Development of a ligand for in vivo imaging of mutant huntingtin in Huntington's disease.

Animals Corpus Striatum / diagnostic imaging Disease Models, Animal Huntingtin Protein / genetics Huntington Disease / diagnostic imaging Ligands Neurodegenerative Diseases / pathology

Journal

Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086

Informations de publication

Date de publication:
02 02 2022
Historique:
entrez: 2 2 2022
pubmed: 3 2 2022
medline: 27 4 2022
Statut: ppublish

Résumé

Huntington's disease (HD) is a dominantly inherited neurodegenerative disorder caused by a CAG trinucleotide expansion in the huntingtin (

Identifiants

DOI: 10.1126/scitranslmed.abm3682 PMID: 35108063
pubmed: 35108063
doi: 10.1126/scitranslmed.abm3682
doi:

Substances chimiques

Huntingtin Protein 0
Ligands 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

eabm3682

Commentaires et corrections

Type : CommentIn

Auteurs

Daniele Bertoglio (D)

Molecular Imaging Center Antwerp (MICA), University of Antwerp, Wilrijk 2610, Belgium.
ORCID: 0000-0003-4205-5432

Jonathan Bard (J)

CHDI Management/CHDI Foundation, Los Angeles, CA 90045, USA.
ORCID: 0000-0002-5097-1361

Manuela Hessmann (M)

Evotec SE, Hamburg 22419, Germany.

Longbin Liu (L)

CHDI Management/CHDI Foundation, Los Angeles, CA 90045, USA.
ORCID: 0000-0003-3995-0196

Annette Gärtner (A)

Evotec SE, Hamburg 22419, Germany.

Stef De Lombaerde (S)

Molecular Imaging Center Antwerp (MICA), University of Antwerp, Wilrijk 2610, Belgium.
Department of Nuclear Medicine, Antwerp University Hospital, Edegem 2650, Belgium.
ORCID: 0000-0002-5307-3575

Britta Huscher (B)

Evotec SE, Hamburg 22419, Germany.

Franziska Zajicek (F)

Molecular Imaging Center Antwerp (MICA), University of Antwerp, Wilrijk 2610, Belgium.

Alan Miranda (A)

Molecular Imaging Center Antwerp (MICA), University of Antwerp, Wilrijk 2610, Belgium.
ORCID: 0000-0002-5381-015X

Finn Peters (F)

Evotec SE, Hamburg 22419, Germany.
ORCID: 0000-0002-3062-9825

Frank Herrmann (F)

Evotec SE, Hamburg 22419, Germany.

Sabine Schaertl (S)

Evotec SE, Hamburg 22419, Germany.
ORCID: 0000-0001-5495-4801

Tamara Vasilkovska (T)

Bio-Imaging Lab, University of Antwerp, Wilrijk 2610, Belgium.
ORCID: 0000-0001-7611-3966

Christopher J Brown (CJ)

Evotec Ltd., Abingdon OX14 4RZ, UK.

Peter D Johnson (PD)

Evotec Ltd., Abingdon OX14 4RZ, UK.
ORCID: 0000-0002-5968-6233

Michael E Prime (ME)

Evotec Ltd., Abingdon OX14 4RZ, UK.
ORCID: 0000-0002-5744-6885

Matthew R Mills (MR)

Evotec Ltd., Abingdon OX14 4RZ, UK.

Annemie Van der Linden (A)

Bio-Imaging Lab, University of Antwerp, Wilrijk 2610, Belgium.
ORCID: 0000-0003-2941-6520

Ladislav Mrzljak (L)

CHDI Management/CHDI Foundation, Los Angeles, CA 90045, USA.
ORCID: 0000-0002-5777-1354

Vinod Khetarpal (V)

CHDI Management/CHDI Foundation, Los Angeles, CA 90045, USA.
ORCID: 0000-0002-2175-5117

Yuchuan Wang (Y)

CHDI Management/CHDI Foundation, Los Angeles, CA 90045, USA.

Deanna M Marchionini (DM)

CHDI Management/CHDI Foundation, Los Angeles, CA 90045, USA.

Mette Skinbjerg (M)

CHDI Management/CHDI Foundation, Los Angeles, CA 90045, USA.

Jeroen Verhaeghe (J)

Molecular Imaging Center Antwerp (MICA), University of Antwerp, Wilrijk 2610, Belgium.
ORCID: 0000-0002-4493-1902

Celia Dominguez (C)

CHDI Management/CHDI Foundation, Los Angeles, CA 90045, USA.
ORCID: 0000-0001-6862-1645

Steven Staelens (S)

Molecular Imaging Center Antwerp (MICA), University of Antwerp, Wilrijk 2610, Belgium.
ORCID: 0000-0003-3376-0519

Ignacio Munoz-Sanjuan (I)

CHDI Management/CHDI Foundation, Los Angeles, CA 90045, USA.
ORCID: 0000-0003-0353-3577

Articles similaires

Evaluating the efficacy of telesurgery with dual console SSI Mantra Surgical Robotic System: experiment on animal model and clinical trials.

Sudhir Prem Srivastava, Vishwajyoti Pascual Srivastava, Avinesh Singh et al.
1.00
Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell

FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.

Minle Li, Xuan Chen, Pengfei Qu et al.
1.00
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Use of organic material provided by an automatic enrichment device by weaner pigs and its influence on tail lesions.

Philipp Heseker, Jeanette Probst, Stefanie Ammer et al.
1.00
Animals Tail Swine Behavior, Animal Animal Husbandry

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Development of a ligand for in vivo imaging of...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Noyaux gris centraux › Corps strié › Development of a ligand for in vivo imaging of...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Development of a ligand for in vivo imaging of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéine huntingtine › Development of a ligand for in vivo imaging of...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie de Huntington › Development of a ligand for in vivo imaging of...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Ligands › Development of a ligand for in vivo imaging of...
questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › Development of a ligand for in vivo imaging of...