Pathophysiology and immunogenetics of celiac disease.

Celiac Disease / genetics Genetic Predisposition to Disease Glutens / genetics HLA-DQ Antigens / genetics Humans Immunogenetics
Celiac disease HLA Microbiota Physiopathology Transglutaminase 2

Journal

Clinica chimica acta; international journal of clinical chemistry
ISSN: 1873-3492
Titre abrégé: Clin Chim Acta
Pays: Netherlands
ID NLM: 1302422

Informations de publication

Date de publication:
01 Mar 2022
Historique:
received: 28 11 2021
revised: 20 01 2022
accepted: 28 01 2022
pubmed: 6 2 2022
medline: 4 3 2022
entrez: 5 2 2022
Statut: ppublish

Résumé

Celiac disease (CD) is a chronic inflammatory enteropathy caused by gluten (protein from wheat, rye and, barley) in genetically predisposed individuals carrying the HLA-DQ2/HLA-DQ8 genotype. This pathology has a multifactorial etiology in which HLA genes, the microbiome, gluten and, other environmental factors are involved in the development of the disease. Its pathogenesis involves both innate and adaptive immunity as well as upregulation of IL-15. The objective of this review is to examine the results of current studies on genetic and environmental variables to better understand the pathogenesis of this enteropathy. The complex etiology of celiac disease makes our understanding of the pathogenesis of the disease incomplete, and a better knowledge of the many genetic and environmental components would help us better understand the pathophysiology of celiac disease.

Identifiants

DOI: 10.1016/j.cca.2022.01.022 PMID: 35120899
pubmed: 35120899
pii: S0009-8981(22)00040-7
doi: 10.1016/j.cca.2022.01.022
pii:
doi:

Substances chimiques

HLA-DQ Antigens 0
Glutens 8002-80-0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

74-83

Informations de copyright

Copyright © 2022 Elsevier B.V. All rights reserved.

Auteurs

Sara Aboulaghras (S)

Physiology and Physiopathology Team, Faculty of Sciences, Genomic of Human Pathologies Research, Mohammed V University in Rabat, Morocco; Laboratoire d'Immunologie, Institut National d'Hygiene, Rabat, Morocco.

Daniela Piancatelli (D)

National Research Council (CNR)-Institute of Translational Pharmacology (IFT), L'Aquila, Italy.

Khadija Oumhani (K)

Laboratoire d'Immunologie, Institut National d'Hygiene, Rabat, Morocco.

Abdelaali Balahbib (A)

Laboratory of Zoology and General Biology, Faculty of Sciences, Mohammed V University in Rabat, Rabat, Morocco.

Abdelhakim Bouyahya (A)

Laboratory of Human Pathologies Biology, Department of Biology, Faculty of Sciences, Genomic Center of Human Pathologies Research, Mohammed V University in Rabat, Rabat, Morocco. Electronic address: boyahyaa-90@hotmail.fr.

Khalid Taghzouti (K)

Physiology and Physiopathology Team, Faculty of Sciences, Genomic of Human Pathologies Research, Mohammed V University in Rabat, Morocco.

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Classifications MeSH

questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Syndromes de malabsorption › Maladie coeliaque › Pathophysiology and immunogenetics of celiac disease.
questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › Pathophysiology and immunogenetics of celiac disease.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines végétales › Protéines de stockage des graines › Prolamines › Glutens › Pathophysiology and immunogenetics of celiac disease.
questionsmedicales.fr › Facteurs biologiques › Antigènes › Isoantigènes › Antigènes d'histocompatibilité › Antigènes HLA › Antigènes HLA-D › Antigènes HLA-DQ › Pathophysiology and immunogenetics of celiac disease.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Pathophysiology and immunogenetics of celiac disease.
questionsmedicales.fr › Disciplines des sciences naturelles › Disciplines des sciences biologiques › Biologie › Génétique › Immunogénétique › Pathophysiology and immunogenetics of celiac disease.