Jason Flannick

Affiliations
  • Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA, USA. flannick@broadinstitute.org.
  • Department of Pediatrics, Harvard Medical School, Boston, MA, 02115, USA. flannick@broadinstitute.org.
  • Programs in Medical and Population Genetics and Metabolism, Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA. flannick@broadinstitute.org.

Publications (29)

The Contribution of Low-Frequency and Rare Coding Variation to Susceptibility to Type 2 Diabetes.

Current diabetes reports
Avec: Jason Flannick

Evaluating human genetic support for hypothesized metabolic disease genes.

Cell metabolism
Avec: Peter Dornbos , Preeti Singh , Dong-Keun Jang , Anubha Mahajan , Sudha B Biddinger , Jerome I Rotter , Mark I McCarthy , Jason Flannick

The Lipid Droplet Knowledge Portal: A resource for systematic analyses of lipid droplet biology.

Developmental cell
Avec: Niklas Mejhert , Katlyn R Gabriel , Scott Frendo-Cumbo , Natalie Krahmer , Jiunn Song , Leena Kuruvilla , Chandramohan Chitraju , Sebastian Boland , Dong-Keun Jang , Marcin von Grotthuss , Maria C Costanzo , Mikael Rydén , James A Olzmann , Jason Flannick , Noël P Burtt , Robert V Farese , Tobias C Walther

Insights from rare variants into the genetic architecture and biology of youth-onset type 2 diabetes.

Research square
Avec: Soo Heon Kwak , Shylaja Srinivasan , Ling Chen , Jennifer Todd , Josep Mercader , Elizabeth Jensen , Jasmin Divers , Amy Mottl , Catherine Pihoker , Rachelle Gandica , Lori Laffel , Elvira Isganaitis , Morey Haymond , Lynne Levitsky , Toni Pollin , Jose Florez , Jason Flannick

A combined polygenic score of 21,293 rare and 22 common variants improves diabetes diagnosis based on hemoglobin A1C levels.

Nature genetics
Avec: Peter Dornbos , Ryan Koesterer , Andrew Ruttenburg , Trang Nguyen , Joanne B Cole , Auteur inconnu , Aaron Leong , James B Meigs , Jose C Florez , Jerome I Rotter , Miriam S Udler , Jason Flannick

Monogenic Diabetes in Youth With Presumed Type 2 Diabetes: Results From the Progress in Diabetes Genetics in Youth (ProDiGY) Collaboration.

Diabetes care
Avec: Jennifer N Todd , Jeffrey W Kleinberger , Haichen Zhang , Shylaja Srinivasan , Sherida E Tollefsen , Lynne L Levitsky , Lorraine E Levitt Katz , Jeanie B Tryggestad , Fida Bacha , Giuseppina Imperatore , Jean M Lawrence , Catherine Pihoker , Jasmin Divers , Jason Flannick , Dana Dabelea , Jose C Florez , Toni I Pollin

Mapping genomic regulation of kidney disease and traits through high-resolution and interpretable eQTLs.

Nature communications
Avec: Seong Kyu Han , Michelle T McNulty , Christopher J Benway , Pei Wen , Anya Greenberg , Ana C Onuchic-Whitford , Auteur inconnu , Dongkeun Jang , Jason Flannick , Noël P Burtt , Parker C Wilson , Benjamin D Humphreys , Xiaoquan Wen , Zhe Han , Dongwon Lee , Matthew G Sampson

Haploinsufficiency of CYP8B1 associates with increased insulin sensitivity in humans.

The Journal of clinical investigation
Avec: Shiqi Zhong , Raphael Chèvre , David Castaño Mayan , Maria Corlianò , Blake J Cochran , Kai Ping Sem , Theo H van Dijk , Jianhe Peng , Liang Juin Tan , Siddesh V Hartimath , Boominathan Ramasamy , Peter Cheng , Albert K Groen , Folkert Kuipers , Julian L Goggi , Chester Drum , Rob M van Dam , Ru San Tan , Kerry-Anne Rye , Michael R Hayden , Ching-Yu Cheng , Shaji Chacko , Jason Flannick , Xueling Sim , Hong Chang Tan , Roshni R Singaraja

Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants.

