Dysplastic gangliocytoma of the cerebellum in a cat.
Cowden syndrome
Lhermitte-Duclos disease
cats
congenital cerebellar malformations
feline
neuropathology
phosphatase and tensin homolog
Journal
Veterinary pathology
ISSN: 1544-2217
Titre abrégé: Vet Pathol
Pays: United States
ID NLM: 0312020
Informations de publication
Date de publication:
05 2022
05 2022
Historique:
pubmed:
9
2
2022
medline:
18
5
2022
entrez:
8
2
2022
Statut:
ppublish
Résumé
A 2.5-year-old cat presented with progressive ataxia and lethargy. Magnetic resonance imaging (MRI) showed enlargement of the cerebellum and herniation of cerebellar vermis. Postmortem examination confirmed the MRI findings, and histopathology showed numerous large dysplastic neurons populating and displacing the Purkinje cell layer and extending into the molecular and granular layers of the cerebellum. The lesion was diagnosed as dysplastic gangliocytoma of the cerebellum. In humans, this tumor is often associated with Cowden syndrome, a genetic disorder characterized by multiple hamartomas and an increased risk of developing certain neoplasms, known to be linked to a germline mutation of the phosphatase and tensin homolog (
Identifiants
pubmed: 35130805
doi: 10.1177/03009858221075594
pmc: PMC9109245
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
459-462Références
J Child Neurol. 2017 Mar;32(3):322-326
pubmed: 27932596
J Radiol Case Rep. 2020 Mar 31;14(3):1-6
pubmed: 33082915
Vet Pathol. 2002 May;39(3):372-8
pubmed: 12014501
Turk Patoloji Derg. 2018;34(1):92-99
pubmed: 25371023
Surg Neurol. 2004 May;61(5):447-54; discussion 454
pubmed: 15120218
Clin Neurol Neurosurg. 1995 May;97(2):175-80
pubmed: 7656495
Acta Neuropathol. 2016 Jun;131(6):803-20
pubmed: 27157931
Vet Pathol. 2009 Sep;46(5):860-8
pubmed: 19429983
Pan Afr Med J. 2019 Jun 14;33:118
pubmed: 31489096
Acta Neurol Scand. 2002 Mar;105(3):137-45
pubmed: 11886354
Vet Pathol. 2011 Sep;48(5):1012-5
pubmed: 20952721
World Neurosurg. 2019 Jul;127:319-325
pubmed: 30905649
Exp Neurol. 2010 Nov;226(1):110-9
pubmed: 20713048
Mod Pathol. 2012 May;25(5):699-708
pubmed: 22301702
Int J Gynecol Pathol. 2012 Jan;31(1):48-56
pubmed: 22123723
Acta Neuropathol. 1987;75(2):209-11
pubmed: 3434227