A selective and accurate liquid chromatography-tandem mass spectrometry method for the quantitation of the novel 5-HT
5HT(4) receptor partial agonist
Alzheimer’s disease
Human plasma
Incurred sample reproducibility
LC-MS/MS
Pharmacokinetic study
SUVN-D4010
Journal
Journal of pharmaceutical and biomedical analysis
ISSN: 1873-264X
Titre abrégé: J Pharm Biomed Anal
Pays: England
ID NLM: 8309336
Informations de publication
Date de publication:
20 Mar 2022
20 Mar 2022
Historique:
received:
18
11
2021
revised:
31
12
2021
accepted:
23
01
2022
pubmed:
7
2
2022
medline:
11
3
2022
entrez:
6
2
2022
Statut:
ppublish
Résumé
Liquid chromatography and the tandem mass spectrometry method to quantitate SUVN-D4010 (Usmarapride) in human plasma and urine have been developed and fully validated in compliance with regulatory guidelines. The sample preparation technique is simple and rapid consisting of acetonitrile precipitation followed by dilution of supernatant with a compatible solvent. Chromatographic separation was achieved on an X-Bridge C
Identifiants
pubmed: 35124447
pii: S0731-7085(22)00038-3
doi: 10.1016/j.jpba.2022.114617
pii:
doi:
Substances chimiques
Serotonin
333DO1RDJY
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
114617Informations de copyright
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