Evaluating human genetic support for hypothesized metabolic disease genes.

Human Genetics Humans Metabolic Diseases / genetics

Journal

Cell metabolism
ISSN: 1932-7420
Titre abrégé: Cell Metab
Pays: United States
ID NLM: 101233170

Informations de publication

Date de publication:
03 05 2022
Historique:
pubmed: 15 4 2022
medline: 7 5 2022
entrez: 14 4 2022
Statut: ppublish

Résumé

We investigate the extent to which human genetic data are incorporated into studies that hypothesize novel links between genes and metabolic disease. To lower the barriers to using genetic data, we present an approach to enable researchers to evaluate human genetic support for experimentally determined hypotheses.

Identifiants

DOI: 10.1016/j.cmet.2022.03.011 PMID: 35421386 PMC: PMC9166611
pubmed: 35421386
pii: S1550-4131(22)00125-5
doi: 10.1016/j.cmet.2022.03.011
pmc: PMC9166611
mid: NIHMS1807426
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

661-666

Subventions

Organisme : NIDDK NIH HHS
ID : R01 DK125490
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001881
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK125898
Pays : United States
Organisme : NIDDK NIH HHS
ID : UM1 DK105554
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL151855
Pays : United States

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The views expressed in this article are those of the author(s) and not necessarily those of the NHS, the NIHR, or the Department of Health. M.I.M. has served on advisory panels for Pfizer, NovoNordisk, and Zoe Global; has received honoraria from Merck, Pfizer, Novo Nordisk, and Eli Lilly; and research funding from Abbvie, Astra Zeneca, Boehringer Ingelheim, Eli Lilly, Janssen, Merck, NovoNordisk, Pfizer, Roche, Sanofi Aventis, Servier, and Takeda. As of June 2019, M.I.M. is an employee of Genentech and a holder of Roche stock. A.M. is an employee of Genentech and a holder of Roche stock.

Références

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pubmed: 31118516
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pubmed: 29056338
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pubmed: 29632382
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pubmed: 31981491
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pubmed: 31915397
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pubmed: 18270206
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pubmed: 30239796

Auteurs

Peter Dornbos (P)

Programs in Metabolism and Medical & Population Genetics, Broad Institute, Cambridge, MA, USA; Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.

Preeti Singh (P)

Programs in Metabolism and Medical & Population Genetics, Broad Institute, Cambridge, MA, USA.

Dong-Keun Jang (DK)

Programs in Metabolism and Medical & Population Genetics, Broad Institute, Cambridge, MA, USA.

Anubha Mahajan (A)

Genentech, South San Francisco, CA, USA.

Sudha B Biddinger (SB)

Division of Endocrinology, Boston Children's Hospital, Boston, MA, USA.

Jerome I Rotter (JI)

The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.

Mark I McCarthy (MI)

Genentech, South San Francisco, CA, USA.

Jason Flannick (J)

Programs in Metabolism and Medical & Population Genetics, Broad Institute, Cambridge, MA, USA; Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, USA. Electronic address: flannick@broadinstitute.org.

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Classifications MeSH

questionsmedicales.fr › Disciplines des sciences naturelles › Disciplines des sciences biologiques › Biologie › Génétique › Génétique humaine › Evaluating human genetic support for...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Evaluating human genetic support for...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Evaluating human genetic support for...