Concordance of regional hypoperfusion by pCASL MRI and
Arterial spin labeling (ASL)
Cerebral blood flow (CBF)
Frontotemporal dementia (FTD)
PET/MRI
Radiolabeled water PET ((15)O-water)
sensitivity
Journal
NeuroImage. Clinical
ISSN: 2213-1582
Titre abrégé: Neuroimage Clin
Pays: Netherlands
ID NLM: 101597070
Informations de publication
Date de publication:
2022
2022
Historique:
received:
24
09
2021
revised:
21
01
2022
accepted:
25
01
2022
pubmed:
9
2
2022
medline:
4
3
2022
entrez:
8
2
2022
Statut:
ppublish
Résumé
Clinical diagnosis of frontotemporal dementia (FTD) remains a challenge due to the overlap of symptoms among FTD subtypes and with other psychiatric disorders. Perfusion imaging by arterial spin labeling (ASL) is a promising non-invasive alternative to established PET techniques; however, its sensitivity to imaging parameters can hinder its ability to detect perfusion abnormalities. This study evaluated the similarity of regional hypoperfusion patterns detected by ASL relative to the gold standard for imaging perfusion, PET with radiolabeled water ( Perfusion by single-delay pseudo continuous ASL (SD-pCASL), free-lunch Hadamard encoded pCASL (FL_TE-pCASL), and Region of interest (ROI) based perfusion measured by This study demonstrates the potential of pCASL for assessing regional hypoperfusion related to FTD and supports its use as a cost-effective alternative to PET.
Sections du résumé
BACKGROUND
Clinical diagnosis of frontotemporal dementia (FTD) remains a challenge due to the overlap of symptoms among FTD subtypes and with other psychiatric disorders. Perfusion imaging by arterial spin labeling (ASL) is a promising non-invasive alternative to established PET techniques; however, its sensitivity to imaging parameters can hinder its ability to detect perfusion abnormalities.
PURPOSE
This study evaluated the similarity of regional hypoperfusion patterns detected by ASL relative to the gold standard for imaging perfusion, PET with radiolabeled water (
METHODS AND MATERIALS
Perfusion by single-delay pseudo continuous ASL (SD-pCASL), free-lunch Hadamard encoded pCASL (FL_TE-pCASL), and
RESULTS
Region of interest (ROI) based perfusion measured by
CONCLUSIONS
This study demonstrates the potential of pCASL for assessing regional hypoperfusion related to FTD and supports its use as a cost-effective alternative to PET.
Identifiants
pubmed: 35134705
pii: S2213-1582(22)00015-8
doi: 10.1016/j.nicl.2022.102950
pmc: PMC8829802
pii:
doi:
Substances chimiques
Spin Labels
0
Water
059QF0KO0R
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
102950Subventions
Organisme : CIHR
Pays : Canada
Informations de copyright
Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.
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