Reactions of Arsenoplatin-1 with Protein Targets: A Combined Experimental and Theoretical Study.
Journal
Inorganic chemistry
ISSN: 1520-510X
Titre abrégé: Inorg Chem
Pays: United States
ID NLM: 0366543
Informations de publication
Date de publication:
21 Feb 2022
21 Feb 2022
Historique:
pubmed:
10
2
2022
medline:
3
3
2022
entrez:
9
2
2022
Statut:
ppublish
Résumé
Arsenoplatin-1 (AP-1) is a dual-action anticancer metallodrug with a promising pharmacological profile that features the simultaneous presence of a cisplatin-like center and an arsenite center. We investigated its interactions with proteins through a joint experimental and theoretical approach. The reactivity of AP-1 with a variety of proteins, including carbonic anhydrase (CA), superoxide dismutase (SOD), myoglobin (Mb), glyceraldehyde 3-phosphate dehydrogenase (GAPDH), and human serum albumin (HSA), was analyzed by means of electrospray ionization mass spectrometry (ESI MS) measurements. In accordance with previous observations, ESI MS experiments revealed that the obtained metallodrug-protein adducts originated from the binding of the [(AP-1)-Cl]
Identifiants
pubmed: 35137586
doi: 10.1021/acs.inorgchem.1c03732
pmc: PMC8864615
doi:
Substances chimiques
arsenoplatin-1
0
Cisplatin
Q20Q21Q62J
Arsenic Trioxide
S7V92P67HO
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3240-3248Références
J Chem Theory Comput. 2008 Jul;4(7):1029-31
pubmed: 26636355
Inorganica Chim Acta. 2019 Oct 1;496:
pubmed: 32863421
Cochrane Database Syst Rev. 2013 Aug 16;(8):CD009256
pubmed: 23949842
Inorg Chem. 2014 Apr 21;53(8):3929-31
pubmed: 24694179
Front Chem. 2020 Sep 18;8:812
pubmed: 33195032
Crit Rev Oncol Hematol. 2016 Jun;102:37-46
pubmed: 27105947
Angew Chem Int Ed Engl. 2013 Nov 4;52(45):11785-9
pubmed: 24105908
J Phys Chem A. 2016 Jul 14;120(27):5175-86
pubmed: 27070849
Angew Chem Int Ed Engl. 2013 Oct 4;52(41):10749-52
pubmed: 24038962
Dalton Trans. 2020 May 26;49(20):6776-6789
pubmed: 32374320
Dalton Trans. 2021 Jul 13;50(27):9643-9647
pubmed: 34160519
Cancer Res. 2006 Sep 1;66(17):8847-57
pubmed: 16951202
Angew Chem Int Ed Engl. 2021 Sep 1;60(36):19928-19932
pubmed: 34196088
Dalton Trans. 2015 Sep 7;44(33):14896-905
pubmed: 26226326
Dalton Trans. 2012 Jun 7;41(21):6350-8
pubmed: 22411216
J Inorg Biochem. 2020 Aug;209:111096
pubmed: 32485478
Curr Pharm Des. 2016;22(44):6645-6664
pubmed: 27587202
J Med Chem. 2011 Jan 13;54(1):3-25
pubmed: 21077686
Int J Mol Sci. 2021 Feb 13;22(4):
pubmed: 33668605
Dalton Trans. 2020 Oct 27;49(41):14520-14527
pubmed: 33048079
J Phys Chem A. 2019 Jul 5;123(26):5580-5589
pubmed: 31244115
Oncogene. 2010 Jan 28;29(4):482-91
pubmed: 19881547
J Med Chem. 2009 Mar 12;52(5):1345-57
pubmed: 19220055
J Am Chem Soc. 2019 Apr 24;141(16):6453-6457
pubmed: 30943017
Dalton Trans. 2021 Jan 7;50(1):68-71
pubmed: 33320144
J Inorg Biochem. 2021 Oct;223:111533
pubmed: 34273714
Biophys J. 2000 Apr;78(4):2008-21
pubmed: 10733979
Phys Chem Chem Phys. 2017 Jan 4;19(2):1328-1334
pubmed: 27966695
J Comput Chem. 2003 Apr 30;24(6):669-81
pubmed: 12666158
Molecules. 2021 Sep 06;26(17):
pubmed: 34500854