoblasts induces prostaglandin E

Animals Bone Resorption / genetics Cells, Cultured Dinoprostone / biosynthesis Endosomes / metabolism Indomethacin / pharmacology Mice Osteoblasts / metabolism Osteoclasts / metabolism Prostaglandins E / adverse effects RANK Ligand / metabolism RNA, Messenger / metabolism Toll-Like Receptor 3 / genetics
Toll-like receptor bone resorption osteoblast osteoclast prostaglandin

Journal

The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R

Informations de publication

Date de publication:
03 2022
Historique:
received: 08 12 2021
accepted: 05 01 2022
pubmed: 2 2 2022
medline: 16 4 2022
entrez: 1 2 2022
Statut: ppublish

Résumé

Toll-like receptors (TLRs) are pattern recognition receptors that play a critical role in innate immune diseases. TLR3, which is localized in the endosomal compartments of hematopoietic immune cells, is able to recognize double-stranded RNA (dsRNA) derived from viruses and bacteria and thereby induce innate immune responses. Inflammatory periodontal bone resorption is caused by bacterial infections, which initially is regulated by innate immunity; however, the roles of TLR3 signaling in bone resorption are still not known. We examined the roles of TLR3 signaling in bone resorption using poly(I:C), a synthetic dsRNA analog. In cocultures of mouse bone marrow cells and stromal osteoblasts, poly(I:C) clearly induced osteoclast differentiation. In osteoblasts, poly(I:C) increased PGE

Identifiants

DOI: 10.1016/j.jbc.2022.101603 PMID: 35101442 PMC: PMC8892075
pubmed: 35101442
pii: S0021-9258(22)00043-6
doi: 10.1016/j.jbc.2022.101603
pmc: PMC8892075
pii:
doi:

Substances chimiques

Prostaglandins E 0
RANK Ligand 0
RNA, Messenger 0
TLR3 protein, mouse 0
Toll-Like Receptor 3 0
Dinoprostone K7Q1JQR04M
Indomethacin XXE1CET956

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

101603

Informations de copyright

Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Conflict of interest The authors declare that they have no conflicts of interest with the contents of this article.

Auteurs

Tsukasa Tominari (T)

Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, Koganei, Tokyo, Japan.

Miyuki Akita (M)

Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, Koganei, Tokyo, Japan.

Chiho Matsumoto (C)

Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, Koganei, Tokyo, Japan.

Michiko Hirata (M)

Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, Koganei, Tokyo, Japan.

Shosei Yoshinouchi (S)

Cooperative Major of Advanced Health Science, Tokyo University of Agriculture and Technology, Koganei, Tokyo, Japan.

Yuki Tanaka (Y)

Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, Koganei, Tokyo, Japan.

Kento Karouji (K)

Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, Koganei, Tokyo, Japan.

Yoshifumi Itoh (Y)

Institute of Global Innovation Research, Tokyo University of Agriculture and Technology, Koganei, Tokyo, Japan; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK.

Takayuki Maruyama (T)

Minase Research Institutes, Ono Pharmaceutical Co Ltd, Osaka, Japan.

Chisato Miyaura (C)

Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, Koganei, Tokyo, Japan; Cooperative Major of Advanced Health Science, Tokyo University of Agriculture and Technology, Koganei, Tokyo, Japan; Institute of Global Innovation Research, Tokyo University of Agriculture and Technology, Koganei, Tokyo, Japan.

Yukihiro Numabe (Y)

Department of Periodontology, School of Dentistry, The Nippon Dental University, Chiyoda-ku, Tokyo, Japan.

Masaki Inada (M)

Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, Koganei, Tokyo, Japan; Cooperative Major of Advanced Health Science, Tokyo University of Agriculture and Technology, Koganei, Tokyo, Japan; Institute of Global Innovation Research, Tokyo University of Agriculture and Technology, Koganei, Tokyo, Japan. Electronic address: m-inada@cc.tuat.ac.jp.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Endosomal TLR3 signaling in stromal...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Résorption osseuse › Endosomal TLR3 signaling in stromal...
questionsmedicales.fr › Cellules › Cellules cultivées › Endosomal TLR3 signaling in stromal...
questionsmedicales.fr › Facteurs biologiques › Médiateurs de l'inflammation › Autacoïdes › Éicosanoïdes › Prostaglandines › Prostaglandines E › Dinoprostone › Endosomal TLR3 signaling in stromal...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Vésicules cytoplasmiques › Vésicules de transport › Endosomes › Endosomal TLR3 signaling in stromal...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Indoles › Indométacine › Endosomal TLR3 signaling in stromal...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Endosomal TLR3 signaling in stromal...
questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Ostéoblastes › Endosomal TLR3 signaling in stromal...
questionsmedicales.fr › Cellules › Cellules myéloïdes › Ostéoclastes › Endosomal TLR3 signaling in stromal...
questionsmedicales.fr › Facteurs biologiques › Médiateurs de l'inflammation › Autacoïdes › Éicosanoïdes › Prostaglandines › Prostaglandines E › Endosomal TLR3 signaling in stromal...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Facteurs de nécrose tumorale › Ligand de RANK › Endosomal TLR3 signaling in stromal...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN messager › Endosomal TLR3 signaling in stromal...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs de reconnaissance de motifs moléculaires › Récepteurs de type Toll › Récepteur de type Toll-3 › Endosomal TLR3 signaling in stromal...