Ionic mitigation of CD4
Animals
Aspartic Acid
/ analogs & derivatives
Asthma
/ drug therapy
Cell Cycle Proteins
/ genetics
Cell Proliferation
/ drug effects
Cells, Cultured
Central Nervous System
/ drug effects
Encephalomyelitis, Autoimmune, Experimental
/ drug therapy
Energy Metabolism
/ drug effects
Gene Expression Regulation
Immunomodulating Agents
/ pharmacology
Lung
/ drug effects
Lymphocyte Activation
/ drug effects
Mice, Inbred C57BL
Mice, Transgenic
Pneumonia
/ drug therapy
Pyroglyphidae
/ immunology
Signal Transduction
Th1 Cells
/ drug effects
Th2 Cells
/ drug effects
Transcription, Genetic
Zinc Compounds
/ pharmacology
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
04 02 2022
04 02 2022
Historique:
received:
08
10
2021
accepted:
24
12
2021
entrez:
5
2
2022
pubmed:
6
2
2022
medline:
11
3
2022
Statut:
epublish
Résumé
T helper (Th) cells provide immunity to pathogens but also contribute to detrimental immune responses during allergy and autoimmunity. Th2 cells mediate asthmatic airway inflammation and Th1 cells are involved in the pathogenesis of multiple sclerosis. T cell activation involves complex transcriptional networks and metabolic reprogramming, which enable proliferation and differentiation into Th1 and Th2 cells. The essential trace element zinc has reported immunomodulatory capacity and high zinc concentrations interfere with T cell function. However, how high doses of zinc affect T cell gene networks and metabolism remained so far elusive. Herein, we demonstrate by means of transcriptomic analysis that zinc aspartate (UNIZINK), a registered pharmaceutical infusion solution with high bioavailability, negatively regulates gene networks controlling DNA replication and the energy metabolism of murine CD3/CD28-activated CD4
Identifiants
pubmed: 35121767
doi: 10.1038/s41598-022-04827-6
pii: 10.1038/s41598-022-04827-6
pmc: PMC8816938
doi:
Substances chimiques
Cell Cycle Proteins
0
Immunomodulating Agents
0
Zinc Compounds
0
Aspartic Acid
30KYC7MIAI
zinc aspartate
4OC7QTI23H
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1943Informations de copyright
© 2022. The Author(s).
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