Immunobiology of Carbohydrates: Implications for Novel Vaccine and Adjuvant Design Against Infectious Diseases.
adaptive immunity
adjuvants
carbohydrate-based adjuvants
carbohydrate-based vaccines
carbohydrates
glycoconjugates
innate immunity
vaccines
Journal
Frontiers in cellular and infection microbiology
ISSN: 2235-2988
Titre abrégé: Front Cell Infect Microbiol
Pays: Switzerland
ID NLM: 101585359
Informations de publication
Date de publication:
2021
2021
Historique:
received:
02
11
2021
accepted:
22
12
2021
entrez:
4
2
2022
pubmed:
5
2
2022
medline:
6
4
2022
Statut:
epublish
Résumé
Carbohydrates are ubiquitous molecules expressed on the surface of nearly all living cells, and their interaction with carbohydrate-binding proteins is critical to many immunobiological processes. Carbohydrates are utilized as antigens in many licensed vaccines against bacterial pathogens. More recently, they have also been considered as adjuvants. Interestingly, unlike other types of vaccines, adjuvants have improved immune response to carbohydrate-based vaccine in humans only in a few cases. Furthermore, despite the discovery of many new adjuvants in the last years, aluminum salts, when needed, remain the only authorized adjuvant for carbohydrate-based vaccines. In this review, we highlight historical and recent advances on the use of glycans either as vaccine antigens or adjuvants, and we review the use of currently available adjuvants to improve the efficacy of carbohydrate-based vaccines. A better understanding of the mechanism of carbohydrate interaction with innate and adaptive immune cells will benefit the design of a new generation of glycan-based vaccines and of immunomodulators to fight both longstanding and emerging diseases.
Identifiants
pubmed: 35118012
doi: 10.3389/fcimb.2021.808005
pmc: PMC8803737
doi:
Substances chimiques
Adjuvants, Immunologic
0
Antigens
0
Carbohydrates
0
Vaccines
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
808005Subventions
Organisme : NIAID NIH HHS
ID : 75N93019C00044
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI121066
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI148273
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI165505
Pays : United States
Informations de copyright
Copyright © 2022 Stefanetti, Borriello, Richichi, Zanoni and Lay.
Déclaration de conflit d'intérêts
FB and IZ are named inventors on invention disclosures and patents involving vaccine adjuvants. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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