Pegylated arginine deiminase drives arginine turnover and systemic autophagy to dictate energy metabolism.
Animals
Arginine
/ metabolism
Autophagy
Beclin-1
/ metabolism
Dependovirus
/ metabolism
Diabetes Mellitus, Experimental
/ genetics
Diet, Western
Dyslipidemias
/ pathology
Energy Metabolism
Fatty Liver
/ pathology
Fibroblast Growth Factors
/ metabolism
Glucose
/ metabolism
Hepatocytes
/ metabolism
Homeostasis
Hydrolases
/ chemistry
Insulin Resistance
Liver
/ metabolism
Male
Mice
Mice, Inbred C57BL
Polyethylene Glycols
/ chemistry
Thermogenesis
ADI-PEG 20
Beclin-1
FGF21
GLUT
arcA
arginase
arginine
arginine deiminase
autophagy
caloric restriction
diabetes
energy metabolism
fasting
glucose transport
insulin resistance
liver
non-alcoholic fatty liver disease
obesity
thermogenesis
Journal
Cell reports. Medicine
ISSN: 2666-3791
Titre abrégé: Cell Rep Med
Pays: United States
ID NLM: 101766894
Informations de publication
Date de publication:
18 01 2022
18 01 2022
Historique:
received:
09
07
2021
revised:
16
11
2021
accepted:
16
12
2021
entrez:
2
2
2022
pubmed:
3
2
2022
medline:
5
3
2022
Statut:
epublish
Résumé
Obesity is a multi-systemic disorder of energy balance. Despite intense investigation, the determinants of energy homeostasis remain incompletely understood, and efficacious treatments against obesity and its complications are lacking. Here, we demonstrate that conferred arginine iminohydrolysis by the bacterial virulence factor and arginine deiminase,
Identifiants
pubmed: 35106510
doi: 10.1016/j.xcrm.2021.100498
pii: S2666-3791(21)00375-X
pmc: PMC8784773
doi:
Substances chimiques
Beclin-1
0
fibroblast growth factor 21
0
Polyethylene Glycols
3WJQ0SDW1A
Fibroblast Growth Factors
62031-54-3
Arginine
94ZLA3W45F
Hydrolases
EC 3.-
ADI PEG20
EC 3.5.3.6
arginine deiminase
EC 3.5.3.6
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
100498Subventions
Organisme : NCI NIH HHS
ID : R01 CA227115
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL147968
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002345
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK126622
Pays : United States
Organisme : NIDDK NIH HHS
ID : F31 DK131875
Pays : United States
Informations de copyright
© 2021 The Author(s).
Déclaration de conflit d'intérêts
Part of this study was funded by a sponsored research agreement awarded by Polaris Pharmaceuticals (to B.J.D.). B.J.D. is the lead inventor on US Patent Application #17/050,318. Relevant US Patent Publication #US2021/0077598, toward which the presented data are material. J.S.B. is an employee of Polaris Pharmaceuticals, Inc.
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