Exercise after influenza or COVID-19 vaccination increases serum antibody without an increase in side effects.
Adjuvants, Immunologic
Animals
Antibodies
Antibodies, Viral
BNT162 Vaccine
COVID-19
/ prevention & control
COVID-19 Vaccines
/ adverse effects
Drug-Related Side Effects and Adverse Reactions
Humans
Influenza A Virus, H1N1 Subtype
Influenza Vaccines
Influenza, Human
/ prevention & control
Mice
Vaccination
/ methods
COVID-19
Exercise
Influenza
Vaccine
Journal
Brain, behavior, and immunity
ISSN: 1090-2139
Titre abrégé: Brain Behav Immun
Pays: Netherlands
ID NLM: 8800478
Informations de publication
Date de publication:
05 2022
05 2022
Historique:
received:
26
10
2021
revised:
27
01
2022
accepted:
01
02
2022
pubmed:
9
2
2022
medline:
13
4
2022
entrez:
8
2
2022
Statut:
ppublish
Résumé
Vaccination is an effective public health measure, yet vaccine efficacy varies across different populations. Adjuvants improve vaccine efficacy but often increase reactogenicity. An unconventional behavioral "adjuvant" is physical exercise at the time of vaccination. Here, in separate experiments, we examined the effect of 90-minute light- to moderate-intensity cycle ergometer or outdoor walk/jog aerobic exercise performed once after immunization on serum antibody response to three different vaccines (2009 pandemic influenza H1N1, seasonal influenza, and COVID-19). Exercise took place after influenza vaccination or after the first dose of Pfizer-BioNTech COVID-19 vaccine. A mouse model of influenza A immunization was used to examine the effect of exercise on antibody response and the role of IFNα as a potential mechanism by treating mice with anti-IFNα antibody. The results show that 90 min of exercise consistently increased serum antibody to each vaccine four weeks post-immunization, and IFNα may partially contribute to the exercise-related benefit. Exercise did not increase side effects after the COVID-19 vaccination. These findings suggest that adults who exercise regularly may increase antibody response to influenza or COVID-19 vaccine by performing a single session of light- to moderate-intensity exercise post-immunization.
Identifiants
pubmed: 35131444
pii: S0889-1591(22)00031-9
doi: 10.1016/j.bbi.2022.02.005
pmc: PMC8816799
pii:
doi:
Substances chimiques
Adjuvants, Immunologic
0
Antibodies
0
Antibodies, Viral
0
COVID-19 Vaccines
0
Influenza Vaccines
0
BNT162 Vaccine
N38TVC63NU
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-10Informations de copyright
Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.
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