Mice expressing fluorescent PAR

Animals Arrestins / metabolism Cell Membrane / metabolism Colon / metabolism Endocytosis / physiology Endosomes / metabolism Female Fluorescent Dyes / metabolism Ganglia, Spinal / metabolism Humans Inflammation / metabolism Mice Mice, Inbred C57BL Nociception / physiology Pain / metabolism Receptor, PAR-2 / metabolism Signal Transduction / physiology
endocytosis inflammation proteases receptors signaling

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
08 02 2022
Historique:
accepted: 22 12 2021
entrez: 3 2 2022
pubmed: 4 2 2022
medline: 26 2 2022
Statut: ppublish

Résumé

G protein-coupled receptors (GPCRs) regulate many pathophysiological processes and are major therapeutic targets. The impact of disease on the subcellular distribution and function of GPCRs is poorly understood. We investigated trafficking and signaling of protease-activated receptor 2 (PAR

Identifiants

DOI: 10.1073/pnas.2112059119 PMID: 35110404 PMC: PMC8833192
pubmed: 35110404
pii: 2112059119
doi: 10.1073/pnas.2112059119
pmc: PMC8833192
pii:
doi:

Substances chimiques

Arrestins 0
F2rl1 protein, mouse 0
Fluorescent Dyes 0
Receptor, PAR-2 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIAID NIH HHS
ID : R21 AI137663
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK118971
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS102722
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE029951
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE026806
Pays : United States

Commentaires et corrections

Type : ErratumIn

Informations de copyright

Copyright © 2022 the Author(s). Published by PNAS.

Déclaration de conflit d'intérêts

Competing interest statement: N.W.B. is a founding scientist of Endosome Therapeutics, Inc. Research in the laboratories of N.W.B., N.A.V., and D.P.P. is funded in part by Takeda Pharmaceuticals International.

Références

J Biol Chem. 2016 May 20;291(21):11285-99
pubmed: 27030010
Pharmacol Rev. 2017 Jul;69(3):256-297
pubmed: 28626043
J Biol Chem. 2005 Apr 22;280(16):16076-87
pubmed: 15708858
Proc Natl Acad Sci U S A. 2000 May 9;97(10):5255-60
pubmed: 10805786
Neurogastroenterol Motil. 2015 Nov;27(11):1675-80
pubmed: 26303377
Nat Commun. 2019 Mar 13;10(1):1198
pubmed: 30867416
J Physiol. 2004 Aug 1;558(Pt 3):913-25
pubmed: 15194744
Nat Med. 2000 Feb;6(2):151-8
pubmed: 10655102
Nat Commun. 2017 Sep 5;8(1):443
pubmed: 28874659
J Biol Chem. 2004 Apr 2;279(14):13532-9
pubmed: 14726524
J Cell Biol. 2000 Mar 20;148(6):1267-81
pubmed: 10725339
Gastroenterology. 2007 Jun;132(7):2422-37
pubmed: 17570216
J Biol Chem. 2005 Sep 9;280(36):31936-48
pubmed: 16027150
J Clin Invest. 1997 Sep 15;100(6):1383-93
pubmed: 9294103
ACS Chem Biol. 2016 Feb 19;11(2):400-8
pubmed: 26569370
Sci Rep. 2018 May 18;8(1):7834
pubmed: 29777136
Nat Nanotechnol. 2019 Dec;14(12):1150-1159
pubmed: 31686009
Trends Pharmacol Sci. 2018 Oct;39(10):879-891
pubmed: 30180973
Proc Natl Acad Sci U S A. 2005 Jun 7;102(23):8363-8
pubmed: 15919826
Proc Natl Acad Sci U S A. 2020 Jun 30;117(26):15281-15292
pubmed: 32546520
J Biol Chem. 2019 Jul 5;294(27):10649-10662
pubmed: 31142616
Gastroenterology. 2011 Nov;141(5):1864-74.e1-3
pubmed: 21802389
Am J Pathol. 2002 Nov;161(5):1903-15
pubmed: 12414536
Gastroenterology. 2011 Sep;141(3):982-991.e18
pubmed: 21699782
J Neurosci. 2021 Jan 6;41(1):193-210
pubmed: 33172978
JCI Insight. 2020 Jun 4;5(11):
pubmed: 32352932
Cell. 2016 Aug 11;166(4):907-919
pubmed: 27499021
Neuron. 2018 Jun 6;98(5):963-976.e5
pubmed: 29754753
Proc Natl Acad Sci U S A. 2018 Jul 31;115(31):E7438-E7447
pubmed: 30012612
J Biol Chem. 2014 Jul 18;289(29):20283-94
pubmed: 24898255
Nat Struct Mol Biol. 2019 Dec;26(12):1123-1131
pubmed: 31740855
J Biol Chem. 2006 Oct 27;281(43):32095-112
pubmed: 16885167
Sci Rep. 2018 Jan 12;8(1):667
pubmed: 29330459
J Biol Chem. 2014 Sep 26;289(39):27215-27234
pubmed: 25118282
Biochem J. 1996 Mar 15;314 ( Pt 3):1009-16
pubmed: 8615752
J Biol Chem. 2015 May 29;290(22):13875-87
pubmed: 25878251
Sci Transl Med. 2017 May 31;9(392):
pubmed: 28566424
Gastroenterology. 2019 May;156(6):1600-1616
pubmed: 30771352
Nat Med. 2001 Jul;7(7):821-6
pubmed: 11433347
Proc Natl Acad Sci U S A. 1997 Aug 5;94(16):8884-9
pubmed: 9238072
J Immunol. 2003 Apr 15;170(8):4296-300
pubmed: 12682265
Sci Rep. 2019 Sep 16;9(1):13295
pubmed: 31527638
Proc Natl Acad Sci U S A. 2006 Jun 20;103(25):9691-6
pubmed: 16766653
Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):12309-12314
pubmed: 29087309
Physiol Rev. 2004 Apr;84(2):579-621
pubmed: 15044683
Nature. 2013 Mar 28;495(7442):534-8
pubmed: 23515162

