CCR8-targeted specific depletion of clonally expanded Treg cells in tumor tissues evokes potent tumor immunity with long-lasting memory.

Animals Antibodies, Monoclonal Biomarkers, Tumor Cell Differentiation Cell- and Tissue-Based Therapy Forkhead Transcription Factors / genetics Gene Deletion Gene Expression Regulation, Neoplastic Humans Immunologic Memory Mice Neoplasms / metabolism Receptors, CCR8 / genetics T-Lymphocytes, Regulatory

CCR8 TCR repertoire autoimmunity cancer immunotherapy regulatory T cells

Journal

Proceedings of the National Academy of Sciences of the United States of America

ISSN: 1091-6490

Titre abrégé: Proc Natl Acad Sci U S A

Pays: United States

ID NLM: 7505876

Informations de publication

Date de publication:
15 02 2022

Historique:

accepted: 03 01 2022

entrez: 10 2 2022

pubmed: 11 2 2022

medline: 11 3 2022

Statut: ppublish

Résumé

Foxp3-expressing CD25

Identifiants

DOI: 10.1073/pnas.2114282119 PMID: 35140181 PMC: PMC8851483

pubmed: 35140181

pii: 2114282119

doi: 10.1073/pnas.2114282119

pmc: PMC8851483

pii:

doi:

Substances chimiques

Antibodies, Monoclonal 0

Biomarkers, Tumor 0

CCR8 protein, human 0

Ccr8 protein, mouse 0

Forkhead Transcription Factors 0

Foxp3 protein, mouse 0

Receptors, CCR8 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

Informations de copyright

Déclaration de conflit d'intérêts

Competing interest statement: Y.K., W.N., Y. Sonoda, Y.T., K.N., R.M., M. Hagiwara, K.D., T. Kanazawa, A.U., M.Y., T.Y., M. Matsumoto, K. Hojo, S. Shinonome, H.Y., M. Hirata, and M. Haruna are employees of Shionogi & Co., Ltd. H.W. and N.O. are principal investigators of joint research units between Osaka University and Shionogi & Co., Ltd. Y.K., A.K., A. Tanaka, T. Kanazawa, M.Y., T.Y., M. Matsumoto, K. Hojo, S. Shinonome, N.N., H.W., N.O., and S. Sakaguchi are inventors on patents related to targeting CCR8 for cancer immunotherapy.

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