Mapping dopaminergic projections in the human brain with resting-state fMRI.
Adult
Aged
Aged, 80 and over
Biomarkers
/ analysis
Brain
/ diagnostic imaging
Cohort Studies
Corpus Striatum
/ diagnostic imaging
Dopamine
/ metabolism
Dopamine Plasma Membrane Transport Proteins
/ physiology
Female
Humans
Levodopa
/ therapeutic use
Magnetic Resonance Imaging
/ methods
Male
Middle Aged
Neural Pathways
/ physiopathology
Parkinson Disease
/ diagnostic imaging
Parkinson's disease
connectopic mapping
dopaminergic projections
human
neuroscience
resting-state fMRI
striatum
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
03 02 2022
03 02 2022
Historique:
received:
01
07
2021
accepted:
26
01
2022
pubmed:
4
2
2022
medline:
3
3
2022
entrez:
3
2
2022
Statut:
epublish
Résumé
The striatum receives dense dopaminergic projections, making it a key region of the dopaminergic system. Its dysfunction has been implicated in various conditions including Parkinson's disease (PD) and substance use disorder. However, the investigation of dopamine-specific functioning in humans is problematic as current MRI approaches are unable to differentiate between dopaminergic and other projections. Here, we demonstrate that 'connectopic mapping' - a novel approach for characterizing fine-grained, overlapping modes of functional connectivity - can be used to map dopaminergic projections in striatum. We applied connectopic mapping to resting-state functional MRI data of the Human Connectome Project (population cohort; N = 839) and selected the second-order striatal connectivity mode for further analyses. We first validated its specificity to dopaminergic projections by demonstrating a high spatial correlation (
Identifiants
pubmed: 35113016
doi: 10.7554/eLife.71846
pii: 71846
pmc: PMC8843090
doi:
pii:
Substances chimiques
Biomarkers
0
Dopamine Plasma Membrane Transport Proteins
0
Levodopa
46627O600J
Dopamine
VTD58H1Z2X
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIMH NIH HHS
ID : U54 MH091657
Pays : United States
Informations de copyright
© 2022, Oldehinkel et al.
Déclaration de conflit d'intérêts
MO, AL, MF, IH, JB, BB, AM, RH, KH No competing interests declared, CB C.F.B. is director and shareholder in SBGneuro Ltd
Références
Neuropsychopharmacology. 2010 Jan;35(1):4-26
pubmed: 19812543
Neurodegener Dis. 2008;5(3-4):114-7
pubmed: 18322366
Nat Rev Neurosci. 2004 Jun;5(6):483-94
pubmed: 15152198
Neuroscience. 2014 Dec 12;282:248-57
pubmed: 25445194
Neuroimage. 2002 Oct;17(2):825-41
pubmed: 12377157
J Neurosci. 2005 Mar 16;25(11):2771-80
pubmed: 15772337
Psychiatry Res Neuroimaging. 2020 Nov 30;305:111187
pubmed: 32947183
Prog Neurobiol. 2011 Dec;95(4):629-35
pubmed: 21930184
Neuroimage. 2014 Apr 15;90:449-68
pubmed: 24389422
Multivariate Behav Res. 1966 Apr 1;1(2):245-76
pubmed: 26828106
Nat Rev Neurosci. 2015 May;16(5):305-12
