Advancing Ion Channel Research with Automated Patch Clamp (APC) Electrophysiology Platforms.
Automated patch clamp
Electrophysiology
Ion channels
Manual patch clamp
Journal
Advances in experimental medicine and biology
ISSN: 0065-2598
Titre abrégé: Adv Exp Med Biol
Pays: United States
ID NLM: 0121103
Informations de publication
Date de publication:
2021
2021
Historique:
entrez:
9
2
2022
pubmed:
10
2
2022
medline:
12
2
2022
Statut:
ppublish
Résumé
Since its development on the cusp of the new millennium, automated patch clamp (APC) technology has matured over the last two decades. The increased throughput it afforded promised a new paradigm in ion channel recordings: It offered the potential to overcome the time-consuming, low-throughput bottleneck arising from manual patch clamp (MPC) investigations. This chapter highlights the advances in technology, showing how APC platforms have 'democratised' ion channel recordings, lowering the technical bar whilst substantially raising throughput. It will describe the background of the seminal first-generation and updates on advances in second-generation platforms. Furthermore, the chapter summarises the advances APC has made in ion channel studies, including finding new tool compounds and medicines. New functionality and applications on APC platforms give ion channel researchers flexible tools to study ion channels with high quality and high throughput.
Identifiants
pubmed: 35138608
doi: 10.1007/978-981-16-4254-8_2
doi:
Substances chimiques
Ion Channels
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
21-32Informations de copyright
© 2021. Springer Nature Singapore Pte Ltd.
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