Nature genetics
Avec: Krishna G Aragam , Tao Jiang , Anuj Goel , Stavroula Kanoni , Brooke N Wolford , Deepak S Atri , Elle M Weeks , Minxian Wang , George Hindy , Wei Zhou , Christopher Grace , Carolina Roselli , Nicholas A Marston , Frederick K Kamanu , Ida Surakka , Loreto Muñoz Venegas , Paul Sherliker , Satoshi Koyama , Kazuyoshi Ishigaki , Bjørn O Åsvold , Michael R Brown , Ben Brumpton , Paul S de Vries , Olga Giannakopoulou , Panagiota Giardoglou , Daniel F Gudbjartsson , Ulrich Güldener , Syed M Ijlal Haider , Anna Helgadottir , Maysson Ibrahim , Adnan Kastrati , Thorsten Kessler , Theodosios Kyriakou , Tomasz Konopka , Ling Li , Lijiang Ma , Thomas Meitinger , Sören Mucha , Matthias Munz , Federico Murgia , Jonas B Nielsen , Markus M Nöthen , Shichao Pang , Tobias Reinberger , Gavin Schnitzler , Damian Smedley , Gudmar Thorleifsson , Moritz von Scheidt , Jacob C Ulirsch , Auteur inconnu , Auteur inconnu , David O Arnar , Noël P Burtt , Maria C Costanzo , Jason Flannick , Kaoru Ito , Dong-Keun Jang , Yoichiro Kamatani , Amit V Khera , Issei Komuro , Iftikhar J Kullo , Luca A Lotta , Christopher P Nelson , Robert Roberts , Gudmundur Thorgeirsson , Unnur Thorsteinsdottir , Thomas R Webb , Aris Baras , Johan L M Björkegren , Eric Boerwinkle , George Dedoussis , Hilma Holm , Kristian Hveem , Olle Melander , Alanna C Morrison , Marju Orho-Melander , Loukianos S Rallidis , Arno Ruusalepp , Marc S Sabatine , Kari Stefansson , Pierre Zalloua , Patrick T Ellinor , Martin Farrall , John Danesh , Christian T Ruff , Hilary K Finucane , Jemma C Hopewell , Robert Clarke , Rajat M Gupta , Jeanette Erdmann , Nilesh J Samani , Heribert Schunkert , Hugh Watkins , Cristen J Willer , Panos Deloukas , Sekar Kathiresan , Adam S Butterworth , Auteur inconnu

The Neurodegenerative Disease Knowledge Portal: Propelling Discovery Through the Sharing of Neurodegenerative Disease Genomic Resources.

medRxiv : the preprint server for health sciences
Avec: Allison A Dilliott , Maria C Costanzo , Noël P Burtt , Sara Bandres-Ciga , Cornelis Blauwendraat , Bradford Casey , Quy Hoang , Hirotaka Iwaki , Dongkeun Jang , Jonggeol Jeffrey Kim , Hampton L Leonard , Kristin S Levine , Mary Makarious , Trang T Nguyen , Guy A Rouleau , Andrew B Singleton , Patrick Smadbeck , J Solle , Dan Vitale , Mike A Nalls , Jason Flannick , Sali M K Farhan

The Musculoskeletal Knowledge Portal: Making Omics Data Useful to the Broader Scientific Community.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Avec: Douglas P Kiel , John P Kemp , Fernando Rivadeneira , Jennifer J Westendorf , David Karasik , Emma L Duncan , Yuuki Imai , Ralph Müller , Jason Flannick , Lynda Bonewald , Noël Burtt

Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls.

