The Lipid Droplet Knowledge Portal: A resource for systematic analyses of lipid droplet biology.

Animals Cholesterol Esters / metabolism Data Mining Databases as Topic Genome Humans Inflammation / pathology Lipid Droplets / metabolism Lipid Metabolism Liver / metabolism Male Mice, Inbred C57BL Phenotype Phosphorylation RNA Interference
C16orf54 MSRB3 inflammation proteasome protein targeting proximity labeling sterol ester triacylglycerol

Journal

Developmental cell
ISSN: 1878-1551
Titre abrégé: Dev Cell
Pays: United States
ID NLM: 101120028

Informations de publication

Date de publication:
07 02 2022
Historique:
received: 09 06 2021
revised: 16 11 2021
accepted: 31 12 2021
entrez: 8 2 2022
pubmed: 9 2 2022
medline: 4 3 2022
Statut: ppublish

Résumé

Lipid droplets (LDs) are organelles of cellular lipid storage with fundamental roles in energy metabolism and cell membrane homeostasis. There has been an explosion of research into the biology of LDs, in part due to their relevance in diseases of lipid storage, such as atherosclerosis, obesity, type 2 diabetes, and hepatic steatosis. Consequently, there is an increasing need for a resource that combines datasets from systematic analyses of LD biology. Here, we integrate high-confidence, systematically generated human, mouse, and fly data from studies on LDs in the framework of an online platform named the "Lipid Droplet Knowledge Portal" (https://lipiddroplet.org/). This scalable and interactive portal includes comprehensive datasets, across a variety of cell types, for LD biology, including transcriptional profiles of induced lipid storage, organellar proteomics, genome-wide screen phenotypes, and ties to human genetics. This resource is a powerful platform that can be utilized to identify determinants of lipid storage.

Identifiants

DOI: 10.1016/j.devcel.2022.01.003 PMID: 35134345 PMC: PMC9129885
pubmed: 35134345
pii: S1534-5807(22)00003-X
doi: 10.1016/j.devcel.2022.01.003
pmc: PMC9129885
mid: NIHMS1805294
pii:
doi:

Substances chimiques

Cholesterol Esters 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

387-397.e4

Subventions

Organisme : NCATS NIH HHS
ID : TL1 TR001101
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM124348
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007753
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK124913
Pays : United States
Organisme : NHGRI NIH HHS
ID : U24 HG011453
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM112948
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM097194
Pays : United States
Organisme : NIDDK NIH HHS
ID : UM1 DK105554
Pays : United States

Informations de copyright

Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

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Auteurs

Niklas Mejhert (N)

Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA; Department of Medicine (H7), Karolinska Institutet, Huddinge, 141 86 Stockholm, Sweden.

Katlyn R Gabriel (KR)

Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA; Howard Hughes Medical Institute, Boston, MA 02115, USA.

Scott Frendo-Cumbo (S)

Department of Medicine (H7), Karolinska Institutet, Huddinge, 141 86 Stockholm, Sweden.

Natalie Krahmer (N)

Institute for Diabetes and Obesity, Helmholtz Zentrum München, 85764 Neuherberg, Germany; German Center for Diabetes Research, Neuherberg, Germany.

Jiunn Song (J)

Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.

Leena Kuruvilla (L)

Primary Pharmacology Group, Discovery Sciences, Pfizer Inc., Groton, CT 06340, USA.

Chandramohan Chitraju (C)

Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.

Sebastian Boland (S)

Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.

Dong-Keun Jang (DK)

Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.

Marcin von Grotthuss (M)

Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.

Maria C Costanzo (MC)

Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.

Mikael Rydén (M)

Department of Medicine (H7), Karolinska Institutet, Huddinge, 141 86 Stockholm, Sweden.

James A Olzmann (JA)

Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA 94720, USA; Department of Nutritional Sciences and Toxicology, University of California Berkeley, Berkeley, CA 94720, USA; Miller Institute for Basic Research in Science, University of California Berkeley, Berkeley, CA 94720, USA; Chan Zuckerberg Biohub, San Francisco, CA 94158, USA.

Jason Flannick (J)

Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA 02115, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.

Noël P Burtt (NP)

Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.

Robert V Farese (RV)

Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center on the Causes and Prevention of Cardiovascular Disease (CAP-CVD), Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. Electronic address: robert@hsph.harvard.edu.

Tobias C Walther (TC)

Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA; Howard Hughes Medical Institute, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center on the Causes and Prevention of Cardiovascular Disease (CAP-CVD), Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. Electronic address: twalther@hsph.harvard.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › The Lipid Droplet Knowledge Portal: A resource...
questionsmedicales.fr › Lipides › Lipides membranaires › Stérols › Cholestérol › Cholestérol ester › The Lipid Droplet Knowledge Portal: A resource...
questionsmedicales.fr › Sciences de l'information › Mémorisation et recherche des informations › Fouille de données › The Lipid Droplet Knowledge Portal: A resource...
questionsmedicales.fr › Sciences de l'information › Mémorisation et recherche des informations › Bases de données comme sujet › The Lipid Droplet Knowledge Portal: A resource...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › The Lipid Droplet Knowledge Portal: A resource...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The Lipid Droplet Knowledge Portal: A resource...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › The Lipid Droplet Knowledge Portal: A resource...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Gouttelettes lipidiques › The Lipid Droplet Knowledge Portal: A resource...
questionsmedicales.fr › Métabolisme › Métabolisme lipidique › The Lipid Droplet Knowledge Portal: A resource...
questionsmedicales.fr › Système digestif › Foie › The Lipid Droplet Knowledge Portal: A resource...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › The Lipid Droplet Knowledge Portal: A resource...
questionsmedicales.fr › Phénomènes génétiques › Phénotype › The Lipid Droplet Knowledge Portal: A resource...
questionsmedicales.fr › Métabolisme › Phosphorylation › The Lipid Droplet Knowledge Portal: A resource...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Extinction de l'expression des gènes › Interférence par ARN › The Lipid Droplet Knowledge Portal: A resource...