pubmed: 25873042
N Engl J Med. 2008 Dec 4;359(23):2468-76
pubmed: 19052127
Prog Neuropsychopharmacol Biol Psychiatry. 2008 Jan 1;32(1):274-9
pubmed: 17900774
Curr Top Behav Neurosci. 2015;24:55-98
pubmed: 25638334
Neuroimage. 2020 Dec;223:117322
pubmed: 32882388
Nat Hum Behav. 2017 Aug;1(8):0146
pubmed: 28804783
Brain. 2019 Oct 1;142(10):3144-3157
pubmed: 31509182
Mol Imaging Biol. 2019 Apr;21(2):339-347
pubmed: 29987621
Nat Neurosci. 2020 Nov;23(11):1421-1432
pubmed: 32989295
Brain. 2013 Aug;136(Pt 8):2419-31
pubmed: 23884810
Mov Disord. 2014 Dec;29(14):1767-73
pubmed: 25048738
Brain. 2012 Sep;135(Pt 9):2798-808
pubmed: 22961551
J Chiropr Med. 2016 Jun;15(2):155-63
pubmed: 27330520
Synapse. 2004 Nov;54(2):65-71
pubmed: 15352131
Mol Psychiatry. 2007 Apr;12(4):331-59
pubmed: 17389902
Neuroimage. 2020 Oct 15;220:117061
pubmed: 32574808
Neuroimage. 2020 Nov 15;222:117257
pubmed: 32822812
Neuroimage. 2018 Apr 15;170:83-94
pubmed: 28666880
Hum Brain Mapp. 2021 Feb 15;42(3):555-566
pubmed: 33079453
N Engl J Med. 1988 Apr 7;318(14):876-80
pubmed: 3352672
Neuroimage. 2020 Sep;218:116960
pubmed: 32454205
Med Image Anal. 2001 Jun;5(2):143-56
pubmed: 11516708
Neuroimage. 2013 Oct 15;80:105-24
pubmed: 23668970
Neuroimage. 2015 May 15;112:278-287
pubmed: 25770990
Neuroimage. 2013 Oct 15;80:62-79
pubmed: 23684880
J Nucl Med. 1996 Jul;37(7):1242-56
pubmed: 8965206
Psychopharmacology (Berl). 1999 Dec;147(3):314-8
pubmed: 10639691
J Nucl Med. 1995 Jul;36(7):1182-90
pubmed: 7790942
Front Cell Neurosci. 2013 Dec 19;7:260
pubmed: 24391541
Psychol Bull. 1979 Mar;86(2):420-8
pubmed: 18839484
Curr Opin Neurobiol. 2013 Apr;23(2):229-38
pubmed: 23267662
J Neurochem. 2020 Mar;152(6):650-662
pubmed: 31608979
Ann Neurol. 1993 Sep;34(3):324-30
pubmed: 8363349
Mov Disord. 2008 Nov 15;23(15):2129-70
pubmed: 19025984
Cereb Cortex. 2010 May;20(5):1175-86
pubmed: 19710357
Brain. 1991 Oct;114 ( Pt 5):2283-301
pubmed: 1933245
Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):12574-12579
pubmed: 27791099
Rev Esp Med Nucl Imagen Mol. 2013 Nov-Dec;32(6):350-6
pubmed: 23570700
J Neuroophthalmol. 2003 Mar;23(1):34-41
pubmed: 12616088
Neuroimage. 2018 May 1;171:415-436
pubmed: 29278773
Hum Brain Mapp. 2012 Aug;33(8):1763-79
pubmed: 21674693
Ageing Res Rev. 2016 Sep;30:114-21
pubmed: 26802555
J Neurosci. 2000 Mar 15;20(6):2369-82
pubmed: 10704511
Curr Opin Neurobiol. 2009 Dec;19(6):615-20
pubmed: 19896833
Mov Disord. 2016 Nov;31(11):1602-1609
pubmed: 27430479
Medicine (Baltimore). 2016 Aug;95(33):e4048
pubmed: 27537550
Mol Psychiatry. 1999 Mar;4(2):189-91, 104-5
pubmed: 10208452
Trends Neurosci. 2009 Oct;32(10):517-24
pubmed: 19758714
Nat Neurosci. 2005 Nov;8(11):1481-9
pubmed: 16251991
Trends Neurosci. 2007 May;30(5):194-202
pubmed: 17408759
Arch Neurol. 2007 Jan;64(1):20-4
pubmed: 17210805
Biol Psychiatry. 2006 May 15;59(10):908-18
pubmed: 16581032