Nature
Avec: Jason Flannick , Josep M Mercader , Christian Fuchsberger , Miriam S Udler , Anubha Mahajan , Jennifer Wessel , Tanya M Teslovich , Lizz Caulkins , Ryan Koesterer , Francisco Barajas-Olmos , Thomas W Blackwell , Eric Boerwinkle , Jennifer A Brody , Federico Centeno-Cruz , Ling Chen , Siying Chen , Cecilia Contreras-Cubas , Emilio Córdova , Adolfo Correa , Maria Cortes , Ralph A DeFronzo , Lawrence Dolan , Kimberly L Drews , Amanda Elliott , James S Floyd , Stacey Gabriel , Maria Eugenia Garay-Sevilla , Humberto García-Ortiz , Myron Gross , Sohee Han , Nancy L Heard-Costa , Anne U Jackson , Marit E Jørgensen , Hyun Min Kang , Megan Kelsey , Bong-Jo Kim , Heikki A Koistinen , Johanna Kuusisto , Joseph B Leader , Allan Linneberg , Ching-Ti Liu , Jianjun Liu , Valeriya Lyssenko , Alisa K Manning , Anthony Marcketta , Juan Manuel Malacara-Hernandez , Angélica Martínez-Hernández , Karen Matsuo , Elizabeth Mayer-Davis , Elvia Mendoza-Caamal , Karen L Mohlke , Alanna C Morrison , Anne Ndungu , Maggie C Y Ng , Colm O'Dushlaine , Anthony J Payne , Catherine Pihoker , Auteur inconnu , Wendy S Post , Michael Preuss , Bruce M Psaty , Ramachandran S Vasan , N William Rayner , Alexander P Reiner , Cristina Revilla-Monsalve , Neil R Robertson , Nicola Santoro , Claudia Schurmann , Wing Yee So , Xavier Soberón , Heather M Stringham , Tim M Strom , Claudia H T Tam , Farook Thameem , Brian Tomlinson , Jason M Torres , Russell P Tracy , Rob M van Dam , Marijana Vujkovic , Shuai Wang , Ryan P Welch , Daniel R Witte , Tien-Yin Wong , Gil Atzmon , Nir Barzilai , John Blangero , Lori L Bonnycastle , Donald W Bowden , John C Chambers , Edmund Chan , Ching-Yu Cheng , Yoon Shin Cho , Francis S Collins , Paul S de Vries , Ravindranath Duggirala , Benjamin Glaser , Clicerio Gonzalez , Ma Elena Gonzalez , Leif Groop , Jaspal Singh Kooner , Soo Heon Kwak , Markku Laakso , Donna M Lehman , Peter Nilsson , Timothy D Spector , E Shyong Tai , Tiinamaija Tuomi , Jaakko Tuomilehto , James G Wilson , Carlos A Aguilar-Salinas , Erwin Bottinger , Brian Burke , David J Carey , Juliana C N Chan , Josée Dupuis , Philippe Frossard , Susan R Heckbert , Mi Yeong Hwang , Young Jin Kim , H Lester Kirchner , Jong-Young Lee , Juyoung Lee , Ruth J F Loos , Ronald C W Ma , Andrew D Morris , Christopher J O'Donnell , Colin N A Palmer , James Pankow , Kyong Soo Park , Asif Rasheed , Danish Saleheen , Xueling Sim , Kerrin S Small , Yik Ying Teo , Christopher Haiman , Craig L Hanis , Brian E Henderson , Lorena Orozco , Teresa Tusié-Luna , Frederick E Dewey , Aris Baras , Christian Gieger , Thomas Meitinger , Konstantin Strauch , Leslie Lange , Niels Grarup , Torben Hansen , Oluf Pedersen , Philip Zeitler , Dana Dabelea , Goncalo Abecasis , Graeme I Bell , Nancy J Cox , Mark Seielstad , Rob Sladek , James B Meigs , Steve S Rich , Jerome I Rotter , Auteur inconnu , Auteur inconnu , Auteur inconnu , Auteur inconnu , Auteur inconnu , Auteur inconnu , Auteur inconnu , Auteur inconnu , Auteur inconnu , David Altshuler , Noël P Burtt , Laura J Scott , Andrew P Morris , Jose C Florez , Mark I McCarthy , Michael Boehnke

Loss of ZnT8 function protects against diabetes by enhanced insulin secretion.

Nature genetics
Avec: Om Prakash Dwivedi , Mikko Lehtovirta , Benoit Hastoy , Vikash Chandra , Nicole A J Krentz , Sandra Kleiner , Deepak Jain , Ann-Marie Richard , Fernando Abaitua , Nicola L Beer , Antje Grotz , Rashmi B Prasad , Ola Hansson , Emma Ahlqvist , Ulrika Krus , Isabella Artner , Anu Suoranta , Daniel Gomez , Aris Baras , Benoite Champon , Anthony J Payne , Daniela Moralli , Soren K Thomsen , Philipp Kramer , Ioannis Spiliotis , Reshma Ramracheya , Pauline Chabosseau , Andria Theodoulou , Rebecca Cheung , Martijn van de Bunt , Jason Flannick , Maddalena Trombetta , Enzo Bonora , Claes B Wolheim , Leena Sarelin , Riccardo C Bonadonna , Patrik Rorsman , Benjamin Davies , Julia Brosnan , Mark I McCarthy , Timo Otonkoski , Jens O Lagerstedt , Guy A Rutter , Jesper Gromada , Anna L Gloyn , Tiinamaija Tuomi , Leif Groop

Ancestry-specific high-risk gene variant profiling unmasks diabetes-associated genes.

