Thieno[2,3-
Journal
Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531
Informations de publication
Date de publication:
24 02 2022
24 02 2022
Historique:
pubmed:
5
2
2022
medline:
8
3
2022
entrez:
4
2
2022
Statut:
ppublish
Résumé
Mas-related G protein-coupled receptor X1 (MRGPRX1) is a human sensory neuron-specific receptor and potential target for the treatment of pain. Positive allosteric modulators (PAMs) of MRGPRX1 have the potential to preferentially activate the receptors at the central terminals of primary sensory neurons and minimize itch side effects caused by peripheral activation. Using a high-throughput screening (HTS) hit, a series of thieno[2,3-
Identifiants
pubmed: 35119273
doi: 10.1021/acs.jmedchem.1c01709
pmc: PMC9176367
mid: NIHMS1810113
doi:
Substances chimiques
Pyrimidines
0
Receptors, G-Protein-Coupled
0
mas-related gene-X1 receptor, human
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3218-3228Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR001079
Pays : United States
Organisme : NINDS NIH HHS
ID : T32 NS070201
Pays : United States
Organisme : NINDS NIH HHS
ID : UG3 NS115718
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States
Organisme : NINDS NIH HHS
ID : UH3 NS115718
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS110598
Pays : United States
Organisme : NINDS NIH HHS
ID : R21 NS101954
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS117761
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS070814
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS054791
Pays : United States
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