Importance of TP53 codon 72 and intron 3 duplication 16 bp polymorphisms and their haplotypes in susceptibility to sarcopenia in Iranian older adults.
Body composition
Lipid profile
Polymorphism
Sarcopenia
p53
Journal
BMC geriatrics
ISSN: 1471-2318
Titre abrégé: BMC Geriatr
Pays: England
ID NLM: 100968548
Informations de publication
Date de publication:
05 02 2022
05 02 2022
Historique:
received:
18
05
2021
accepted:
13
01
2022
entrez:
6
2
2022
pubmed:
7
2
2022
medline:
19
3
2022
Statut:
epublish
Résumé
Sarcopenia is described as age-related progressive skeletal muscle failure that results in marked reduction in the patient's independence and life quality. In this study, we explored the association of TP53 exon 4 Arg72pro (rs1042522) and Intron 3 16-bp Del/Ins (rs17878362) polymorphisms and their haplotypes with sarcopenia, anthropometric, body composition and biochemical parameters. A total of 254 older individuals (65 sarcopenic and 189 healthy) were recruited in this research and genotyped by PCR-RFLP. Linear regression was applied to find the correlation between TP53 polymorphism, and biochemical and anthropometric parameters. The correlation between TP53 polymorphism and haplotypes and the risk of sarcopenia was investigated by logistic regression. Arg/Pro genotype carriers was at a lower (OR We suggested that the Arg/Pro genotype of the codon 72 polymorphism in exon 4 of TP53, and Arginine-Insertion and Proline-Insertion haplotypes might decrease the risk of sarcopenia in Iranian older adults.
Sections du résumé
BACKGROUND
Sarcopenia is described as age-related progressive skeletal muscle failure that results in marked reduction in the patient's independence and life quality. In this study, we explored the association of TP53 exon 4 Arg72pro (rs1042522) and Intron 3 16-bp Del/Ins (rs17878362) polymorphisms and their haplotypes with sarcopenia, anthropometric, body composition and biochemical parameters.
METHODS
A total of 254 older individuals (65 sarcopenic and 189 healthy) were recruited in this research and genotyped by PCR-RFLP. Linear regression was applied to find the correlation between TP53 polymorphism, and biochemical and anthropometric parameters. The correlation between TP53 polymorphism and haplotypes and the risk of sarcopenia was investigated by logistic regression.
RESULTS
Arg/Pro genotype carriers was at a lower (OR
CONCLUSIONS
We suggested that the Arg/Pro genotype of the codon 72 polymorphism in exon 4 of TP53, and Arginine-Insertion and Proline-Insertion haplotypes might decrease the risk of sarcopenia in Iranian older adults.
Identifiants
pubmed: 35123410
doi: 10.1186/s12877-022-02765-6
pii: 10.1186/s12877-022-02765-6
pmc: PMC8818191
doi:
Substances chimiques
Codon
0
TP53 protein, human
0
Tumor Suppressor Protein p53
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
103Informations de copyright
© 2022. The Author(s).
Références
Cell Stem Cell. 2018 Oct 4;23(4):544-556.e4
pubmed: 30244867
J Bone Miner Res. 2014 Jul;29(7):1531-1540
pubmed: 24677265
Cell Rep. 2016 Mar 15;14(10):2413-25
pubmed: 26947067
Age Ageing. 2019 Jan 1;48(1):16-31
pubmed: 30312372
Aging (Albany NY). 2016 Dec 20;8(12):3450-3467
pubmed: 28025407
Cells. 2019 Dec 19;9(1):
pubmed: 31861518
Oncogene. 2004 Mar 11;23(10):1954-6
pubmed: 14647431
Physiol Genomics. 2009 Mar 3;37(1):58-66
pubmed: 19106183
Int J Mol Sci. 2018 Sep 04;19(9):
pubmed: 30181511
BMC Geriatr. 2020 Aug 6;20(1):279
pubmed: 32762638
Braz J Med Biol Res. 2007 Nov;40(11):1465-72
pubmed: 17934643
Biofactors. 2009 Jan-Feb;35(1):28-35
pubmed: 19319843
Carcinogenesis. 1995 Sep;16(9):2233-6
pubmed: 7554081
J Cell Biochem. 2015 Jul;116(7):1171-8
pubmed: 25545054
Exp Gerontol. 2019 Jul 15;122:67-73
pubmed: 31022445
PeerJ. 2018 Sep 5;6:e5239
pubmed: 30202641
BMC Cancer. 2008 Jan 29;8:32
pubmed: 18230179
J Nutr Health Aging. 2019;23(6):525-531
pubmed: 31233073
Hematol Oncol Stem Cell Ther. 2018 Dec;11(4):189-194
pubmed: 29080400
Dis Markers. 2014;2014:743634
pubmed: 25371596
J Am Med Dir Assoc. 2014 Feb;15(2):95-101
pubmed: 24461239
Gene. 2016 Nov 30;593(2):261-4
pubmed: 27436625
J Endocrinol. 2016 Nov;231(2):R61-R75
pubmed: 27613337
Redox Rep. 2018 Dec;23(1):100-117
pubmed: 29298131
Front Aging Neurosci. 2014 Aug 29;6:230
pubmed: 25221510
BMC Musculoskelet Disord. 2021 May 13;22(1):438
pubmed: 33985476
Age Ageing. 2017 Sep 1;46(5):738-746
pubmed: 28633395
Lancet. 2019 Jun 29;393(10191):2636-2646
pubmed: 31171417
Exp Gerontol. 2017 Oct 1;96:100-103
pubmed: 28647519
Mol Cell Oncol. 2016 Apr 15;3(4):e1173769
pubmed: 27652322
Mol Biol Rep. 2012 Jul;39(7):7479-86
pubmed: 22367371
Exp Gerontol. 2018 Oct 1;111:141-153
pubmed: 30030137
Am J Physiol Endocrinol Metab. 2014 Aug 1;307(3):E245-61
pubmed: 24895282
Saudi J Biol Sci. 2019 Nov;26(7):1338-1343
pubmed: 31762593
Cell Death Dis. 2016 Mar 31;7:e2168
pubmed: 27031965
Nat Rev Cancer. 2009 Feb;9(2):95-107
pubmed: 19165225
Genes Dev. 2005 Sep 15;19(18):2122-37
pubmed: 16131611
Sci Rep. 2018 Oct 2;8(1):14710
pubmed: 30279494
BMC Geriatr. 2018 Aug 22;18(1):188
pubmed: 30134867
Exp Gerontol. 2019 Jul 15;122:25-33
pubmed: 31003004
J Cachexia Sarcopenia Muscle. 2019 Jun;10(3):485-500
pubmed: 30993881
Pathobiology. 2012;79(6):323-8
pubmed: 22688387
World J Stem Cells. 2019 Oct 26;11(10):787-802
pubmed: 31692986
J Appl Physiol (1985). 2019 Oct 1;127(4):1075-1084
pubmed: 31465716