Human molecular genetics
Avec: Jianhua Zhang , Weiping Chen , Guanjie Chen , Jason Flannick , Emma Fikse , Glenda Smerin , Katherine Degner , Yanqin Yang , Catherine Xu , Auteur inconnu , Yulong Li , John A Hanover , William F Simonds

FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity.

Cell metabolism
Avec: Nicolas Wieder , Juliana Coraor Fried , Choah Kim , Eriene-Heidi Sidhom , Matthew R Brown , Jamie L Marshall , Carlos Arevalo , Moran Dvela-Levitt , Maria Kost-Alimova , Jonas Sieber , Katlyn R Gabriel , Julian Pacheco , Clary Clish , Hamdah Shafqat Abbasi , Shantanu Singh , Justine C Rutter , Martine Therrien , Haejin Yoon , Zon Weng Lai , Aaron Baublis , Renuka Subramanian , Ranjan Devkota , Jonnell Small , Vedagopuram Sreekanth , Myeonghoon Han , Donghyun Lim , Anne E Carpenter , Jason Flannick , Hilary Finucane , Marcia C Haigis , Melina Claussnitzer , Eric Sheu , Beth Stevens , Bridget K Wagner , Amit Choudhary , Jillian L Shaw , Juan Lorenzo Pablo , Anna Greka

The power of TOPMed imputation for the discovery of Latino-enriched rare variants associated with type 2 diabetes.

Diabetologia
Avec: Alicia Huerta-Chagoya , Philip Schroeder , Ravi Mandla , Aaron J Deutsch , Wanying Zhu , Lauren Petty , Xiaoyan Yi , Joanne B Cole , Miriam S Udler , Peter Dornbos , Bianca Porneala , Daniel DiCorpo , Ching-Ti Liu , Josephine H Li , Lukasz Szczerbiński , Varinderpal Kaur , Joohyun Kim , Yingchang Lu , Alicia Martin , Decio L Eizirik , Piero Marchetti , Lorella Marselli , Ling Chen , Shylaja Srinivasan , Jennifer Todd , Jason Flannick , Rose Gubitosi-Klug , Lynne Levitsky , Rachana Shah , Megan Kelsey , Brian Burke , Dana M Dabelea , Jasmin Divers , Santica Marcovina , Lauren Stalbow , Ruth J F Loos , Burcu F Darst , Charles Kooperberg , Laura M Raffield , Christopher Haiman , Quan Sun , Joseph B McCormick , Susan P Fisher-Hoch , Maria L Ordoñez , James Meigs , Leslie J Baier , Clicerio González-Villalpando , Maria Elena González-Villalpando , Lorena Orozco , Lourdes García-García , Andrés Moreno-Estrada , Auteur inconnu , Carlos A Aguilar-Salinas , Teresa Tusié , Josée Dupuis , Maggie C Y Ng , Alisa Manning , Heather M Highland , Miriam Cnop , Robert Hanson , Jennifer Below , Jose C Florez , Aaron Leong , Josep M Mercader

The First Genome-Wide Association Study for Type 2 Diabetes in Youth: The Progress in Diabetes Genetics in Youth (ProDiGY) Consortium.

Diabetes
Avec: Shylaja Srinivasan , Ling Chen , Jennifer Todd , Jasmin Divers , Samuel Gidding , Steven Chernausek , Rose A Gubitosi-Klug , Megan M Kelsey , Rachana Shah , Mary Helen Black , Lynne E Wagenknecht , Alisa Manning , Jason Flannick , Giuseppina Imperatore , Josep M Mercader , Dana Dabelea , Jose C Florez , Auteur inconnu

Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes.

