Dose-independent drug release from 3D printed oral medicines for patient-specific dosing to improve therapy safety.
Additive manufacturing
Dose-independent release
Drug dissolution
FDM 3D printing
Personalized medicine
Tablet design
Journal
International journal of pharmaceutics
ISSN: 1873-3476
Titre abrégé: Int J Pharm
Pays: Netherlands
ID NLM: 7804127
Informations de publication
Date de publication:
25 Mar 2022
25 Mar 2022
Historique:
received:
09
11
2021
revised:
01
02
2022
accepted:
02
02
2022
pubmed:
9
2
2022
medline:
15
3
2022
entrez:
8
2
2022
Statut:
ppublish
Résumé
Fused deposition modelling (FDM) 3D printing provides the ability to address individual patients' therapeutic needs without having to change the formulation every time. This is particularly interesting for dosing and release modelling. In this study, a geometry model was developed that can represent variable dosages while keeping the surface area to volume (SA/V) ratio alike, so the drug release profiles remain similar. The model was tested on three different formulations. Two BCS I active pharmaceutical ingredients (API), pramipexole and levodopa, and one BCS II API, praziquantel, were used. Polyvinyl alcohol (PVA, water soluble) and a combination of vinylpyrrolidone-vinyl acetate copolymer (PVP-VA, water soluble) and ethylene-vinyl acetate (EVA, water insoluble) were used as the polymer matrix. The curves were compared using the similarity factor (f
Identifiants
pubmed: 35131358
pii: S0378-5173(22)00109-0
doi: 10.1016/j.ijpharm.2022.121555
pii:
doi:
Substances chimiques
Polymers
0
Tablets
0
Polyvinyl Alcohol
9002-89-5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
121555Informations de copyright
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