Pathogenomic analyses of Shigella isolates inform factors limiting shigellosis prevention and control across LMICs.

Child Child, Preschool Ciprofloxacin / pharmacology Developing Countries / statistics & numerical data Drug Resistance, Bacterial Dysentery, Bacillary / drug therapy Evolution, Molecular Genome, Bacterial Global Health Humans Shigella / classification Shigella sonnei / pathogenicity Whole Genome Sequencing

Journal

Nature microbiology
ISSN: 2058-5276
Titre abrégé: Nat Microbiol
Pays: England
ID NLM: 101674869

Informations de publication

Date de publication:
02 2022
Historique:
received: 14 06 2021
accepted: 17 12 2021
pubmed: 2 2 2022
medline: 23 2 2022
entrez: 1 2 2022
Statut: ppublish

Résumé

Shigella spp. are the leading bacterial cause of severe childhood diarrhoea in low- and middle-income countries (LMICs), are increasingly antimicrobial resistant and have no widely available licenced vaccine. We performed genomic analyses of 1,246 systematically collected shigellae sampled from seven countries in sub-Saharan Africa and South Asia as part of the Global Enteric Multicenter Study (GEMS) between 2007 and 2011, to inform control and identify factors that could limit the effectiveness of current approaches. Through contemporaneous comparison among major subgroups, we found that S. sonnei contributes ≥6-fold more disease than other Shigella species relative to its genomic diversity, and highlight existing diversity and adaptative capacity among S. flexneri that may generate vaccine escape variants in <6 months. Furthermore, we show convergent evolution of resistance against ciprofloxacin, the current WHO-recommended antimicrobial for the treatment of shigellosis, among Shigella isolates. This demonstrates the urgent need to integrate existing genomic diversity into vaccine and treatment plans for Shigella, providing a framework for the focused application of comparative genomics to guide vaccine development, and the optimization of control and prevention strategies for other pathogens relevant to public health policy considerations.

Identifiants

DOI: 10.1038/s41564-021-01054-z PMID: 35102306 PMC: PMC8813619
pubmed: 35102306
doi: 10.1038/s41564-021-01054-z
pii: 10.1038/s41564-021-01054-z
pmc: PMC8813619
mid: EMS140615
doi:

Substances chimiques

Ciprofloxacin 5E8K9I0O4U

Banques de données

figshare
['10.6084/m9.figshare.14743833']

Types de publication

Journal Article Multicenter Study Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

251-261

Subventions

Organisme : Wellcome Trust
ID : 106690
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/CCG1720/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R020787/1
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : U19 AI110820
Pays : United States
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 106690/A/14/Z
Pays : United Kingdom

Informations de copyright

© 2022. The Author(s).

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Auteurs

Rebecca J Bengtsson (RJ)

Clinical Infection, Microbiology and Immunity, Institute of Infection, Veterinary and Ecological Sciences, The University of Liverpool, Liverpool, UK.

Adam J Simpkin (AJ)

Biochemistry and Systems Biology, Institute of Systems, Molecular and Systems Biology, The University of Liverpool, Liverpool, UK.

Caisey V Pulford (CV)

Clinical Infection, Microbiology and Immunity, Institute of Infection, Veterinary and Ecological Sciences, The University of Liverpool, Liverpool, UK.
Gastrointestinal Infections and Food Safety (One Health), United Kingdom Health Security Agency, London, UK.

Ross Low (R)

Earlham Institute, Norwich Research Park, Norwich, UK.

David A Rasko (DA)

Department of Microbiology and Immunology, Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
ORCID: 0000-0002-7337-7154

Daniel J Rigden (DJ)

Biochemistry and Systems Biology, Institute of Systems, Molecular and Systems Biology, The University of Liverpool, Liverpool, UK.

Neil Hall (N)

Earlham Institute, Norwich Research Park, Norwich, UK.
School of Biological Sciences, University of East Anglia, Norwich, UK.

Eileen M Barry (EM)

Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, USA.
ORCID: 0000-0002-5326-0047

Sharon M Tennant (SM)

Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, USA.

Kate S Baker (KS)

Clinical Infection, Microbiology and Immunity, Institute of Infection, Veterinary and Ecological Sciences, The University of Liverpool, Liverpool, UK. kbaker@liverpool.ac.uk.
ORCID: 0000-0001-5850-1949

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Pathogenomic analyses of Shigella isolates...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Enfant d'âge préscolaire › Pathogenomic analyses of Shigella isolates...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Quinoléines › Quinolinone › Fluoroquinolones › Ciprofloxacine › Pathogenomic analyses of Shigella isolates...
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