Nature communications
Avec: Julia K Goodrich , Moriel Singer-Berk , Rachel Son , Abigail Sveden , Jordan Wood , Eleina England , Joanne B Cole , Ben Weisburd , Nick Watts , Lizz Caulkins , Peter Dornbos , Ryan Koesterer , Zachary Zappala , Haichen Zhang , Kristin A Maloney , Andy Dahl , Carlos A Aguilar-Salinas , Gil Atzmon , Francisco Barajas-Olmos , Nir Barzilai , John Blangero , Eric Boerwinkle , Lori L Bonnycastle , Erwin Bottinger , Donald W Bowden , Federico Centeno-Cruz , John C Chambers , Nathalie Chami , Edmund Chan , Juliana Chan , Ching-Yu Cheng , Yoon Shin Cho , Cecilia Contreras-Cubas , Emilio Córdova , Adolfo Correa , Ralph A DeFronzo , Ravindranath Duggirala , Josée Dupuis , Ma Eugenia Garay-Sevilla , Humberto García-Ortiz , Christian Gieger , Benjamin Glaser , Clicerio González-Villalpando , Ma Elena Gonzalez , Niels Grarup , Leif Groop , Myron Gross , Christopher Haiman , Sohee Han , Craig L Hanis , Torben Hansen , Nancy L Heard-Costa , Brian E Henderson , Juan Manuel Malacara Hernandez , Mi Yeong Hwang , Sergio Islas-Andrade , Marit E Jørgensen , Hyun Min Kang , Bong-Jo Kim , Young Jin Kim , Heikki A Koistinen , Jaspal Singh Kooner , Johanna Kuusisto , Soo-Heon Kwak , Markku Laakso , Leslie Lange , Jong-Young Lee , Juyoung Lee , Donna M Lehman , Allan Linneberg , Jianjun Liu , Ruth J F Loos , Valeriya Lyssenko , Ronald C W Ma , Angélica Martínez-Hernández , James B Meigs , Thomas Meitinger , Elvia Mendoza-Caamal , Karen L Mohlke , Andrew D Morris , Alanna C Morrison , Maggie C Y Ng , Peter M Nilsson , Christopher J O'Donnell , Lorena Orozco , Colin N A Palmer , Kyong Soo Park , Wendy S Post , Oluf Pedersen , Michael Preuss , Bruce M Psaty , Alexander P Reiner , Cristina Revilla-Monsalve , Stephen S Rich , Jerome I Rotter , Danish Saleheen , Claudia Schurmann , Xueling Sim , Rob Sladek , Kerrin S Small , Wing Yee So , Timothy D Spector , Konstantin Strauch , Tim M Strom , E Shyong Tai , Claudia H T Tam , Yik Ying Teo , Farook Thameem , Brian Tomlinson , Russell P Tracy , Tiinamaija Tuomi , Jaakko Tuomilehto , Teresa Tusié-Luna , Rob M van Dam , Ramachandran S Vasan , James G Wilson , Daniel R Witte , Tien-Yin Wong , Auteur inconnu , Noël P Burtt , Noah Zaitlen , Mark I McCarthy , Michael Boehnke , Toni I Pollin , Jason Flannick , Josep M Mercader , Anne O'Donnell-Luria , Samantha Baxter , Jose C Florez , Daniel G MacArthur , Miriam S Udler

A glomerular transcriptomic landscape of apolipoprotein L1 in Black patients with focal segmental glomerulosclerosis.

Kidney international
Avec: Michelle T McNulty , Damian Fermin , Felix Eichinger , Dongkeun Jang , Matthias Kretzler , Noël P Burtt , Martin R Pollak , Jason Flannick , Astrid Weins , David J Friedman , Auteur inconnu , Matthew G Sampson

FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity.

bioRxiv : the preprint server for biology
Avec: Nicolas Wieder , Juliana Coraor Fried , Choah Kim , Eriene-Heidi Sidhom , Matthew R Brown , Jamie L Marshall , Carlos Arevalo , Moran Dvela-Levitt , Maria Kost-Alimova , Jonas Sieber , Katlyn R Gabriel , Julian Pacheco , Clary Clish , Hamdah Shafqat Abbasi , Shantanu Singh , Justine Rutter , Martine Therrien , Haejin Yoon , Zon Weng Lai , Aaron Baublis , Renuka Subramanian , Ranjan Devkota , Jonnell Small , Vedagopuram Sreekanth , Myeonghoon Han , Donghyun Lim , Anne E Carpenter , Jason Flannick , Hilary Finucane , Marcia C Haigis , Melina Claussnitzer , Eric Sheu , Beth Stevens , Bridget K Wagner , Amit Choudhary , Jillian L Shaw , Juan Lorenzo Pablo , Anna Greka

The Type 2 Diabetes Knowledge Portal: An open access genetic resource dedicated to type 2 diabetes and related traits.