Auteurs

Rocco Latorre (R)

Department of Molecular Pathobiology, Neuroscience Institute, New York University, New York, NY 10010.
Department of Neuroscience and Physiology, Neuroscience Institute, New York University, New York, NY 10010.
ORCID: 0000-0003-2737-8233

Alan Hegron (A)

Department of Molecular Pathobiology, Neuroscience Institute, New York University, New York, NY 10010.
Department of Neuroscience and Physiology, Neuroscience Institute, New York University, New York, NY 10010.

Chloe J Peach (CJ)

Department of Molecular Pathobiology, Neuroscience Institute, New York University, New York, NY 10010.
Department of Neuroscience and Physiology, Neuroscience Institute, New York University, New York, NY 10010.

Shavonne Teng (S)

Department of Molecular Pathobiology, Neuroscience Institute, New York University, New York, NY 10010.
Department of Neuroscience and Physiology, Neuroscience Institute, New York University, New York, NY 10010.
ORCID: 0000-0002-1045-0879

Raquel Tonello (R)

Department of Molecular Pathobiology, Neuroscience Institute, New York University, New York, NY 10010.
Department of Neuroscience and Physiology, Neuroscience Institute, New York University, New York, NY 10010.
ORCID: 0000-0002-2175-9804

Jeffri S Retamal (JS)

Department of Molecular Pathobiology, Neuroscience Institute, New York University, New York, NY 10010.
Department of Neuroscience and Physiology, Neuroscience Institute, New York University, New York, NY 10010.
Bluestone Center for Clinical Research, New York University College of Dentistry, New York, NY 10010.
ORCID: 0000-0003-4984-4530

Rafael Klein-Cloud (R)

Department of Molecular Pathobiology, Neuroscience Institute, New York University, New York, NY 10010.
Department of Neuroscience and Physiology, Neuroscience Institute, New York University, New York, NY 10010.
ORCID: 0000-0003-0347-3543

Diana Bok (D)

Department of Molecular Pathobiology, Neuroscience Institute, New York University, New York, NY 10010.
Department of Neuroscience and Physiology, Neuroscience Institute, New York University, New York, NY 10010.
Bluestone Center for Clinical Research, New York University College of Dentistry, New York, NY 10010.

Dane D Jensen (DD)

Department of Molecular Pathobiology, Neuroscience Institute, New York University, New York, NY 10010.
Department of Neuroscience and Physiology, Neuroscience Institute, New York University, New York, NY 10010.
Bluestone Center for Clinical Research, New York University College of Dentistry, New York, NY 10010.
ORCID: 0000-0001-6540-2375

Lena Gottesman-Katz (L)

Department of Molecular Pathobiology, Neuroscience Institute, New York University, New York, NY 10010.
Department of Neuroscience and Physiology, Neuroscience Institute, New York University, New York, NY 10010.

Jeanette Rientjes (J)

Gene Modification Platform, Monash University, Clayton, VIC 3168, Australia.

Nicholas A Veldhuis (NA)

Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.
ORCID: 0000-0002-8902-9365

Daniel P Poole (DP)

Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.
ORCID: 0000-0002-6168-8422

Brian L Schmidt (BL)

Department of Molecular Pathobiology, Neuroscience Institute, New York University, New York, NY 10010.
Department of Neuroscience and Physiology, Neuroscience Institute, New York University, New York, NY 10010.
Bluestone Center for Clinical Research, New York University College of Dentistry, New York, NY 10010.

Charalabos H Pothoulakis (CH)

Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.

Carl Rankin (C)

Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.
ORCID: 0000-0002-8480-289X

Ying Xie (Y)

Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.

Hon Wai Koon (HW)

Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.
ORCID: 0000-0003-0618-0869

Nigel W Bunnett (NW)

Department of Molecular Pathobiology, Neuroscience Institute, New York University, New York, NY 10010; nwb2@nyu.edu.
Department of Neuroscience and Physiology, Neuroscience Institute, New York University, New York, NY 10010.
ORCID: 0000-0003-3367-0644

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Mice expressing fluorescent PAR
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Arrestines › Mice expressing fluorescent PAR
questionsmedicales.fr › Cellules › Structures cellulaires › Membrane cellulaire › Mice expressing fluorescent PAR
questionsmedicales.fr › Système digestif › Tube digestif › Tube digestif inférieur › Gros intestin › Côlon › Mice expressing fluorescent PAR
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Endocytose › Mice expressing fluorescent PAR
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Vésicules cytoplasmiques › Vésicules de transport › Endosomes › Mice expressing fluorescent PAR
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Indicateurs et réactifs › Luminescents › Colorants fluorescents › Mice expressing fluorescent PAR
questionsmedicales.fr › Système nerveux › Système nerveux périphérique › Nerfs périphériques › Nerfs spinaux › Racines des nerfs spinaux › Ganglions sensitifs des nerfs spinaux › Mice expressing fluorescent PAR
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Mice expressing fluorescent PAR
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Mice expressing fluorescent PAR
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Mice expressing fluorescent PAR
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Mice expressing fluorescent PAR
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Perception › Perception de la douleur › Nociception › Mice expressing fluorescent PAR
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Sensation › Douleur › Mice expressing fluorescent PAR
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs activés par la protéinase › Récepteur de type PAR-2 › Mice expressing fluorescent PAR
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Mice expressing fluorescent PAR