Hair androgen concentrations and depressive disorders in adolescents from the general population.
Dehydroepiandrosterone
Depressive symptoms
Epidemiology
Hair testosterone
Major depressive disorder
Testosterone
Journal
European child & adolescent psychiatry
ISSN: 1435-165X
Titre abrégé: Eur Child Adolesc Psychiatry
Pays: Germany
ID NLM: 9212296
Informations de publication
Date de publication:
Aug 2023
Aug 2023
Historique:
received:
30
07
2021
accepted:
12
12
2021
medline:
10
7
2023
pubmed:
4
2
2022
entrez:
3
2
2022
Statut:
ppublish
Résumé
Although the link between androgens and depression is well established in adults, the effects of cofactors on this association are less clearly understood, particularly in youth. Epidemiological cohort study of adolescents in Dresden, Germany. Analyses comprised data of 985 individuals assessed at baseline and of 512 individuals at 1-year follow-up. We investigated multivariable regression models for cross-sectional and longitudinal associations of hair testosterone, dehydroepiandrosterone (DHEA), and their cortisol ratios with 12-month diagnoses of major depressive disorder (MDD) and MDD without any anxiety disorder assessed with standardized diagnostic interview (DIA-X-5), and with dimensional depression scores (PHQ-9, PROMIS), separately for males and females. The potential moderating effect of social support was determined. Cross-sectional analyses yielded inverse associations of testosterone and DHEA with MDD and MDD without any anxiety disorders in males. In cross-sectional and longitudinal analyses, baseline ratio cortisol/DHEA was significantly, inversely associated to PROMIS-depression in males. Only cross-sectional associations for ratio cortisol/DHEA and PROMIS-depression remained significant after Bonferroni-Holm correction. No robust associations were observed in female participants. Social support exerted no consistent moderating effect on the investigated association. The present observational cohort study showed no consistent association of hair androgen concentrations with depressive disorders in adolescents. However, findings provide some support for the association between the cortisol/DHEA ratio and depression in males. Longitudinal research designs in large samples are needed to understand the interplay between androgens, depression, and developmental and social factors in youth.
Identifiants
pubmed: 35112167
doi: 10.1007/s00787-021-01929-w
pii: 10.1007/s00787-021-01929-w
pmc: PMC10326161
doi:
Substances chimiques
Androgens
0
Dehydroepiandrosterone
459AG36T1B
Hydrocortisone
WI4X0X7BPJ
Testosterone
3XMK78S47O
Types de publication
Observational Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1375-1389Subventions
Organisme : bundesministerium für bildung und forschung
ID : 01ER1303
Organisme : bundesministerium für bildung und forschung
ID : 01ER1703
Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2022. The Author(s).
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