Cell metabolism
Avec: Maria C Costanzo , Marcin von Grotthuss , Jeffrey Massung , Dongkeun Jang , Lizz Caulkins , Ryan Koesterer , Clint Gilbert , Ryan P Welch , Parul Kudtarkar , Quy Hoang , Andrew P Boughton , Preeti Singh , Ying Sun , Marc Duby , Annie Moriondo , Trang Nguyen , Patrick Smadbeck , Benjamin R Alexander , MacKenzie Brandes , Mary Carmichael , Peter Dornbos , Todd Green , Kenneth C Huellas-Bruskiewicz , Yue Ji , Alexandria Kluge , Aoife C McMahon , Josep M Mercader , Oliver Ruebenacker , Sebanti Sengupta , Dylan Spalding , Daniel Taliun , Auteur inconnu , Philip Smith , Melissa K Thomas , Beena Akolkar , M Julia Brosnan , Andriy Cherkas , Audrey Y Chu , Eric B Fauman , Caroline S Fox , Tania Nayak Kamphaus , Melissa R Miller , Lynette Nguyen , Afshin Parsa , Dermot F Reilly , Hartmut Ruetten , David Wholley , Norann A Zaghloul , Gonçalo R Abecasis , David Altshuler , Thomas M Keane , Mark I McCarthy , Kyle J Gaulton , Jose C Florez , Michael Boehnke , Noël P Burtt , Jason Flannick

Assessing the genetic contribution of cumulative behavioral factors associated with longitudinal type 2 diabetes risk highlights adiposity and the brain-metabolic axis.

medRxiv : the preprint server for health sciences
Avec: Nuno R G Carvalho , Yixuan He , Patrick Smadbeck , Jason Flannick , Josep M Mercader , Miriam Udler , Arjun K Manrai , Jordi Moreno , Chirag J Patel

Discovering metabolic disease gene interactions by correlated effects on cellular morphology.

Molecular metabolism
Avec: Yang Jiao , Umer Ahmed , M F Michelle Sim , Andrea Bejar , Xiaolan Zhang , M Mesbah Uddin Talukder , Robert Rice , Jason Flannick , Anna I Podgornaia , Dermot F Reilly , Jesse M Engreitz , Maria Kost-Alimova , Kate Hartland , Josep-Maria Mercader , Sara Georges , Vilas Wagh , Marija Tadin-Strapps , John G Doench , J Michael Edwardson , Justin J Rochford , Evan D Rosen , Amit R Majithia

Genome-wide Association Study of Lipid Traits in Youth With Type 2 Diabetes.

Journal of the Endocrine Society
Avec: Nicola Santoro , Ling Chen , Jennifer Todd , Jasmin Divers , Amy S Shah , Samuel S Gidding , Brian Burke , Morey Haymond , Leslie Lange , Santica Marcovina , Jason Flannick , Sonia Caprio , Jose C Florez , Shylaja Srinivasan

Genetic architecture and biology of youth-onset type 2 diabetes.

Nature metabolism
Avec: Soo Heon Kwak , Shylaja Srinivasan , Ling Chen , Jennifer Todd , Josep M Mercader , Elizabeth T Jensen , Jasmin Divers , Amy K Mottl , Catherine Pihoker , Rachelle G Gandica , Lori M Laffel , Elvira Isganaitis , Morey W Haymond , Lynne L Levitsky , Toni I Pollin , Jose C Florez , Jason Flannick , Auteur inconnu

Rare loss of function variants in the hepatokine gene INHBE protect from abdominal obesity.

Nature communications
Avec: Aimee M Deaton , Aditi Dubey , Lucas D Ward , Peter Dornbos , Jason Flannick , Auteur inconnu , Elaine Yee , Simina Ticau , Leila Noetzli , Margaret M Parker , Rachel A Hoffing , Carissa Willis , Mollie E Plekan , Aaron M Holleman , Gregory Hinkle , Kevin Fitzgerald , Akshay K Vaishnaw , Paul Nioi

Human gain-of-function variants in HNF1A confer protection from diabetes but independently increase hepatic secretion of atherogenic lipoproteins.

