Antiflammatory activity and potential dermatological applications of characterized humic acids from a lignite and a green compost.
Anti-Inflammatory Agents, Non-Steroidal
/ chemistry
Cell Survival
Chromatography, Gel
Coal
/ analysis
Composting
Gas Chromatography-Mass Spectrometry
HaCaT Cells
Humans
Humic Substances
/ analysis
Interleukin-1beta
/ genetics
Interleukin-6
/ genetics
Keratinocytes
/ cytology
Magnetic Resonance Spectroscopy
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
09 02 2022
09 02 2022
Historique:
received:
28
06
2021
accepted:
24
01
2022
entrez:
10
2
2022
pubmed:
11
2
2022
medline:
5
3
2022
Statut:
epublish
Résumé
Long-term exposure to air pollution has been associated with the development of some inflammatory processes related to skin. The goal of modern medicine is the development of new products with antiflammatory action deriving from natural sources to improve environmental and economic sustainability. In this study, two different humic acids (HA) were isolated from from lignite (HA-LIG) and composted artichoke wastes (HA-CYN) and characterized by infrared spectrometry, NMR spectroscopy, thermochemolysis-GC/MS, and high-performance size-exclusion chromatography (HPSEC), while their antiflammatory activity was evaluated on HaCaT cells. Spectroscopic results showing the predominance of apolar aliphatic and aromatic components in HA-LIG, whereas HA-CYN revealed a presence of polysaccharides and polyphenolic lignin residues. The HA application on human keratinocyte pre-treated with Urban Dust revealed a general increase of viability suggesting a protective effect of humic matter due to the content of aromatic, phenolic and lignin components. Conversely, the gene expression of IL-6 and IL-1β cytokines indicated a significant decrease after application of HA-LIG, thus exhibiting a greater antiflammatory power than HA-CYN. The specific combination of HA protective hydrophobic components, viable conformational arrangements, and content of bioactive molecules, suggests an innovative applicability of humic matter in dermatology as skin protectors from environmental irritants and as antiflammatory agents.
Identifiants
pubmed: 35140310
doi: 10.1038/s41598-022-06251-2
pii: 10.1038/s41598-022-06251-2
pmc: PMC8828863
doi:
Substances chimiques
Anti-Inflammatory Agents, Non-Steroidal
0
Coal
0
Humic Substances
0
Interleukin-1beta
0
Interleukin-6
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2152Informations de copyright
© 2022. The Author(s).
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