Cell genomics
Avec: Natalie DeForest , Babu Kavitha , Siqi Hu , Roi Isaac , Lynne Krohn , Minxian Wang , Xiaomi Du , Camila De Arruda Saldanha , Jenny Gylys , Edoardo Merli , Ruben Abagyan , Laeya Najmi , Viswanathan Mohan , Auteur inconnu , Auteur inconnu , Jason Flannick , Gina M Peloso , Philip L S M Gordts , Sven Heinz , Aimee M Deaton , Amit V Khera , Jerrold Olefsky , Venkatesan Radha , Amit R Majithia

Genome-wide discovery and integrative genomic characterization of insulin resistance loci using serum triglycerides to HDL-cholesterol ratio as a proxy.

Nature communications
Avec: Natalie DeForest , Yuqi Wang , Zhiyi Zhu , Jacqueline S Dron , Ryan Koesterer , Pradeep Natarajan , Jason Flannick , Tiffany Amariuta , Gina M Peloso , Amit R Majithia

Rare coding variant analysis for human diseases across biobanks and ancestries.

Nature genetics
Avec: Sean J Jurgens , Xin Wang , Seung Hoan Choi , Lu-Chen Weng , Satoshi Koyama , James P Pirruccello , Trang Nguyen , Patrick Smadbeck , Dongkeun Jang , Mark Chaffin , Roddy Walsh , Carolina Roselli , Amanda L Elliott , Leonoor F J M Wijdeveld , Kiran J Biddinger , Shinwan Kany , Joel T Rämö , Pradeep Natarajan , Krishna G Aragam , Jason Flannick , Noël P Burtt , Connie R Bezzina , Steven A Lubitz , Kathryn L Lunetta , Patrick T Ellinor

Réseau de co-auteurs

None None 25 collaborations
Noël P Burtt 9 collaborations
Jose C Florez 9 collaborations
Josep M Mercader 7 collaborations
Peter Dornbos 6 collaborations
Shylaja Srinivasan 6 collaborations
Ling Chen 6 collaborations
Jasmin Divers 6 collaborations
Mark I McCarthy 5 collaborations
Jennifer Todd 5 collaborations
Ryan Koesterer 5 collaborations
Dongkeun Jang 5 collaborations
Jerome I Rotter 4 collaborations
Maria C Costanzo 4 collaborations
Catherine Pihoker 4 collaborations
Miriam S Udler 4 collaborations
Patrick Smadbeck 4 collaborations
Dong-Keun Jang 3 collaborations
Katlyn R Gabriel 3 collaborations
Soo Heon Kwak 3 collaborations
Trang Nguyen 3 collaborations
Joanne B Cole 3 collaborations
James B Meigs 3 collaborations
Dana Dabelea 3 collaborations
Toni I Pollin 3 collaborations
Rob M van Dam 3 collaborations
Ching-Yu Cheng 3 collaborations
Xueling Sim 3 collaborations
Thomas Meitinger 3 collaborations
Aris Baras 3 collaborations
Eric Boerwinkle 3 collaborations
Alanna C Morrison 3 collaborations
Lizz Caulkins 3 collaborations
Maggie C Y Ng 3 collaborations
Leif Groop 3 collaborations
Tiinamaija Tuomi 3 collaborations
Carlos A Aguilar-Salinas 3 collaborations
Brian Burke 3 collaborations
Josée Dupuis 3 collaborations
Ruth J F Loos 3 collaborations
Christopher Haiman 3 collaborations
Lorena Orozco 3 collaborations
Leslie Lange 3 collaborations
Michael Boehnke 3 collaborations
Maria Kost-Alimova 3 collaborations
Amit R Majithia 3 collaborations
Preeti Singh 2 collaborations
Anubha Mahajan 2 collaborations
Marcin von Grotthuss 2 collaborations
Elvira Isganaitis 2 collaborations
Morey Haymond 2 collaborations
Lynne Levitsky 2 collaborations
Aaron Leong 2 collaborations
Haichen Zhang 2 collaborations
Lynne L Levitsky 2 collaborations
Giuseppina Imperatore 2 collaborations
Michelle T McNulty 2 collaborations
Matthew G Sampson 2 collaborations
Krishna G Aragam 2 collaborations
Minxian Wang 2 collaborations
Carolina Roselli 2 collaborations
Satoshi Koyama 2 collaborations
Paul S de Vries 2 collaborations
Amit V Khera 2 collaborations
Patrick T Ellinor 2 collaborations
Quy Hoang 2 collaborations
Francisco Barajas-Olmos 2 collaborations
Federico Centeno-Cruz 2 collaborations
Cecilia Contreras-Cubas 2 collaborations
Emilio Córdova 2 collaborations
Adolfo Correa 2 collaborations
Ralph A DeFronzo 2 collaborations
Humberto García-Ortiz 2 collaborations
Myron Gross 2 collaborations
Sohee Han 2 collaborations
Nancy L Heard-Costa 2 collaborations
Marit E Jørgensen 2 collaborations
Hyun Min Kang 2 collaborations
Megan Kelsey 2 collaborations
Bong-Jo Kim 2 collaborations
Heikki A Koistinen 2 collaborations
Johanna Kuusisto 2 collaborations
Allan Linneberg 2 collaborations
Ching-Ti Liu 2 collaborations
Jianjun Liu 2 collaborations
Valeriya Lyssenko 2 collaborations
Angélica Martínez-Hernández 2 collaborations
Elvia Mendoza-Caamal 2 collaborations
Karen L Mohlke 2 collaborations
Anthony J Payne 2 collaborations
Wendy S Post 2 collaborations
Michael Preuss 2 collaborations
Bruce M Psaty 2 collaborations
Ramachandran S Vasan 2 collaborations
Alexander P Reiner 2 collaborations
Cristina Revilla-Monsalve 2 collaborations
Nicola Santoro 2 collaborations
Claudia Schurmann 2 collaborations
Wing Yee So 2 collaborations
Tim M Strom 2 collaborations
Claudia H T Tam 2 collaborations
Farook Thameem 2 collaborations
Brian Tomlinson 2 collaborations
Russell P Tracy 2 collaborations
Ryan P Welch 2 collaborations
Daniel R Witte 2 collaborations
Tien-Yin Wong 2 collaborations
Gil Atzmon 2 collaborations
Nir Barzilai 2 collaborations
John Blangero 2 collaborations
Lori L Bonnycastle 2 collaborations
Donald W Bowden 2 collaborations
John C Chambers 2 collaborations
Edmund Chan 2 collaborations
Yoon Shin Cho 2 collaborations
Ravindranath Duggirala 2 collaborations
Benjamin Glaser 2 collaborations
Ma Elena Gonzalez 2 collaborations
Jaspal Singh Kooner 2 collaborations
Markku Laakso 2 collaborations
Donna M Lehman 2 collaborations
Timothy D Spector 2 collaborations
E Shyong Tai 2 collaborations
Jaakko Tuomilehto 2 collaborations
James G Wilson 2 collaborations
Erwin Bottinger 2 collaborations
Mi Yeong Hwang 2 collaborations
Young Jin Kim 2 collaborations
Jong-Young Lee 2 collaborations
Juyoung Lee 2 collaborations
Ronald C W Ma 2 collaborations
Andrew D Morris 2 collaborations
Christopher J O'Donnell 2 collaborations
Colin N A Palmer 2 collaborations
Kyong Soo Park 2 collaborations
Danish Saleheen 2 collaborations
Kerrin S Small 2 collaborations
Yik Ying Teo 2 collaborations
Craig L Hanis 2 collaborations
Brian E Henderson 2 collaborations
Teresa Tusié-Luna 2 collaborations
Christian Gieger 2 collaborations
Konstantin Strauch 2 collaborations
Niels Grarup 2 collaborations
Torben Hansen 2 collaborations
Oluf Pedersen 2 collaborations
Rob Sladek 2 collaborations
David Altshuler 2 collaborations
Nicolas Wieder 2 collaborations
Juliana Coraor Fried 2 collaborations
Choah Kim 2 collaborations
Eriene-Heidi Sidhom 2 collaborations
Matthew R Brown 2 collaborations
Jamie L Marshall 2 collaborations
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